Výsledky vyhledávání - "Dipak K Sarkar"

Akademický článek

Transgenerational inheritance of fetal alcohol effects on proopiomelanocortin gene expression and methylation, cortisol response to stress, and anxiety-like behaviors in offspring for three generations in rats: Evidence for male germline transmission.

Autor: Omkaram Gangisetty, Shaista Chaudhary, Ajay Palagani, Dipak K Sarkar

Publikováno v: PLoS ONE, Vol 17, Iss 2, p e0263340 (2022)

Previously it has been shown that fetal alcohol exposure increases the stress response partly due to lowering stress regulatory proopiomelanocortin (Pomc) gene expression in the hypothalamus via epigenetic mechanisms for multiple generations in mixed

Externí odkaz: https://doaj.org/article/904770a9b9fa48d3afa9e5d40c81c3a3

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Akademický článek

Ethanol-activated microglial exosomes induce MCP1 signaling mediated death of stress-regulatory proopiomelanocortin neurons in the developing hypothalamus

Autor: Prashant Tarale, Shaista Chaudhary, Sayani Mukherjee, Dipak K. Sarkar

Publikováno v: Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-15 (2024)

Abstract Background Microglia, a type of resident immune cells within the central nervous system, have been implicated in ethanol-activated neuronal death of the stress regulatory proopiomelanocortin (POMC) neuron-producing β-endorphin peptides in t

Externí odkaz: https://doaj.org/article/2bb1f6a8ceb248b391165fa9f3b2a863

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Akademický článek

Altered circadian expression of clock genes and clock-regulatory epigenetic modifiers in saliva of children with fetal alcohol spectrum disorders

Autor: Ujjal Das, Jennifer D. Thomas, Prashant Tarale, Jackie Soja, Sarah Inkelis, Christina Chambers, Dipak K. Sarkar

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)

Abstract Prenatal alcohol-exposed (AE) infants and children often demonstrate disrupted sleep patterns, including more frequent awakenings, reduced total sleep time, and more night-to-night sleep variability. Despite the strong connection between sle

Externí odkaz: https://doaj.org/article/bcf676dbb5cd4f8e9877d2c5307ee53c

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Akademický článek

Fetal Alcohol Exposure Reduces Dopamine Receptor D2 and Increases Pituitary Weight and Prolactin Production via Epigenetic Mechanisms.

Autor: Omkaram Gangisetty, Olivia Wynne, Shaima Jabbar, Cara Nasello, Dipak K Sarkar

Publikováno v: PLoS ONE, Vol 10, Iss 10, p e0140699 (2015)

Recent evidence indicated that alcohol exposure during the fetal period increases the susceptibility to tumor development in mammary and prostate tissues. Whether fetal alcohol exposure increases the susceptibility to prolactin-producing tumor (prola

Externí odkaz: https://doaj.org/article/78ed56e9853f4d19a5af9a3f2827e923

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Akademický článek

Fetal alcohol exposure alters proopiomelanocortin gene expression and hypothalamic-pituitary-adrenal axis function via increasing MeCP2 expression in the hypothalamus.

Autor: Omkaram Gangisetty, Rola Bekdash, George Maglakelidze, Dipak K Sarkar

Publikováno v: PLoS ONE, Vol 9, Iss 11, p e113228 (2014)

Proopiomelanocortin (POMC) is a precursor gene of the neuropeptide β-endorphin in the hypothalamus and is known to regulate various physiological functions including stress response. Several recent reports showed that fetal alcohol exposure programs

Externí odkaz: https://doaj.org/article/948cc3d0fd824219931ec71c9dea9e56

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Akademický článek

Roles of dopamine 2 receptor isoforms and g proteins in ethanol regulated prolactin synthesis and lactotropic cell proliferation.

Autor: Amitabha Sengupta, Dipak K Sarkar

Publikováno v: PLoS ONE, Vol 7, Iss 9, p e45593 (2012)

Alcohol consumption has been shown to increase prolactin (PRL) production and cell proliferation of pituitary lactotropes. It also causes a reduction in the lactotrope's response to dopaminergic agents and a differential expression of dopamine 2 rece

Externí odkaz: https://doaj.org/article/a91ecf91ecd44e2da6f505d907dd08cb

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Akademický článek

Neuroimmune Interactions in Fetal Alcohol Spectrum Disorders: Potential Therapeutic Targets and Intervention Strategies

Autor: Sayani Mukherjee, Prashant Tarale, Dipak K. Sarkar

Publikováno v: Cells, Vol 12, Iss 18, p 2323 (2023)

Fetal alcohol spectrum disorders (FASD) are a set of abnormalities caused by prenatal exposure to ethanol and are characterized by developmental defects in the brain that lead to various overt and non-overt physiological abnormalities. Growing eviden

Externí odkaz: https://doaj.org/article/41e203348a2743aabaa116aa38aa3840

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Supplementary Figure 2 from Beta-Endorphin Cell Therapy for Cancer Prevention

Autor: Dipak K. Sarkar, Pallavi Shrivastava, Shaima Jabbar, Nadka Boyadjieva, Sengottuvelan Murugan, Changqing Zhang

SFigure 2: Representative picture of a back tumor, which developed in some control neuron transplanted animals following intravenous injection of MADB106 cells in female F344 rats.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9687631237bccecede1b88e0ed4cddd5
https://doi.org/10.1158/1940-6207.22525638.v1

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