The Fc-effector function of COVID-19 convalescent plasma contributes to SARS-CoV-2 treatment efficacy in mice

Autor: Ullah, Irfan, Beaudoin-Bussières, Guillaume, Symmes, Kelly, Cloutier, Marc, Ducas, Eric, Tauzin, Alexandra, Laumaea, Annemarie, Grunst, Michael W., Dionne, Katrina, Richard, Jonathan, Bégin, Philippe, Mothes, Walther, Kumar, Priti, Bazin, Renée, Finzi, Andrés, Uchil, Pradeep D.

Publikováno v: In Cell Reports Medicine 17 January 2023 4(1)

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The asymmetric opening of HIV-1 Env by a potent CD4 mimetic enables anti-coreceptor binding site antibodies to mediate ADCC.

Autor: Richard J; Centre de Recherche du CHUM, Montréal, Québec, Canada.; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montréal, Québec, Canada., Grunst MW; Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT, USA., Niu L; Infectious Diseases Division, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA., Díaz-Salinas MA; Department of Microbiology, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA., Tolbert WD; Infectious Diseases Division, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA., Marchitto L; Centre de Recherche du CHUM, Montréal, Québec, Canada.; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montréal, Québec, Canada., Zhou F; Unit on Structural Biology, Division of Basic and Translational Biophysics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD, USA., Bourassa C; Centre de Recherche du CHUM, Montréal, Québec, Canada., Yang D; Department of Chemistry, School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA, USA., Chiu TJ; Department of Chemistry, School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA, USA., Chen HC; Department of Chemistry, School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA, USA., Benlarbi M; Centre de Recherche du CHUM, Montréal, Québec, Canada.; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montréal, Québec, Canada., Gottumukkala S; Infectious Diseases Division, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA., Li W; Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT, USA., Dionne K; Centre de Recherche du CHUM, Montréal, Québec, Canada.; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montréal, Québec, Canada., Bélanger É; Centre de Recherche du CHUM, Montréal, Québec, Canada.; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montréal, Québec, Canada., Chatterjee D; Centre de Recherche du CHUM, Montréal, Québec, Canada.; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montréal, Québec, Canada., Medjahed H; Centre de Recherche du CHUM, Montréal, Québec, Canada., Hendrickson WA; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.; Department of Physiology and Cellular Biophysics, Columbia University, New York, NY, USA., Sodroski J; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Department of Microbiology, Harvard Medical School, Boston, Massachusetts, USA., Lang ZC; Laboratory of Cell Biology, National Cancer Institute, NIH, Bethesda, USA., Morton AJ; Laboratory of Cell Biology, National Cancer Institute, NIH, Bethesda, USA., Huang RK; Laboratory of Cell Biology, National Cancer Institute, NIH, Bethesda, USA., Matthies D; Unit on Structural Biology, Division of Basic and Translational Biophysics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD, USA., Smith AB 3rd; Department of Chemistry, School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA, USA., Mothes W; Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT, USA., Munro JB; Department of Microbiology, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA.; Department of Biochemistry and Molecular Biotechnology, University of Massachusetts Chan Medical School, Worcester, MA, USA., Pazgier M; Infectious Diseases Division, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA., Finzi A; Centre de Recherche du CHUM, Montréal, Québec, Canada.; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montréal, Québec, Canada.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Aug 27. Date of Electronic Publication: 2024 Aug 27.