Zobrazeno 1 - 10 of 114 pro vyhledávání: '"Dionisios Vourloumis"'
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Discovery of Selective Nanomolar Inhibitors for Insulin-Regulated Aminopeptidase Based on α-Hydroxy-β-amino Acid Derivatives of Bestatin
Autor: Dionisios Vourloumis, Ioannis Mavridis, Alexandros Athanasoulis, Ioannis Temponeras, Despoina Koumantou, Petros Giastas, Anastasia Mpakali, Victoria Magrioti, Jacqueline Leib, Peter van Endert, Efstratios Stratikos, Athanasios Papakyriakou
Publikováno v: Journal of medicinal chemistry 65(14), 10098-10117 (2022). doi:10.1021/acs.jmedchem.2c00904
Journal of medicinal chemistry 65(14), 10098 - 10117 (2022). doi:10.1021/acs.jmedchem.2c00904
The oxytocinase subfamily of M1 zinc aminopeptidases comprises emerging drug targets, including the ER-resident aminopeptidases 1 and 2 (ERAP1 and ERAP
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8943044d98ebc7f8b9add9dfb3a96c0b
https://bib-pubdb1.desy.de/record/481559
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4
Heterometallic In(III)–Pd(II) Porous Metal–Organic Framework with Square-Octahedron Topology Displaying High CO2 Uptake and Selectivity toward CH4 and N2
Autor: Dionisios Vourloumis, Ioannis Bratsos, Georgia Charalambopoulou, Nicola Demitri, Theodore Steriotis, Ioannis Spanopoulos, Pantelis N. Trikalitis, Christos Tampaxis
Publikováno v: Inorganic Chemistry. 57:7244-7251
The targeted synthesis of metal–organic frameworks (MOFs) with open metal sites, following reticular chemistry rules, provides a straightforward methodology toward the development of advanced porous materials especially for gas storage/separation a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fc4d99992a1908d75885857503bb6b44
https://doi.org/10.1021/acs.inorgchem.8b00910
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5
Crystal Structures of ERAP2 Complexed with Inhibitors Reveal Pharmacophore Requirements for Optimizing Inhibitor Potency
Autor: Sofia Tsoukalidou, Dionisios Vourloumis, Petros Giastas, Anastasia Mpakali, Rebecca Deprez-Poulain, Irene M. Mavridis, Despoina Koumantou, Efstratios Stratikos, Ronan Gealageas, Emmanuel N. Saridakis, Athanasios Papakyriakou
Publikováno v: ACS Medicinal Chemistry Letters. 8:333-337
Endoplasmic reticulum aminopeptidase 2 assists with the generation of antigenic peptides for presentation onto Major Histocompatibility Class I molecules in humans. Recent evidence has suggested that the activity of ERAP2 may contribute to the genera
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67dc680585e58f3fbf45b4765ca2cba0
https://doi.org/10.1021/acsmedchemlett.6b00505
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6
Exploration of zinc-binding groups for the design of inhibitors for the oxytocinase subfamily of M1 aminopeptidases
Autor: Magdalini Kakou, Despoina Koumantou, Marco Fragai, Sofia Tsoukalidou, Vito Calderone, Efstratios Stratikos, Athanasios Papakyriakou, Dionisios Vourloumis, Ioannis Mavridis
Publikováno v: Bioorganicmedicinal chemistry. 27(24)
The oxytocinase subfamily of M1 aminopeptidases consists of three members, ERAP1, ERAP2 and IRAP that play several important biological roles, including key functions in the generation of antigenic peptides that drive human immune responses. They rep
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9089a6c60724f8bebcaa23502a5be45f
https://pubmed.ncbi.nlm.nih.gov/31711716
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7
Improved Total Synthesis of Tubulysins and Design, Synthesis, and Biological Evaluation of New Tubulysins with Highly Potent Cytotoxicities against Cancer Cells as Potential Payloads for Antibody-Drug Conjugates
Autor: Monette Aujay, Joseph Sandoval, Jun Yin, Dionisios Vourloumis, Stefan Munneke, Rohan D. Erande, Kyriacos C. Nicolaou, Julia Gavrilyuk
Publikováno v: Journal of the American Chemical Society. 140(10)
Improved, streamlined total syntheses of natural tubulysins such as V (Tb45) and U (Tb46) and pretubulysin D (PTb-D43), and their application to the synthesis of designed tubulysin analogues (Tb44, PTb-D42, PTb-D47–PTb-D49, and Tb50–Tb120), are d
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd16e6e856c8a86e1bc5febdab835df2
https://pubmed.ncbi.nlm.nih.gov/29381062
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8
Synthesis and Biopharmaceutical Evaluation of Imatinib Analogues Featuring Unusual Structural Motifs
Autor: Kyriacos C. Nicolaou, Holger Karsunky, Sotirios Totokotsopoulos, Damien Webb, Julia Gavrilyuk, Hanan Fernando, Antonia F. Stepan, Athanasios Papakyriakou, Dionisios Vourloumis
Publikováno v: ChemMedChem. 11:31-37
A convenient synthesis of imatinib, a potent inhibitor of ABL1 kinase and widely prescribed drug for the treatment of a variety of leukemias, was devised and applied to the construction of a series of novel imatinib analogues featuring a number of no
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2a0d75a679e796ef179dcb4c282807b
https://doi.org/10.1002/cmdc.201500510
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9
Total Synthesis and Biological Evaluation of Natural and Designed Tubulysins
Autor: Jun Yin, Rohan D. Erande, Kyriacos C. Nicolaou, Joseph Sandoval, Philipp Klahn, Monette Aujay, Michael Jin, Julia Gavrilyuk, Dionisios Vourloumis, Debashis Mandal
Publikováno v: Journal of the American Chemical Society. 138(5)
A streamlined total synthesis of N(14)-desacetoxytubulysin H (Tb1) based on a C-H activation strategy and a short total synthesis of pretubulysin D (PTb-D43) are described. Applications of the developed synthetic strategies and technologies to the sy
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb6aa7fcb76e80181632ca269a3c91e0
https://pubmed.ncbi.nlm.nih.gov/26829208
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