Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Dionisio Martin-Zanca"'
Autor:
Dionisio Martin-Zanca, Juan Carlos Arevalo, Pilar Pérez, Francis S. Lee, Begoña Anta, Saray López-Benito, Carlos Martín-Rodríguez, Laura Calvo
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
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The development of the nervous system is a temporally and spatially coordinated process that relies on the proper regulation of the genes involved. Neurotrophins and their receptors are directly responsible for the survival and differentiation of sen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::711b14c0c80627e612450a5bf2e7b0dd
https://doi.org/10.1523/jneurosci.4646-14.2015
https://doi.org/10.1523/jneurosci.4646-14.2015
Autor:
Javier Robles‐Valero, Lucía Fernández‐Nevado, Myriam Cuadrado, Luis Francisco Lorenzo‐Martín, Isabel Fernández‐Pisonero, Antonio Abad, Esther Redín, Luis Montuenga, Dionisio Martín‐Zanca, Anna Bigas, Moisés Mallo, Mercedes Dosil, Xosé R. Bustelo
Publikováno v:
Molecular Oncology, Vol 16, Iss 19, Pp 3533-3553 (2022)
Mutations in the VAV1 guanine nucleotide exchange factor 1 have been recently found in peripheral T cell lymphoma and nonsmall‐cell lung cancer (NSCLC). To understand their pathogenic potential, we generated a gene‐edited mouse model that express
Externí odkaz:
https://doaj.org/article/72b8a9a8be78472ba69e39341cfb3818
Autor:
Angeles Almeida, Laura Andres-Martin, Juan P. Bolaños, Maria Delgado-Esteban, Dionisio Martin-Zanca
Publikováno v:
GREDOS. Repositorio Institucional de la Universidad de Salamanca
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El derivado del óxido nítrico, peroxinitrito, activa una cascada de señalización de supervivencia en neuronas. El mecanismo implica la oxidación de la fosfatasa PTEN, que permite incrementar la forma fosforilada (neuroprotectora) de akt. Peroxyn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f9ba80e4d9e5fd81ae5f406c4f54618
https://doi.org/10.1111/j.1471-4159.2007.04450.x
https://doi.org/10.1111/j.1471-4159.2007.04450.x
Autor:
Rocío Benito, Kamila Janusz, María Abáigar, Javier De Las Rivas, María Luisa Martín Hernández, Celia Fontanillo, Jesús M. Hernández-Rivas, Mónica del Rey, Talia Velasco-Hernandez, Daniel Borrego, Ken I. Mills, Dionisio Martin-Zanca, Rebeca Cuello, Francisco J. Campos-Laborie
Publikováno v:
del Rey, M, Benito, R, Fontanillo, C, Campos-Laborie, F J, Janusz, K, Velasco-Hernández, T, Abáigar, M, Hernández, M, Cuello, R, Borrego, D, Martín-Zanca, D, de las Rivas, J, Mills, K I & Hernández-Rivas, J M 2015, ' Deregulation of genes related to iron and mitochondrial metabolism in refractory anemia with ring sideroblasts ', PloS one, vol. 10, no. 5, 0126555 . https://doi.org/10.1371/journal.pone.0126555
PLoS ONE, Vol 10, Iss 5, p e0126555 (2015)
PLoS ONE
Digital.CSIC. Repositorio Institucional del CSIC
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PLoS ONE, Vol 10, Iss 5, p e0126555 (2015)
PLoS ONE
Digital.CSIC. Repositorio Institucional del CSIC
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This is an open access article distributed under the terms of the Creative Commons Attribution License.-- et al.
The presence of SF3B1 gene mutations is a hallmark of refractory anemia with ring sideroblasts (RARS). However, the mechanisms respo
The presence of SF3B1 gene mutations is a hallmark of refractory anemia with ring sideroblasts (RARS). However, the mechanisms respo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7976b3d21196846ebe44cca2b9c1fa09
https://pure.qub.ac.uk/en/publications/deregulation-of-genes-related-to-iron-and-mitochondrial-metabolism-in-refractory-anemia-with-ring-sideroblasts(335e2ada-71a9-49ea-8212-38cec3b24c2d).html
https://pure.qub.ac.uk/en/publications/deregulation-of-genes-related-to-iron-and-mitochondrial-metabolism-in-refractory-anemia-with-ring-sideroblasts(335e2ada-71a9-49ea-8212-38cec3b24c2d).html
Autor:
Lamorna Brown-Swigart, Emmy W. Verschuren, Dionisio Martin-Zanca, Gerard I. Evan, Laura Soucek, Elizabeth R. Lawlor, Maria A. Christophorou
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
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To investigate the functions of the p53 tumor suppressor, we created a new knock-in gene replacement mouse model in which the endogenous Trp53 gene is substituted by one encoding p53ERTAM, a p53 fusion protein whose function is completely dependent o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efd0dbcd19c5fbedbe3520f24a4b1876
https://doi.org/10.1038/ng1572
https://doi.org/10.1038/ng1572
Autor:
Nativitat Rocamora, Sandra Peiró, Mario Encinas, Marta Llovera, Joaquim Egea, Yolanda de Pablo, Joan X. Comella, Dionisio Martin-Zanca
Publikováno v:
Journal of Neurochemistry. 88:422-433
The tyrosine kinase receptors for the neurotrophins (Trk) are a family of transmembrane receptors that regulate the differentiation and survival of different neuronal populations. Neurotrophin binding to Trk leads to the activation of several signall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::674f66cec2df380864bd2ee5982c7130
https://doi.org/10.1046/j.1471-4159.2003.02178.x
https://doi.org/10.1046/j.1471-4159.2003.02178.x
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
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The trkA proto-oncogene encodes a high-affinity NGF receptor that is essential for the survival, differentiation and maintenance of many neural and non-neural cell types. Altered expression of the trkA gene or trkA receptor malfunction have been impl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b87ef5a3fe9053cce604cefff3088b94
https://doi.org/10.1038/sj.onc.1202963
https://doi.org/10.1038/sj.onc.1202963
Publikováno v:
Oncogene. 17:1871-1875
The trkC gene encodes the high-affinity receptor for neurotrophin 3 and plays an important role in the regulation of the survival and differentiation of the mammalian nervous system and in heart development. Chromosomal rearrangements of trkC have be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6c792946cd1731cf3edfcce7576e3f2
https://doi.org/10.1038/sj.onc.1202100
https://doi.org/10.1038/sj.onc.1202100
Publikováno v:
General Pharmacology: The Vascular System. 30:305-314
1. Neurotrophins are molecules that regulate the survival, development and maintenance of specific functions in different populations of nerve cells. 2. In the present work, we studied the localization, at the cellular level, of the different neurotr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9824f4b936bb6d73f5c688fd92e2446e
https://doi.org/10.1016/s0306-3623(97)00361-3
https://doi.org/10.1016/s0306-3623(97)00361-3
Autor:
Isidro Sánchez-García, Carolina Vicente-Dueñas, Talia Velasco-Hernandez, Dionisio Martin-Zanca
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
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Loss of p53 function is a common feature of human cancers and it is required for differentiated tumor cell maintenance; however, it is not known whether sustained inactivation of the p53 pathway is needed for cancer stem cell persistence. Chronic mye
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8792d64d46ad003aea82d777164ec3b
http://hdl.handle.net/10261/67592
http://hdl.handle.net/10261/67592