Zobrazeno 1 - 10 of 107 pro vyhledávání: '"Dionicio Siegel"'
1
Akademický článek
Targeting of REST with rationally-designed small molecule compounds exhibits synergetic therapeutic potential in human glioblastoma cells
Autor: Svetlana B. Panina, Joshua V. Schweer, Qian Zhang, Gaurav Raina, Haley A. Hardtke, Seungjin Kim, Wanjie Yang, Dionicio Siegel, Y. Jessie Zhang
Publikováno v: BMC Biology, Vol 22, Iss 1, Pp 1-22 (2024)
Abstract Background Glioblastoma (GBM) is an aggressive brain cancer associated with poor prognosis, intrinsic heterogeneity, plasticity, and therapy resistance. In some GBMs, cell proliferation is fueled by a transcriptional regulator, repressor ele
Externí odkaz: https://doaj.org/article/b58d579647434e908a08b19c276417dd
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2
Akademický článek
Vinaxanthone inhibits Semaphorin3A induced axonal growth cone collapse in embryonic neurons but fails to block its growth promoting effects on adult neurons
Autor: Evguenia Ivakhnitskaia, Matthew R. Chin, Dionicio Siegel, Victor H. Guaiquil
Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Semaphorin3A is considered a classical repellent molecule for developing neurons and a potent inhibitor of regeneration after nervous system trauma. Vinaxanthone and other Sema3A inhibitors are currently being tested as possible therapeutics
Externí odkaz: https://doaj.org/article/56bd27043b694a9a856581c4699a4529
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3
Akademický článek
Pan-active imidazolopiperazine antimalarials target the Plasmodium falciparum intracellular secretory pathway
Autor: Gregory M. LaMonte, Frances Rocamora, Danushka S. Marapana, Nina F. Gnädig, Sabine Ottilie, Madeline R. Luth, Tilla S. Worgall, Gregory M. Goldgof, Roxanne Mohunlal, T. R. Santha Kumar, Jennifer K. Thompson, Edgar Vigil, Jennifer Yang, Dylan Hutson, Trevor Johnson, Jianbo Huang, Roy M. Williams, Bing Yu Zou, Andrea L. Cheung, Prianka Kumar, Timothy J. Egan, Marcus C. S. Lee, Dionicio Siegel, Alan F. Cowman, David A. Fidock, Elizabeth A. Winzeler
Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Imidazolopiperazines (IZPs) are a class of compounds under clinical development for malaria, but their mechanism of action is unclear. Here, the authors show that IZPs inhibit the parasite’s secretory pathway, affecting protein trafficking and expo
Externí odkaz: https://doaj.org/article/30325ebc8f1440eb95a7ef787cbdca69
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4
Akademický článek
Mechanistic insights gained from cell and molecular analysis of the neuroprotective potential of bioactive natural compounds in an immortalized hippocampal cell line
Autor: Harris A. Weisz, Deborah R. Boone, William S. Coggins, Gabrielle A. Edwards, Hannah E. Willey, Steven G. Widen, Dionicio Siegel, Andrew T. Nelson, Donald S. Prough, Helen L. Hellmich
Publikováno v: PLoS ONE, Vol 17, Iss 6 (2022)
Evaluating novel compounds for neuroprotective effects in animal models of traumatic brain injury (TBI) is a protracted, labor-intensive and costly effort. However, the present lack of effective treatment options for TBI, despite decades of research,
Externí odkaz: https://doaj.org/article/db582d781c84428caddccf89f35d1893
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5
Akademický článek
Distinct biological activities of isomers from several families of branched fatty acid esters of hydroxy fatty acids (FAHFAs)
Autor: Pratik Aryal, Ismail Syed, Jennifer Lee, Rucha Patel, Andrew T. Nelson, Dionicio Siegel, Alan Saghatelian, Barbara B. Kahn
Publikováno v: Journal of Lipid Research, Vol 62, Iss , Pp 100108- (2021)
Branched fatty acid esters of hydroxy fatty acids (FAHFAs) are endogenous lipids with antidiabetic and anti-inflammatory effects. Each FAHFA family consists of esters with different acyl chains and multiple isomers with branch points at different car
Externí odkaz: https://doaj.org/article/1feb5ed25790424086099f64e8f40f56
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6
A class of anti-inflammatory lipids decrease with aging in the central nervous system
Autor: Dan Tan, Srihari Konduri, Meric Erikci Ertunc, Pan Zhang, Justin Wang, Tina Chang, Antonio F. M. Pinto, Andrea Rocha, Cynthia J. Donaldson, Joan M. Vaughan, Raissa G. Ludwig, Elizabeth Willey, Manasi Iyer, Peter C. Gray, Pamela Maher, Nicola J. Allen, J. Bradley Zuchero, Andrew Dillin, Marcelo A. Mori, Steven G. Kohama, Dionicio Siegel, Alan Saghatelian
Publikováno v: Nature Chemical Biology. 19:187-197
Lipids contribute to the structure, development, and function of healthy brains. Dysregulated lipid metabolism is linked to aging and diseased brains. However, our understanding of lipid metabolism in aging brains remains limited. Here we examined th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23ebddb617908cd8b03fe62e66bbdc1c
https://doi.org/10.1038/s41589-022-01165-6
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9
Data from Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate
Autor: John DiGiovanni, Thomas J. Slaga, Dionicio Siegel, Steve Carbajal, Jacob Junco, Okkyung Rho, Jiyoon Cho
In this study, the effects of combining ursolic acid + resveratrol, for possible combined inhibitory effects on skin tumor promotion, were evaluated. Ursolic acid, resveratrol, and the combination of ursolic acid + resveratrol were applied topically
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4f9777ffdc19a62aa39f3847e31dfc52
https://doi.org/10.1158/1940-6207.c.6545180.v1
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