Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Dion Kaiserman"'
Autor:
Dion Kaiserman, Peishen Zhao, Caitlin Lorraine Rowe, Andrea Leong, Nicholas Barlow, Lars Thomas Joeckel, Corinne Hitchen, Sarah Elizabeth Stewart, Morley D Hollenberg, Nigel Bunnett, Andreas Suhrbier, Phillip Ian Bird
Publikováno v:
PLoS ONE, Vol 17, Iss 7, p e0270584 (2022)
Granzyme K (GzmK) is a tryptic member of the granzyme family of chymotrypsin-like serine proteases produced by cells of the immune system. Previous studies have indicated that GzmK activates protease-activated receptor 1 (PAR1) enhancing activation o
Externí odkaz:
https://doaj.org/article/2543c7da6a754a3fa2d4be5da6c98eab
Autor:
Alessandra S. Schanoski, Thuy T. Le, Dion Kaiserman, Caitlin Rowe, Natalie A. Prow, Diego D. Barboza, Cliomar A. Santos, Paolo M. A. Zanotto, Kelly G. Magalhães, Luigi Aurelio, David Muller, Paul Young, Peishen Zhao, Phillip I. Bird, Andreas Suhrbier
Publikováno v:
Frontiers in Immunology, Vol 10 (2020)
Granzyme A (GzmA) is secreted by cytotoxic lymphocytes and has traditionally been viewed as a mediator of cell death. However, a growing body of data suggests the physiological role of GzmA is promotion of inflammation. Here, we show that GzmA is sig
Externí odkaz:
https://doaj.org/article/8880a150ba424bb2bd4a4fe6b50c7fd9
Autor:
Christopher E Andoniou, Vivien R Sutton, Matthew E Wikstrom, Peter Fleming, Kevin Y T Thia, Antony Y Matthews, Dion Kaiserman, Iona S Schuster, Jerome D Coudert, Preethi Eldi, Geeta Chaudhri, Gunasegaran Karupiah, Phillip I Bird, Joseph A Trapani, Mariapia A Degli-Esposti
Publikováno v:
PLoS Pathogens, Vol 10, Iss 12, p e1004526 (2014)
Many immune response genes are highly polymorphic, consistent with the selective pressure imposed by pathogens over evolutionary time, and the need to balance infection control with the risk of auto-immunity. Epidemiological and genomic studies have
Externí odkaz:
https://doaj.org/article/fab4ea6805264d57a3bb478bdec9e2f4
Autor:
Salimeh Ebrahimnezhaddarzi, Catherina H Bird, Cody C Allison, Daniel E Tuipulotu, Xenia Kostoulias, Christophe Macri, Michael D Stutz, Gilu Abraham, Dion Kaiserman, Siew Siew Pang, Si Ming Man, Justine D Mintern, Thomas Naderer, Anton Y Peleg, Marc Pellegrini, James C Whisstock, Phillip I Bird
Publikováno v:
Immunology & Cell Biology. 100:529-546
To control infections phagocytes can directly kill invading microbes. Macrophage-expressed gene 1 (Mpeg1), a pore-forming protein sometimes known as perforin-2, is reported to be essential for bacterial killing following phagocytosis. Mice homozygous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dee1949a71f00de27132bd4e4d0a5002
https://doi.org/10.1111/imcb.12554
https://doi.org/10.1111/imcb.12554
Publikováno v:
Neuroreport. 32(16)
OBJECTIVES: Complete deficiency of the serine protease inhibitor gene, SERPINB6, is responsible for autosomal-recessive, nonsyndromic sensorineural hearing loss in humans. A mouse model of this deafness gene identifies Serpinb6a expression in the neu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca1968207ab3ca6130d52038eb530423
https://pubmed.ncbi.nlm.nih.gov/34554936
https://pubmed.ncbi.nlm.nih.gov/34554936
Publikováno v:
The European journal of neuroscienceREFERENCES. 53(5)
Inactivating mutations of SERPINB6 in humans result in progressive hearing loss starting in early adulthood (DFNB91). We have previously shown that C57BL/6J mice lacking the orthologous gene, Serpinb6a, exhibit progressive hearing loss, which is asso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b3a5e15fb99ac6855cd57d42d27ddd7
https://pubmed.ncbi.nlm.nih.gov/33073422
https://pubmed.ncbi.nlm.nih.gov/33073422
Autor:
Jolanta Saczko, Paulina Kasperkiewicz, Tomasz Janiszewski, Phillip I. Bird, Shuang Li, Marcin Drąg, Niels Bovenschen, Sonia Kołt, Dion Kaiserman, Julita Kulbacka, Guy S. Salvesen, Scott J. Snipas
Publikováno v:
J Biol Chem
Natural killer (NK) cells are key innate immunity effectors that combat viral infections and control several cancer types. For their immune function, human NK cells rely largely on five different cytotoxic proteases, called granzymes (A/B/H/K/M). Gra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30b793b77c72ef46b119cddf7ade7c92
https://europepmc.org/articles/PMC7363135/
https://europepmc.org/articles/PMC7363135/
Autor:
Dion Kaiserman, Luigi Aurelio, Thuy T. Le, Natalie A. Prow, Andreas Suhrbier, Phillip I. Bird, Peishen Zhao, Kelly Grace Magalhães, Diego Damasco Barboza, Alessandra Soares Schanoski, Paul R. Young, Cliomar Alves dos Santos, Paolo Marinho de Andrade Zanotto, David A. Muller, Caitlin L. Rowe
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Frontiers in Immunology, Vol 10 (2020)
Frontiers in Immunology
Universidade de São Paulo (USP)
instacron:USP
Frontiers in Immunology, Vol 10 (2020)
Frontiers in Immunology
Granzyme A (GzmA) is secreted by cytotoxic lymphocytes and has traditionally been viewed as a mediator of cell death. However, a growing body of data suggests the physiological role of GzmA is promotion of inflammation. Here, we show that GzmA is sig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::911bbbdc6d649a2600672a8f37dc7244