Výsledky vyhledávání - "Dion F. Coakley"

Overt hepatic encephalopathy: development of a novel clinician reported outcome tool and electronic caregiver diary

Autor: Bruce F. Scharschmidt, Jasmohan S. Bajaj, Masoud Mokhtarani, R. T. Frederick, K. Coyne, Marzena Jurek, M. Santoro, Dion F. Coakley, Nathan M. Bass, M. K. Margolis, Marwan Ghabril

Publikováno v: Metabolic Brain Disease. 31:1081-1093

Clinical management and clinical trials of patients with overt hepatic encephalopathy (OHE) are compromised by lack of standardized and reproducible tools for its clinical diagnosis or for caregiver (CG) identification of OHE manifestations which mer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7102584a1ef89a356c4c06ff032aa727
https://doi.org/10.1007/s11011-016-9851-9

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Variation in Liver Biochemistries in Patients with Decompensated Cirrhosis: Implications for Assessing Drug-Induced Liver Injury in Clinical Trials

Autor: Jitendra Ganju, Marzena Jurek, Bruce F. Scharschmidt, Masoud Mokhtarani, John M. Vierling, Richard Rowell, Dion F. Coakley

Publikováno v: Pharmaceutical Medicine. 30:95-101

Current approaches to detection of drug-induced liver injury (DILI) are generally based on changes from normal in biochemical liver tests. However, limited information is available regarding the proportion of patients with normal versus abnormal bioc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9edd7e429220c0df7e80cbbe0efadc16
https://doi.org/10.1007/s40290-015-0134-2

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Glutamine and hyperammonemic crises in patients with urea cycle disorders

Publikováno v: Molecular Genetics and Metabolism. 117(1):27-32

Blood ammonia and glutamine levels are used as biomarkers of control in patients with urea cycle disorders (UCDs). This study was undertaken to evaluate glutamine variability and utility as a predictor of hyperammonemic crises (HACs) in UCD patients.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdeeb220675da0ef19ca4a1e39cbc0e7

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Glycerol phenylbutyrate treatment in children with urea cycle disorders: Pooled analysis of short and long-term ammonia control and outcomes

Autor: George A. Diaz, Dion F. Coakley, William J. Rhead, Shawn E. McCandless, Bruce F. Scharschmidt, Wendy E. Smith, Cynthia LeMons, Sandesh C.S. Nagamani, Uta Lichter-Konecki, Masoud Mokhtarani, Susan A. Berry, Brendan Lee

Publikováno v: Molecular Genetics and Metabolism. 112:17-24

Objective To evaluate glycerol phenylbutyrate (GPB) in the treatment of pediatric patients with urea cycle disorders (UCDs). Study design UCD patients (n=26) ages 2months through 17years were treated with GPB and sodium phenylbutyrate (NaPBA) in two

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b10c4a978a12dcd06edc3567e947001b
https://doi.org/10.1016/j.ymgme.2014.02.007

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Population Pharmacokinetic Modeling and Dosing Simulations of Nitrogen‐Scavenging Compounds: Disposition of Glycerol Phenylbutyrate and Sodium Phenylbutyrate in Adult and Pediatric Patients with Urea Cycle Disorders

Autor: B. Lee, Dion F. Coakley, William J. Rhead, George A. Diaz, Klara Dickinson, Uta Lichter-Konecki, Jon P. R. Monteleone, Masoud Mokhtarani, Bruce F. Scharschmidt, Cynthia LeMons, Susan A. Berry

Publikováno v: The Journal of Clinical Pharmacology. 53:699-710

Sodium phenylbutyrate and glycerol phenylbutyrate mediate waste nitrogen excretion in the form of urinary phenylacetylglutamine (PAGN) in patients with urea cycle disorders (UCDs); rare genetic disorders characterized by impaired urea synthesis and h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ec2c0bb125bd84df6147bd1524b629e
https://doi.org/10.1002/jcph.92

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Prospective Multicenter Observational Study of Overt Hepatic Encephalopathy

Autor: Marwan Ghabril, Jasmohan S. Bajaj, Benedict Maliakkal, Dion F. Coakley, M. Santoro, John M. Vierling, Marzena Jurek, V.R. Rustgi, Richard Rowell, Bruce F. Scharschmidt, Don C. Rockey, Masoud Mokhtarani, A. M. Di Bisceglie, Charles S. Landis, A. Enriquez

Publikováno v: Digestive diseases and sciences. 61(6)

Overt hepatic encephalopathy (OHE) is a frequent complication of decompensated cirrhosis. A multicenter prospective observational study was performed to assess the most commonly recorded presenting manifestations of OHE and its associated health-care

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bba9978e1a1ddb3c71ae65765c3e5b27
https://pubmed.ncbi.nlm.nih.gov/26781427

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Urinary phenylacetylglutamine (U-PAGN) concentration as biomarker for adherence in patients with urea cycle disorders (UCD) treated with glycerol phenylbutyrate

Autor: Masoud Mokhtarani, Wendy E. Smith, B. Lee, Bruce F. Scharschmidt, Shawn E. McCandless, Uta Lichter-Konecki, George A. Diaz, J. Bartley, Cary O. Harding, Dion F. Coakley, C. Le Mons, Susan A. Berry

Publikováno v: Molecular Genetics and Metabolism Reports
Molecular Genetics and Metabolism Reports, Vol 5, Iss C, Pp 12-14 (2015)

Urinary phenylacetylglutamine (U-PAGN) concentrations in spot urine samples were analyzed as a dosing biomarker during glycerol phenylbutyrate (GPB) dosing in 68 healthy adults and 66 adult and pediatric patients with urea cycle disorders who partici

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bcf6f9467ef42fcba4890a1cfc39ccc
https://pubmed.ncbi.nlm.nih.gov/28649536

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