Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Dion, Dickman"'
Publikováno v:
STAR Protocols, Vol 5, Iss 1, Pp 102832- (2024)
Summary: GCaMP8f is a sensitive genetically encoded Ca2+ indicator that enables imaging of neuronal activity. Here, we present a protocol to perform Ca2+ imaging of the Drosophila neuromuscular junction using GCaMP8f targeted to pre- or postsynaptic
Externí odkaz:
https://doaj.org/article/b4ab611c182f446e866ea45d6d47abe5
Autor:
Sarah Perry, Yifu Han, Chengjie Qiu, Chun Chien, Pragya Goel, Samantha Nishimura, Manisha Sajnani, Andreas Schmid, Stephan J. Sigrist, Dion Dickman
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Presynaptic homeostatic plasticity adaptively enhances neurotransmitter release following diminished postsynaptic glutamate receptor functionality. Here the authors identify a calcium-independent signaling system where active CaMKII detects a short d
Externí odkaz:
https://doaj.org/article/b16888b1f1694fdcbc097bd374d5a869
Autor:
Yifu Han, Pragya Goel, Jiawen Chen, Sarah Perry, Nancy Tran, Samantha Nishimura, Manisha Sanjani, Chun Chien, Dion Dickman
Publikováno v:
Cell Reports, Vol 42, Iss 7, Pp 112775- (2023)
Summary: Ionotropic glutamate receptors (GluRs) are targets for modulation in Hebbian and homeostatic synaptic plasticity and are remodeled by development, experience, and disease. We have probed the impact of synaptic glutamate levels on the two pos
Externí odkaz:
https://doaj.org/article/22d94072c2f047deab8f1369f16b38ec
Autor:
Yifu Han, Chun Chien, Pragya Goel, Kaikai He, Cristian Pinales, Christopher Buser, Dion Dickman
Publikováno v:
eLife, Vol 11 (2022)
In developing and mature nervous systems, diverse neuronal subtypes innervate common targets to establish, maintain, and modify neural circuit function. A major challenge towards understanding the structural and functional architecture of neural circ
Externí odkaz:
https://doaj.org/article/d7a0e5d35d344c2bab8bcdf533e00549
Autor:
Molly J. Kirk, Brittany R. Benlian, Yifu Han, Arya Gold, Ashvin Ravi, Parker E. Deal, Rosana S. Molina, Mikhail Drobizhev, Dion Dickman, Kristin Scott, Evan W. Miller
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
We combine a chemically-synthesized, voltage-sensitive fluorophore with a genetically encoded, self-labeling enzyme to enable voltage imaging in Drosophila melanogaster. Previously, we showed that a rhodamine voltage reporter (RhoVR) combined with th
Externí odkaz:
https://doaj.org/article/8bb0c427fcf548cfaf73e51d8ca6a5f4
Autor:
Jeffrey W. Santoso, Xiling Li, Divya Gupta, Gio C. Suh, Eric Hendricks, Shaoyu Lin, Sarah Perry, Justin K. Ichida, Dion Dickman, Megan L. McCain
Publikováno v:
APL Bioengineering, Vol 5, Iss 3, Pp 036101-036101-16 (2021)
To develop effective cures for neuromuscular diseases, human-relevant in vitro models of neuromuscular tissues are critically needed to probe disease mechanisms on a cellular and molecular level. However, previous attempts to co-culture motor neurons
Externí odkaz:
https://doaj.org/article/6fd450d7c35443ed846926f94cea84d9
Autor:
Koto Kikuma, Xiling Li, Sarah Perry, Qiuling Li, Pragya Goel, Catherine Chen, Daniel Kim, Nicholas Stavropoulos, Dion Dickman
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
The authors use a forward genetic screen to discover postsynaptic factors required for homeostatic synaptic plasticity at the Drosophila neuromuscular junction. They identify insomniac and the ubiquitin ligase Cul3, genes involved in sleep regulation
Externí odkaz:
https://doaj.org/article/2cb2b85d249444b7998b0a2f3b6dca98
Autor:
Mathias A. Böhme, Anthony W. McCarthy, Andreas T. Grasskamp, Christine B. Beuschel, Pragya Goel, Meida Jusyte, Desiree Laber, Sheng Huang, Ulises Rey, Astrid G. Petzoldt, Martin Lehmann, Fabian Göttfert, Pejmun Haghighi, Stefan W. Hell, David Owald, Dion Dickman, Stephan J. Sigrist, Alexander M. Walter
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Synaptic plasticity ensures functionality during perturbations and enables memory formation. Here, the authors describe homeostatic functional and nano-modular active zone modifications for immediate and long-lasting enhancement of neurotransmitter r
Externí odkaz:
https://doaj.org/article/9733b2fe50774e4e995b69653b092187
Autor:
Pragya Goel, Samantha Nishimura, Karthik Chetlapalli, Xiling Li, Catherine Chen, Dion Dickman
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 14 (2020)
Neurons must establish and stabilize connections made with diverse targets, each with distinct demands and functional characteristics. At Drosophila neuromuscular junctions (NMJs), synaptic strength remains stable in a manipulation that simultaneousl
Externí odkaz:
https://doaj.org/article/3cc414f994d44abbbd3d82c54eff8a7b
Autor:
Pragya Goel, Dion Dickman
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Dual leucine zipper kinase (DLK) activates an intrinsic neuronal response to injury and is also implicated in neurodegeneration. Here, Goel and Dickman characterize how postsynaptic targets adapt to presynaptic DLK signaling through a downregulation
Externí odkaz:
https://doaj.org/article/d8d3fb345bee4339bc6dc9b4dda7bb60