Zobrazeno 1 - 10
of 566
pro vyhledávání: '"Diogo O, Souza"'
Autor:
Guilherme Povala, Bruna Bellaver, Marco Antônio De Bastiani, Wagner S. Brum, Pamela C. L. Ferreira, Andrei Bieger, Tharick A. Pascoal, Andrea L. Benedet, Diogo O. Souza, Ricardo M. Araujo, Bruno Zatt, Pedro Rosa-Neto, Eduardo R. Zimmer, for the Alzheimer’s Disease Neuroimaging Initiative
Publikováno v:
Cell & Bioscience, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Background Changes in soluble amyloid-beta (Aβ) levels in cerebrospinal fluid (CSF) are detectable at early preclinical stages of Alzheimer’s disease (AD). However, whether Aβ levels can predict downstream AD pathological features in cog
Externí odkaz:
https://doaj.org/article/2d34afcff2224b4f905cbb59816241fa
Publikováno v:
Brazilian Journal of Anesthesiology, Vol 71, Iss 6, Pp 660-663 (2021)
Allopurinol is a potent inhibitor of the enzyme xanthine oxidase used in the treatment of hyperuricemia and gout. The aim of this pilot study was to investigate the effects of allopurinol on pain and anxiety in women displaying fibromyalgia refractor
Externí odkaz:
https://doaj.org/article/5c1170ba033b4adfb0e64a7e21bfea87
Autor:
Lavínia Schuler-Faccini, Miguel del Campo, Alfredo García-Alix, Liana O. Ventura, Juliano André Boquett, Vanessa van der Linden, André Pessoa, Hélio van der Linden Júnior, Camila V. Ventura, Mariana Carvalho Leal, Thayne Woycinck Kowalski, Lais Rodrigues Gerzson, Carla Skilhan de Almeida, Lucélia Santi, Walter O. Beys-da-Silva, André Quincozes-Santos, Jorge A. Guimarães, Patricia P. Garcez, Julia do Amaral Gomes, Fernanda Sales Luiz Vianna, André Anjos da Silva, Lucas Rosa Fraga, Maria Teresa Vieira Sanseverino, Alysson R. Muotri, Rafael Lopes da Rosa, Alberto Mantovani Abeche, Clairton Marcolongo-Pereira, Diogo O. Souza
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Five years after the identification of Zika virus as a human teratogen, we reviewed the early clinical manifestations, collectively called congenital Zika syndrome (CZS). Children with CZS have a very poor prognosis with extremely low performance in
Externí odkaz:
https://doaj.org/article/faaf7db36c3d4f5db68c0f9e5cc7f044
Autor:
Wagner S. Brum, Marco Antônio deBastiani, Andrei Bieger, Joseph Therriault, João P. Ferrari‐Souza, Andréa L. Benedet, Paramita Saha‐Chaudhuri, Diogo O. Souza, Nicholas J. Ashton, Henrik Zetterberg, Tharick A. Pascoal, Thomas Karikari, Kaj Blennow, Pedro Rosa‐Neto, Eduardo R. Zimmer, Alzheimer's Disease Neuroimaging Initiative (ADNI)
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 8, Iss 1, Pp n/a-n/a (2022)
Abstract Introduction Alzheimer's disease consensus recommends biomarker dichotomization, a practice with well‐described clinical strengths and methodological limitations. Although neuroimaging studies have explored alternative biomarker interpreta
Externí odkaz:
https://doaj.org/article/e806f30d4a1c443ab30c26f072bb0838
Autor:
Roberto Farina Almeida, Yasmine Nonose, Marcelo Ganzella, Samanta Oliveira Loureiro, Andréia Rocha, Daniele Guilhermano Machado, Bruna Bellaver, Fernanda Urruth Fontella, Douglas T. Leffa, Letícia Ferreira Pettenuzzo, Gianina Teribele Venturin, Samuel Greggio, Jaderson Costa da Costa, Eduardo R. Zimmer, Elaine Elisabetsky, Diogo O. Souza
Publikováno v:
Frontiers in Psychiatry, Vol 12 (2021)
Major depressive disorder (MDD) leads to pervasive changes in the health of afflicted patients. Despite advances in the understanding of MDD and its treatment, profound innovation is needed to develop fast-onset antidepressants with higher effectiven
Externí odkaz:
https://doaj.org/article/bec2801c29414c5cb99cd1dcd4d9f1dc
Autor:
Igor C. Fontana, Débora G. Souza, Diogo O. Souza, Antony Gee, Eduardo R. Zimmer, Salvatore Bongarzone
Publikováno v:
Journal of Medicinal Chemistry. 66:2330-2346
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4da18a7240b7e2abbaecc947daf4b418
https://doi.org/10.1021/acs.jmedchem.2c01572
https://doi.org/10.1021/acs.jmedchem.2c01572
Autor:
Pedro Arend Guazzelli, Giordano Fabricio Cittolin-Santos, Leo Anderson Meira-Martins, Mateus Grings, Yasmine Nonose, Gabriel S. Lazzarotto, Daniela Nogara, Jussemara S. da Silva, Fernanda U. Fontella, Moacir Wajner, Guilhian Leipnitz, Diogo O. Souza, Adriano Martimbianco de Assis
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 12 (2020)
Acute liver failure (ALF) implies a severe and rapid liver dysfunction that leads to impaired liver metabolism and hepatic encephalopathy (HE). Recent studies have suggested that several brain alterations such as astrocytic dysfunction and energy met
Externí odkaz:
https://doaj.org/article/06eaee487fd54ca08618e7adf26aa60e
Autor:
Carlos-Alberto Gonçalves, Letícia Rodrigues, Larissa D. Bobermin, Caroline Zanotto, Adriana Vizuete, André Quincozes-Santos, Diogo O. Souza, Marina C. Leite
Publikováno v:
Frontiers in Neuroscience, Vol 12 (2019)
Based on the concept of the tripartite synapse, we have reviewed the role of glucose-derived compounds in glycolytic pathways in astroglial cells. Glucose provides energy and substrate replenishment for brain activity, such as glutamate and lipid syn
Externí odkaz:
https://doaj.org/article/241e7cb35bf643a4a77e589fdb2d01f9
Autor:
João Pedro Ferrari-Souza, Firoza Z. Lussier, Douglas T. Leffa, Joseph Therriault, Cécile Tissot, Bruna Bellaver, Pâmela C. L. Ferreira, Maura Malpetti, Yi-Ting Wang, Guilherme Povala, Andréa L. Benedet, Nicholas J. Ashton, Mira Chamoun, Stijn Servaes, Gleb Bezgin, Min Su Kang, Jenna Stevenson, Nesrine Rahmouni, Vanessa Pallen, Nina Margherita Poltronetti, John T. O’Brien, James B. Rowe, Ann D. Cohen, Oscar L. Lopez, Dana L. Tudorascu, Thomas K. Karikari, William E. Klunk, Victor L. Villemagne, Jean-Paul Soucy, Serge Gauthier, Diogo O. Souza, Henrik Zetterberg, Kaj Blennow, Eduardo R. Zimmer, Pedro Rosa-Neto, Tharick A. Pascoal
Publikováno v:
Science Advances. 9
Animal studies suggest that the apolipoprotein E ε4 ( APOE ε4) allele is a culprit of early microglial activation in Alzheimer’s disease (AD). Here, we tested the association between APOE ε4 status and microglial activation in living individuals
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95c013b467329c1bbd89b2d9ffbee7a4
https://doi.org/10.1126/sciadv.ade1474
https://doi.org/10.1126/sciadv.ade1474
Autor:
Yanier Núñez Figueredo, Jeney Ramírez-Sanchez, Gisele Hansel, Gilberto L. Pardo-Andreu, Nelson Merino, Guillermo Aparicio, Rene Delgado-Hernández, Laura García-Pupo, Estael Ochoa-Rodríguez, Yamila Verdecia-Reyes, Diogo O. Souza
Publikováno v:
Journal of Pharmacy & Pharmacognosy Research, Vol 4, Iss 4, Pp 153-158 (2016)
Context: Despite the great mortality and morbidity of stroke, treatment options remain limited. We previously showed that JM-20, a novel synthetic molecule, possessed a strong neuroprotective effect in rats subjected to transient middle cerebral arte
Externí odkaz:
https://doaj.org/article/af943445e2ab4e7283e9521f74014c51