The protective effect of inflammatory monocytes during systemic C. albicans infection is dependent on collaboration between C-type lectin-like receptors.

Autor: Aiysha Thompson, Luke C Davies, Chia-Te Liao, Diogo M da Fonseca, James S Griffiths, Robert Andrews, Adam V Jones, Mathew Clement, Gordon D Brown, Ian R Humphreys, Philip R Taylor, Selinda J Orr

Publikováno v: PLoS Pathogens, Vol 15, Iss 6, p e1007850 (2019)

Invasive candidiasis, mainly caused by Candida albicans, is a serious healthcare problem with high mortality rates, particularly in immunocompromised patients. Innate immune cells express pathogen recognition receptors (PRRs) including C-type lectin-

Externí odkaz: https://doaj.org/article/89cb1158055e4646aa716fa2f4f95566

Dependence on Mincle and Dectin-2 Varies With Multiple Candida Species During Systemic Infection

Autor: Aiysha Thompson, Diogo M. da Fonseca, Louise Walker, James S. Griffiths, Philip R. Taylor, Neil A. R. Gow, Selinda J. Orr

Publikováno v: Frontiers in Microbiology, Vol 12 (2021)

More than 95% of invasive Candida infections are caused by four Candida spp. (C. albicans, C. glabrata, C. tropicalis, C. parapsilosis). C-type lectin-like receptors (CLRs), such as Dectin-1, Dectin-2, and Mincle mediate immune responses to C. albica

Externí odkaz: https://doaj.org/article/2d6c3500abba4cc898d8e779fdd825f6

A Human Dectin-2 Deficiency Associated With Invasive Aspergillosis

Autor: Keith Wilson, Pierre J. Rizkallah, Magdalena A. Czubala, Aiysha Thompson, Rosemary Ann Barnes, Mark Gurney, James S Griffiths, P. Lewis White, Selinda J. Orr, Elena Simonazzi, Frank L. van de Veerdonk, Wendy Ingram, Philip R. Taylor, Mariolina Bruno, Diogo M da Fonseca, Julian R. Naglik

Publikováno v: The Journal of Infectious Diseases
The Journal of Infectious Diseases, 224, 1219-1224
Griffiths, J S, White, P L, Czubala, M A, Simonazzi, E, Bruno, M, Thompson, A, Rizkallah, P J, Gurney, M, da Fonseca, D M, Naglik, J R, Ingram, W, Wilson, K, van de Veerdonk, F L, Barnes, R, Taylor, P R & Orr, S J 2021, ' A Human Dectin-2 Deficiency Associated With Invasive Aspergillosis ', The Journal of Infectious Diseases . https://doi.org/10.1093/infdis/jiab145
The Journal of Infectious Diseases, 224, 7, pp. 1219-1224

Immunocompromised patients are highly susceptible to invasive aspergillosis. Herein, we identified a homozygous deletion mutation (507 del C) resulting in a frameshift (N170I) and early stop codon in the fungal binding Dectin-2 receptor, in an immuno

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e4d6476e23d3ab11b4be29a4e080626
https://doi.org/10.1093/infdis/jiab145