Cross-protective effect of a combined L5 plus L3 Leishmania major ribosomal protein based vaccine combined with a Th1 adjuvant in murine cutaneous and visceral leishmaniasis

Autor: Laura Ramirez, Laura Corvo, Mariana C Duarte, Miguel A Chávez-Fumagalli, Diogo G Valadares, Diego M Santos, Camila I de Oliveira, Marta R Escutia, Carlos Alonso, Pedro Bonay, Carlos AP Tavares, Eduardo AF Coelho, Manuel Soto

Publikováno v: Parasites & Vectors, Vol 7, Iss 1, Pp 1-11 (2014)

Abstract Background Two Leishmania major ribosomal proteins L3 (LmL3) and L5 (LmL5) have been described as protective molecules against cutaneous leishmaniasis due to infection with L. major and Leishmania braziliensis in BALB/c mice when immunized w

Externí odkaz: https://doaj.org/article/595fcd636ea74e3ea9864ceb1f46664a

Antigenicity and protective efficacy of a Leishmania amastigote-specific protein, member of the super-oxygenase family, against visceral leishmaniasis.

Autor: Vivian T Martins, Miguel A Chávez-Fumagalli, Lourena E Costa, Adriana M C Canavaci, Adriana M C C Martins, Paula S Lage, Daniela P Lage, Mariana C Duarte, Diogo G Valadares, Rubens D M Magalhães, Tatiana G Ribeiro, Ronaldo A P Nagem, Wanderson D Darocha, Wiliam C B Régis, Manuel Soto, Eduardo A F Coelho, Ana Paula Fernandes, Carlos A P Tavares

Publikováno v: PLoS Neglected Tropical Diseases, Vol 7, Iss 3, p e2148 (2013)

BackgroundThe present study aimed to evaluate a hypothetical Leishmania amastigote-specific protein (LiHyp1), previously identified by an immunoproteomic approach performed in Leishmania infantum, which showed homology to the super-oxygenase gene fam

Externí odkaz: https://doaj.org/article/1ed48caba5074aee8f85afeec8e6a389

An Anti-Inflammatory Role for NLRP10 in Murine Cutaneous Leishmaniasis

Autor: Tyler K. Ulland, Joel W. Graff, Breanna M. Scorza, Mary E. Wilson, Bayan Zhanbolat, Diogo G. Valadares, Yani Chen, Richard E. Davis, Fayyaz S. Sutterwala, Gwendolyn M. Clay

Publikováno v: The Journal of Immunology. 199:2823-2833

The role of the nucleotide-binding domain and leucine-rich repeat containing receptor NLRP10 in disease is incompletely understood. Using three mouse strains lacking the gene encoding NLRP10, only one of which had a coincidental mutation in DOCK8, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e41bfd25abc458b07cda6f273c0e0e82
https://doi.org/10.4049/jimmunol.1500832

Coinfection with Leishmania major and Staphylococcus aureus enhances the pathologic responses to both microbes through a pathway involving IL-17A

Autor: Tiffany Y. Borbón, Gwendolyn M. Clay, Breanna M. Scorza, Suzanne L. Cassel, Diogo G. Valadares, Alexander R. Horswill, Corey P. Parlet, Fellipe Lima Nobre de Queiroz, William M. Nauseef, Alan Sariol, Mary E. Wilson, Yani Chen, Jayden L. Bowen, Bayan Zhanbolat, Fayyaz S. Sutterwala

Publikováno v: PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 13, Iss 5, p e0007247 (2019)

Cutaneous leishmaniasis (CL) is a parasitic disease causing chronic, ulcerating skin lesions. Most humans infected with the causative Leishmania protozoa are asymptomatic. Leishmania spp. are usually introduced by sand flies into the dermis of mammal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4c671dd511375596aee68b1e31c6405
https://pubmed.ncbi.nlm.nih.gov/31107882

Strychnos pseudoquinaand Its Purified Compounds Present an EffectiveIn VitroAntileishmanial Activity

Autor: Lourena E. Costa, Tatiana G. Ribeiro, Miguel Angel Chávez Fumagalli, Mariana C. Duarte, José Dias de Souza Filho, Vívian T. Martins, João Paulo Viana Leite, Paula S. Lage, Eduardo A.F. Coelho, Diogo G. Valadares, Pedro H.R. Andrade, Amanda de Santana Lopes, Daniela P. Lage, Rodrigo Maia de Pádua, Carlos Alberto Pereira Tavares

Publikováno v: LOCUS Repositório Institucional da UFV
Universidade Federal de Viçosa (UFV)
instacron:UFV
Evidence-Based Complementary and Alternative Medicine, Vol 2013 (2013)
Evidence-based Complementary and Alternative Medicine : eCAM

The development of new and cost-effective alternative therapeutic strategies to treat leishmaniasis has become a high priority. In the present study, the antileishmanial activity ofStrychnos pseudoquinaSt. Hil. was investigated and pure compounds tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9dd3310b103ea31cc3afdf27accbac4
https://doi.org/10.1155/2013/304354