Brucella induces an unfolded protein response via TcpB that supports intracellular replication in macrophages.

Autor: Judith A Smith, Mike Khan, Diogo D Magnani, Jerome S Harms, Marina Durward, Girish K Radhakrishnan, Yi-Ping Liu, Gary A Splitter

Publikováno v: PLoS Pathogens, Vol 9, Iss 12, p e1003785 (2013)

Brucella melitensis is a facultative intracellular bacterium that causes brucellosis, the most prevalent zoonosis worldwide. The Brucella intracellular replicative niche in macrophages and dendritic cells thwarts immune surveillance and complicates b

Externí odkaz: https://doaj.org/article/e78fc4889d224b61b74840dbc5883805

The impact of IdeS (imlifidase) on allo-specific, xeno-reactive, and protective antibodies in a sensitized rhesus macaque model.

Autor: DeLaura I; Duke Transplant Center, Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA., Zikos J; MassBiologics of University of Massachusetts Medical School, Boston, Massachusetts, USA., Anwar IJ; Duke Transplant Center, Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA., Yoon J; Duke Transplant Center, Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA., Ladowski J; Duke Transplant Center, Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA., Jackson A; Duke Transplant Center, Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA., Van Rompay K; California National Primate Research Center, University of California, Davis, California, USA., Magnani D; MassBiologics of University of Massachusetts Medical School, Boston, Massachusetts, USA., Knechtle SJ; Duke Transplant Center, Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA., Kwun J; Duke Transplant Center, Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA.

Publikováno v: Xenotransplantation [Xenotransplantation] 2024 Jan-Feb; Vol. 31 (1), pp. e12833. Date of Electronic Publication: 2023 Oct 21.

Postnatal Zika virus infection of nonhuman primate infants born to mothers infected with homologous Brazilian Zika virus.

Autor: Maness NJ; Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, Louisiana, USA. nmaness@tulane.edu.; Tulane National Primate Research Center, Tulane University, Covington, Louisiana, USA. nmaness@tulane.edu., Schouest B; Tulane National Primate Research Center, Tulane University, Covington, Louisiana, USA.; Biomedical Sciences Training Program, Tulane University School of Medicine, New Orleans, Louisiana, USA., Singapuri A; Department of Pathology, Microbiology and Immunology, University of California, Davis, CA, USA., Dennis M; Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA., Gilbert MH; Tulane National Primate Research Center, Tulane University, Covington, Louisiana, USA., Bohm RP; Tulane National Primate Research Center, Tulane University, Covington, Louisiana, USA., Schiro F; Tulane National Primate Research Center, Tulane University, Covington, Louisiana, USA., Aye PP; Tulane National Primate Research Center, Tulane University, Covington, Louisiana, USA., Baker K; Tulane National Primate Research Center, Tulane University, Covington, Louisiana, USA., Van Rompay KKA; Department of Pathology, Microbiology and Immunology, University of California, Davis, CA, USA.; California National Primate Research Center, University of California, Davis, California, USA., Lackner AA; Tulane National Primate Research Center, Tulane University, Covington, Louisiana, USA., Bonaldo MC; Laboratório de Biologia Molecular de Flavivírus, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, RJ, Brazil., Blair RV; Tulane National Primate Research Center, Tulane University, Covington, Louisiana, USA., Permar SR; Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA.; Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, USA., Coffey LL; Department of Pathology, Microbiology and Immunology, University of California, Davis, CA, USA., Panganiban AT; Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, Louisiana, USA.; Tulane National Primate Research Center, Tulane University, Covington, Louisiana, USA., Magnani D; MassBiologics of the University of Massachusetts Medical School, Boston, Massachusetts, USA.

Publikováno v: Scientific reports [Sci Rep] 2019 Sep 05; Vol. 9 (1), pp. 12802. Date of Electronic Publication: 2019 Sep 05.

Active evasion of CTL mediated killing and low quality responding CD8+ T cells contribute to persistence of brucellosis.

Autor: Durward M; Department of Pathology and Laboratory Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, United States of America., Radhakrishnan G, Harms J, Bareiss C, Magnani D, Splitter GA

Publikováno v: PloS one [PLoS One] 2012; Vol. 7 (4), pp. e34925. Date of Electronic Publication: 2012 Apr 25.