Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Diogenes Herreno-saenz"'
Publikováno v:
Polycyclic Aromatic Compounds. 16:151-159
N-(Deoxyguanosin-8-yl)-2-aminopyrene and N-(deoxyadenosin-8-yl)-2-aminopyrene were formed from metabolism of 2-nitropyrene (2-NP) in vitro and in vivo. The effects of dietary restriction (DR) and age on the formation of these DNA adducts were studied
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::320d35b11fe042ceea9868272093a091
https://doi.org/10.1080/10406639908020582
https://doi.org/10.1080/10406639908020582
Autor:
Peter P. Fu, Diogenes Herreno-saenz
Publikováno v:
Journal of Environmental Science and Health, Part C. 17:1-43
(1999). Halogenated‐polycyclic aromatic hydrocarbons: A class of Genotoxic environmental pollutants. Journal of Environmental Science and Health, Part C: Vol. 17, No. 2, pp. 71-109.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5bf27b9c42b1c594573cd47e477227f
https://doi.org/10.1080/10590509909373506
https://doi.org/10.1080/10590509909373506
Autor:
Feng Yun Qui, Diogenes Herreno-Saenz, Linda S. Von Tungeln, Ping Yi, Joellen Lewtas, Peter P. Fu, De-Jin Zhan
Publikováno v:
Polycyclic Aromatic Compounds. 10:187-194
We have characterized the DNA adducts of a series of nitro-polycyclic aromatic hydrocarbons (nitro-PAHs) formed under anaerobic conditions in vitro. Although the DNA adducts of nitro-PAHs formed through enzymatic nitroreduction are generally the C8-d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68b4f572ef41420a9e0ae3889a78ecce
https://doi.org/10.1080/10406639608034696
https://doi.org/10.1080/10406639608034696
Autor:
Linda S. Von Tungeln, Joellen Lewtas, De-Jin Zhan, Peter P. Fu, Yu-Sun Wu, Diogenes Herreno-Saenz, Li-Hsueh Chiu
Publikováno v:
Journal of Chromatography A. 710:149-157
32 P-Postlabeling-HPLC is a highly sensitive analytical method for identification of chemical-modified DNA adducts isolated from samples obtained from experimental animals or humans exposed to carcinogenic chemicals. To determine optimal 32 P-postlab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a546056c04b6845216f1caaf97481e96
https://doi.org/10.1016/0021-9673(95)00290-4
https://doi.org/10.1016/0021-9673(95)00290-4
Publikováno v:
Chemical Research in Toxicology. 8:269-277
1-Nitropyrene, the most abundant nitro-polycyclic aromatic hydrocarbon in the environment, is a known mammalian and bacterial mutagen and a tumorigen in animals. Early studies on DNA adduct characterization for 1-nitropyrene identified N-(deoxyguanos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6477f97ff585c5898e1b53924eaf6c6d
https://doi.org/10.1021/tx00044a600
https://doi.org/10.1021/tx00044a600
Publikováno v:
Chemical Research in Toxicology. 7:806-814
We recently reported that the reaction of N-hydroxy-3-aminobenzo[a] pyrene with calf thymus DNA produced 6-(deoxyguanosin-N2-yl)-3-aminobenzo[a]pyrene as the predominant adduct. The deoxyguanosinyl group of this adduct resides at the C6 position, whi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63b8df8dfb2e2209ae1a7d9f2065cf2e
https://doi.org/10.1021/tx00042a014
https://doi.org/10.1021/tx00042a014
Autor:
Peter P. Fu, Diogenes Herreno-saenz, L. S. Von Tungeln, Jackson O. Lay, Frederick E. Evans, J.-S. Lai, Yu-Sen Wu
Publikováno v:
Environmental Health Perspectives
We have been interested in the structure-activity relationships of nitro-polycyclic aromatic hydrocarbons (nitro-PAHs), and have focused on the correlation of structural and electronic features with biological activities, including mutagenicity and t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f411ee464e6af0b9d0cf8c282ad239ea
https://doi.org/10.1289/ehp.94102s6177
https://doi.org/10.1289/ehp.94102s6177
Autor:
Robert H. Heflicht, Joellen Lewtas, Diogenes Herreno-Saenz, Peter P. Fu, Linda S. Von Tungeln
Publikováno v:
Polycyclic Aromatic Compounds. 6:79-85
In vivo studies of the metabolic activation of 2-nitrofluoranthene (2-NFA) were conducted by incubating Salmonella typhimurium TA98 suspension cultures with 2-NFA (10 or 20μM) for 4 hr. The DNA was isolated and the resulting DNA adducts were analyze
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::380e984e16af132da60d1ab48cc94aab
https://doi.org/10.1080/10406639408031170
https://doi.org/10.1080/10406639408031170
Autor:
Danita G. Ewing, Linda S. Von Tungeln, Robin Weitkamp, Elly Cheng, Peter P. Fu, Diogenes Herreno-Saenz, Fred E. Evans
Publikováno v:
Polycyclic Aromatic Compounds. 7:91-98
2-Nitrobenzo[a]pyrene (2-nitro-BaP) induced 100% liver tumor incidence in the neonatal mouse tumorigenicity assay and exhibited the highest mutagenicity among the 1-, 2-, 3-, and 6-nitro-BaP when tested in Salmonella typhimurium TA98 and TA100. To de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d5304ee98738478f5bf99dc181ba4ed
https://doi.org/10.1080/10406639408014717
https://doi.org/10.1080/10406639408014717
Publikováno v:
Polycyclic Aromatic Compounds. 6:71-78
We have studied in vitro metabolism, DNA adduct formation, mutagenicity, and tumorigenicity of a series of nitro−polycyclic aromatic hydrocarbons. The emphasis has been focused on the isomeric nitrobenzo−[a]pyrenes and related compounds. We have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f54034978423b0d8c652479d84a785e2
https://doi.org/10.1080/10406639408031169
https://doi.org/10.1080/10406639408031169