Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Dinithi Sumanaweera"'
Autor:
Sandun Rajapaksa, Dinithi Sumanaweera, Arthur M Lesk, Lloyd Allison, Peter J Stuckey, Maria Garcia de la Banda, David Abramson, Arun S Konagurthu
Publikováno v:
Bioinformatics. 38:i255-i263
Motivation Alignments are correspondences between sequences. How reliable are alignments of amino acid sequences of proteins, and what inferences about protein relationships can be drawn? Using techniques not previously applied to these questions, by
Autor:
Rik G.H. Lindeboom, Kaylee B. Worlock, Lisa M. Dratva, Masahiro Yoshida, David Scobie, Helen R. Wagstaffe, Laura Richardson, Anna Wilbrey-Clark, Josephine L. Barnes, Krzysztof Polanski, Jessica Allen-Hyttinen, Puja Mehta, Dinithi Sumanaweera, Jacqueline Boccacino, Waradon Sungnak, Ni Huang, Lira Mamanova, Rakesh Kapuge, Liam Bolt, Elena Prigmore, Ben Killingley, Mariya Kalinova, Maria Mayer, Alison Boyers, Alex Mann, Vitor Teixeira, Sam M. Janes, Rachel C. Chambers, Muzlifah Haniffa, Andrew Catchpole, Robert Heyderman, Mahdad Noursadeghi, Benny Chain, Andreas Mayer, Kerstin B. Meyer, Christopher Chiu, Marko Z. Nikolić, Sarah A. Teichmann
The COVID-19 pandemic is an ongoing global health threat, yet our understanding of the cellular disease dynamics remains limited. In our unique COVID-19 human challenge study we used single cell genomics of nasopharyngeal swabs and blood to temporall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d220950228bcc70a9b7e6d3734f32b9f
https://doi.org/10.1101/2023.04.13.23288227
https://doi.org/10.1101/2023.04.13.23288227
Autor:
Dinithi Sumanaweera, Chenqu Suo, Ana-Maria Cujba, Daniele Muraro, Emma Dann, Krzysztof Polanski, Alexander S. Steemers, Woochan Lee, Amanda J. Oliver, Jong-Eun Park, Kerstin B. Meyer, Bianca Dumitrascu, Sarah A. Teichmann
Single-cell data analysis can infer dynamic changes in cell populations, for example across time, space or in response to perturbation. To compare these dynamics between two conditions, trajectory alignment via dynamic programming (DP) optimization i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::332ab57f231f633a9c123b765a34bbbb
https://doi.org/10.1101/2023.03.08.531713
https://doi.org/10.1101/2023.03.08.531713
Autor:
Sandun Rajapaksa, Dinithi Sumanaweera, Maria Garcia de La Banda, Peter Stuckey, David Abramson, Lloyd Allison, Arthur Lesk, Arun Konagurthu
Publikováno v:
2021 IEEE International Conference on Bioinformatics and Biomedicine (BIBM).
Publikováno v:
Bioinformatics
The information criterion of minimum message length (MML) provides a powerful statistical framework for inductive reasoning from observed data. We apply MML to the problem of protein sequence comparison using finite state models with Dirichlet distri
This work demonstrates how a complete statistical model quantifying the evolution of pairs of aligned proteins can be constructed from a time-parameterised substitution matrix and a time-parameterised 3-state alignment machine. All parameters of such
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1f1ff7c70b88a407506bcf6c48ff09a
Publikováno v:
DCC
Comparison of protein sequences via alignment is an important routine in modern biological studies. Although the technologies for aligning proteins are mature, the current state of the art continues to be plagued by many shortcomings, chiefly due to
Publikováno v:
BIBE
Protein function annotation is vital for identifying disease causative factors and for solving mysteries behind biological system complexities. As manual annotation requires costly and laborious in vitro methods, in silico protein function prediction