Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Dingyi Wen"'
Publikováno v:
Analytical Chemistry. 91:13591-13600
Automated Edman degradation for sequencing is the classic tool for determining the N-terminal sequences of proteins. Although it has been complemented or largely replaced by a variety of mass spectrometric methods in recent years, there is no simple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8cc124f7a4c1dd1b8c7e53e7ae73277
https://doi.org/10.1021/acs.analchem.9b02754
https://doi.org/10.1021/acs.analchem.9b02754
Autor:
Heather A Cooke, Dingyi Wen, Chao Quan, Renee I. Shapiro, Martin Preyer, Malgorzata M. Vecchi, Joe Arndt, Susan F. Foley
Publikováno v:
mAbs
Bispecific antibody therapeutics can expand the functionality of a conventional monoclonal antibody drug because they can bind multiple antigens. However, their great potential is counterbalanced by the challenges faced in their production. The class
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9521907760f5fa263499ba9c85d6d0f4
https://doi.org/10.1080/19420862.2018.1519631
https://doi.org/10.1080/19420862.2018.1519631
Autor:
Dingyi Wen, Jana Dolnikova, R. Blake Pepinsky, Malgorzata M. Vecchi, Yongsheng Xiao, Bang Jian Gong
Publikováno v:
Analytical Chemistry. 89:4021-4030
Meteorin and Cometin (Meteorin-like) are secreted proteins belonging to a newly discovered growth factor family. Both proteins play important roles in neural development and may have potential as therapeutic targets or agents. Meteorin and Cometin ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adfc39a3915b4d289dfbe8b59e46bd98
https://doi.org/10.1021/acs.analchem.6b04600
https://doi.org/10.1021/acs.analchem.6b04600
Autor:
Joseph W Arndt, Renée I Shapiro, Abhishek Kulkarni, Blake Pepinsky, Joseph Amatucci, Nels E Pederson, Andreas Lehmann, Dingyi Wen, Joshua W Mugford, Joseph Worrall, Brenda K. Minesinger, Richelle Sopko, Mia Rushe
Publikováno v:
Protein Engineering, Design and Selection
Wnt signaling pathways are required for a wide variety of biological processes ranging from embryonic development to tissue repair and regeneration. Dickkopf-2 (DKK2) is classically defined as a canonical Wnt inhibitor, though it may play a role in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fed8b7226eef308ddaffdc747a627790
https://doi.org/10.1093/protein/gzx007
https://doi.org/10.1093/protein/gzx007
Autor:
Douglas Marcotte, Kerri Spilker, Thomas Hesson, Dingyi Wen, P Rajesh Kumar, Jayanth V. Chodaparambil, Thomas A. Patterson
Publikováno v:
Acta Crystallogr F Struct Biol Commun
Tau proteins play an important role in the proper assembly and function of neurons. Hyperphosphorylation of tau by kinases such as tau tubulin kinase (TTBK) has been hypothesized to cause the aggregation of tau and the formation of neurofibrillary ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2b32cfc43272052f724f30b9ed6470a
https://pubmed.ncbi.nlm.nih.gov/32133995
https://pubmed.ncbi.nlm.nih.gov/32133995
Publikováno v:
Analytical Chemistry. 88:10757-10766
Despite the great success of mass spectrometry (MS) for de novo protein sequencing, Leu and Ile have been generally considered to be indistinguishable by MS because their molecular masses are exactly the same. Positioning of incorrect Leu/Ile residue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e0ac589db4c1ec9ad0fc6c0c2676ab9
https://doi.org/10.1021/acs.analchem.6b03409
https://doi.org/10.1021/acs.analchem.6b03409
Autor:
Andreas Lehmann, Thomas Cameron, Yan Gao, Bang-Jian Gong, Dingyi Wen, Thomas Walz, Joseph Amatucci, Pepinsky R Blake, Martin Bush, Nels E. Pederson, Yaping Sun, Janine Ferrant
Publikováno v:
Biochemistry. 56(33)
Growth differentiation factor 11 (GDF11), a member of the transforming growth factor β (TGF-β) family, plays diverse roles in mammalian development. It is synthesized as a large, inactive precursor protein containing a prodomain, pro-GDF11, and exi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3724beda53ac57b41dc289acbd05bee2
https://pubmed.ncbi.nlm.nih.gov/28715204
https://pubmed.ncbi.nlm.nih.gov/28715204
Autor:
Veronique Bailly, Giovanna Antognetti, Rebecca Kelly, Olivia Orozco, Kathleen Wortham, Yaping Sun, Dian L. Olson, Anne Cheung, Lu Yang, Dingyi Wen, Michele Sanicola
Publikováno v:
European Journal of Cancer. 47:1736-1746
BIIB015 is an immunoconjugate created for the treatment of solid tumours and is currently in Phase I of clinical evaluation. BIIB015 consists of a humanised monoclonal antibody against the Cripto protein carrying a payload, via a hindered disulphide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01423ccec25dcbbfb7641268d70f3844
https://doi.org/10.1016/j.ejca.2011.02.023
https://doi.org/10.1016/j.ejca.2011.02.023
Autor:
Joy Wang, Dingyi Wen, Joseph Amatucci, Lee Walus, Paul H. Weinreb, Fang Qian, Jane K. Relton, Frank Porreca, Werner Meier, Laura Silvian, Ellen Garber, R. Blake Pepinsky, Ruizhong Wang, Craig P. Wildes, Daniel H. S. Lee, Mi‑young Jung
Publikováno v:
Biotechnology and Applied Biochemistry. 57:31-45
NgRI (Nogo-66 receptor) is part of a signalling complex that inhibits axon regeneration in the central nervous system. Truncated soluble versions of NgRI have been used successfully to promote axon regeneration in animal models of spinal-cord injury,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4700c6873ee609d7513dc6fc00e61a3f
https://doi.org/10.1042/ba20100061
https://doi.org/10.1042/ba20100061
Autor:
Jana Dolnikova, Yao-ming Huang, Anurag Khetan, Dingyi Wen, Thomas Ryll, Helena Yusuf-Makagiansar, Paul Chen, Nels E. Pederson
Publikováno v:
Biotechnology and Bioengineering. 107:116-123
A recombinant monoclonal antibody produced by Chinese hamster ovary (CHO) cell fed-batch culture was found to have amino acid sequence misincorporation upon analysis by intact mass and peptide mapping mass spectrometry. A detailed analysis revealed m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30254ebbfe0abf12b2c96f659514d1e9
https://doi.org/10.1002/bit.22771
https://doi.org/10.1002/bit.22771