Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Dingsheng WEN"'
Publikováno v:
Journal of Holistic Integrative Pharmacy, Vol 4, Iss 1, Pp 83-102 (2023)
Background: Presenilin enhancer-2 (PSENEN, PEN-2), one of the four components of the γ-secretase complex, has been increasingly revealed to be significant in cancer types such as pancreatic cancer, gastric cancer, and breast cancer. However, the pan
Externí odkaz:
https://doaj.org/article/6185f1a5c63e4eefb388f1aa8059f8ff
Publikováno v:
In Journal of Holistic Integrative Pharmacy September 2021 2(3):206-220
Development and Validation of LC-MS/MS Method for A15 and its Application in Pharmacokinetic Studies
Autor:
boyu Chen, Dingsheng Wen, JiaHuan Xu, Qianqing Chen, Shuilin Xie, Yanan Bie, HuanXian Wu, Baofang Ou, Shaoyu Wu
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::36d37cccc8e03417b275f218bc96bd2d
https://doi.org/10.2139/ssrn.4305489
https://doi.org/10.2139/ssrn.4305489
Autor:
Dake Cai, Weilan Yu, Dingsheng Wen, Yanping Guan, Haining Gan, Guoping Zhong, Biaochang Lao, Xiaolin Liu, Weibang Yu, Fulin Jiang, Juntao Zheng
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 172:58-66
Curcumin (CUR) is a bioactive compound present in many composite prescriptions of traditional Chinese medicine together with quercetin (QR) and paeoniflorin (PF). Little is known about the influence of QR and PF on the absorption and metabolism of CU
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68f4f9fdd8176e84eec48d8f7059d32d
https://doi.org/10.1016/j.jpba.2019.04.033
https://doi.org/10.1016/j.jpba.2019.04.033
Autor:
Xueding Wang, Chuncao Xu, Min Huang, Liemin Zhou, Hongliang Li, Yibei Chen, Dingsheng Wen, Xupeng Bai, Jing Jin
Publikováno v:
Psychopharmacology. 235:2665-2673
Valproate (VPA) is a choice for the treatment of primary generalized epilepsies and partial epilepsies. Unfortunately, weight gain or obesity is one of the most frequent adverse effects of VPA treatment. Genetic factors were shown to be involved in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e206193a2e3fb79949b8d733da6c361
https://doi.org/10.1007/s00213-018-4960-2
https://doi.org/10.1007/s00213-018-4960-2
Autor:
Xueding Wang, Xiang Peng, Dake Cai, Xiang Gao, Hu Pinjin, Dingsheng Wen, Yujie Gao, Jiangying Chen, Guoping Zhong, Min Huang, Yao Liu, Fulin Jiang, Zhi Min
Publikováno v:
Biomedical chromatography : BMC. 32(8)
An accurate and sensitive LC-MS/MS method for determining thalidomide, 5-hydroxy thalidomide and 5'-hydroxy thalidomide in human plasma was developed and validated using umbelliferone as an internal standard. The analytes were extracted from plasma (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1b311e676279c1ee488038fc9d8d26b
https://pubmed.ncbi.nlm.nih.gov/29529709
https://pubmed.ncbi.nlm.nih.gov/29529709
Autor:
Dingsheng Wen, Hongliang Li, Jiaming Qin, Liemin Zhou, Qiling Dai, Min Huang, Xueding Wang, Juan Chen, Guanzhong Ni, Guoping Zhong, Ziyi Chen, Huanbin Liu, Chao Yang
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 149
Valproic acid(VPA) is a classic drug that used to treat epilepsy in monotherapy or combination with other anticonvulsant drugs such as lamotrigine (LTG). Although it was reported that VPA could increase lamotrigine trough concentration in clinical pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a8d295b2289e35d2b6ba7b2920f0389
https://pubmed.ncbi.nlm.nih.gov/29169113
https://pubmed.ncbi.nlm.nih.gov/29169113
Autor:
John J. Talley, Liu Jianqi, Dingsheng Wen, Lu Xin, Zhengchao Tu, Micky D. Tortorella, Yanmei Zhang, Xiaorong Liu, Wang Yican, Yang Bai, Yongzhi Lu
Publikováno v:
ACS Medicinal Chemistry Letters. 5:1162-1166
We designed a series of specifically deuterated benzopyran analogues as new COX-2 inhibitors with the aim of improving their pharmacokinetic properties. As expected, the deuterated compounds retained potency and selectivity for COX-2. The new molecul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba3e9f87ca285f9c8680afc1e0307307
https://doi.org/10.1021/ml500299q
https://doi.org/10.1021/ml500299q
Autor:
Chan Albert Sun Chi, Caishun Huang, Gui Lu, Dingsheng Wen, Xueding Wang, Liuyun Qin, Zhangwei Li, Zhao Zhenzhen, Min Huang, Zhuoan Deng, Fulin Jiang, Tang Johnny Cheuk On, Jing Guo, Jiangying Chen, Guoping Zhong
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 134
Great attentions have been drawn by quinoline for its broad bioactivity as anti-fungal, anti-bacterial and anti-tumor activities. Compared with cisplatin, 83b1, a quinoline derivative, showed equal activity in anti-tumor and lower cyctotoxicity in no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d350ce30a7913bfae306e1a4281a7f7c
https://pubmed.ncbi.nlm.nih.gov/27886572
https://pubmed.ncbi.nlm.nih.gov/27886572
Publikováno v:
Journal of Applied Toxicology. 32:834-842
Drug-induced QT prolongation usually leads to torsade de pointes (TdP), thus for drugs in the early phase of development this risk should be evaluated. In the present study, we demonstrated a visualized transgenic zebrafish as an in vivo high-through
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99281560dff9ea5b50dbc190e815ad63
https://doi.org/10.1002/jat.2755
https://doi.org/10.1002/jat.2755