Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Dinghai Zheng"'
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-21 (2021)
Abstract Most eukaryotic genes express alternative polyadenylation (APA) isoforms. A growing number of RNA sequencing methods, especially those used for single-cell transcriptome analysis, generate reads close to the polyadenylation site (PAS), terme
Externí odkaz:
https://doaj.org/article/c936850cff8d4b479959056b2950b07e
Autor:
Aysegul Guvenek, Jihae Shin, Lidia De Filippis, Dinghai Zheng, Wei Wang, Zhiping P. Pang, Bin Tian
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
RNA stability plays an important role in gene expression. Here, using 3′ end sequencing of newly made and pre-existing poly(A)+ RNAs, we compare transcript stability in multiple human cell lines, including HEK293T, HepG2, and SH-SY5Y. We show that
Externí odkaz:
https://doaj.org/article/1f93110956ac4d3e99093c2f735deb9c
Autor:
Larry C. Cheng, Dinghai Zheng, Erdene Baljinnyam, Fangzheng Sun, Koichi Ogami, Percy Luk Yeung, Mainul Hoque, Chi-Wei Lu, James L. Manley, Bin Tian
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Alternative polyadenylation generates multiple mRNA isoforms with different 3′ UTR sizes. Here the authors report global 3′ UTR shortening that is coupled to increased expression of secretory pathway genes in secretory cell differentiation.
Externí odkaz:
https://doaj.org/article/930e44d8511440f79f4ea3c291ee5bb2
Autor:
Dinghai Zheng, Ruijia Wang, Qingbao Ding, Tianying Wang, Bingning Xie, Lu Wei, Zhaohua Zhong, Bin Tian
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
The function and consequences of alternative polyadenylation (APA) in stressed cells are largely unclear. Here, the authors show that stress-induced mRNA degradation depends on 3′UTR length and that APA-mediated 3′UTR shortening is an adaptive st
Externí odkaz:
https://doaj.org/article/2d8fedf2c109461cb0a2b230cda92eaa
Autor:
Mariana M. Fontes, Aysegul Guvenek, Riki Kawaguchi, Dinghai Zheng, Alden Huang, Victoria M. Ho, Patrick B. Chen, Xiaochuan Liu, Thomas J. O’Dell, Giovanni Coppola, Bin Tian, Kelsey C. Martin
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract Long-lasting forms of synaptic plasticity that underlie learning and memory require new transcription and translation for their persistence. The remarkable polarity and compartmentalization of neurons raises questions about the spatial and t
Externí odkaz:
https://doaj.org/article/056a72711b3b4b43aa3da7c4e92037c8
Publikováno v:
Cell Reports, Vol 26, Iss 10, Pp 2766-2778.e6 (2019)
Summary: Regulation of cleavage and polyadenylation (CPA) affects gene expression and polyadenylation site (PAS) choice. Here, we report that the CPA and termination factor PCF11 modulates gene expression on the basis of gene size. Although downregul
Externí odkaz:
https://doaj.org/article/3392a7ffc8144a24825e32920a8d0b1c
Autor:
Wencheng Li, Bei You, Mainul Hoque, Dinghai Zheng, Wenting Luo, Zhe Ji, Ji Yeon Park, Samuel I Gunderson, Auinash Kalsotra, James L Manley, Bin Tian
Publikováno v:
PLoS Genetics, Vol 11, Iss 4, p e1005166 (2015)
Alternative cleavage and polyadenylation (APA) results in mRNA isoforms containing different 3' untranslated regions (3'UTRs) and/or coding sequences. How core cleavage/polyadenylation (C/P) factors regulate APA is not well understood. Using siRNA kn
Externí odkaz:
https://doaj.org/article/1a400975ac4d468698a88a3973e03927
Autor:
Ji Yeon Park, Wencheng Li, Dinghai Zheng, Peiyong Zhai, Yun Zhao, Takahisa Matsuda, Stephen F Vatner, Junichi Sadoshima, Bin Tian
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e22391 (2011)
Cardiac hypertrophy is enlargement of the heart in response to physiological or pathological stimuli, chiefly involving growth of myocytes in size rather than in number. Previous studies have shown that the expression pattern of a group of genes in h
Externí odkaz:
https://doaj.org/article/fc0e80bebffd4bd4a66abb985be8e1ef
Autor:
Kubaczka, M. Guillermina, Herz, Micaela A. Godoy, Wei-Chun Chen, Dinghai Zheng, Petrillo, Ezequiel, Bin Tian, Kornblihtt, Alberto R.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 8/20/2024, Vol. 121 Issue 34, p1-10, 25p
Autor:
Cinzia Caggiano, Marco Pieraccioli, Consuelo Pitolli, Gabriele Babini, Dinghai Zheng, Bin Tian, Pamela Bielli, Claudio Sette
Prostate cancer (PC) relies on androgen receptor (AR) signaling. While hormonal therapy (HT) is efficacious, most patients evolve to an incurable castration-resistant stage (CRPC). To date, most proposed mechanisms of acquired resistance to HT have f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4743302bcac8d1102e614747b8d0ca6c
https://hdl.handle.net/2108/329844
https://hdl.handle.net/2108/329844
