Zobrazeno 1 - 10
of 898
pro vyhledávání: '"Ding-Shinn Chen"'
Autor:
Grace Hui-Min Wu, Wen-Wen Yang, Chia-Ling Liu, Raoh-Fang Pwu, Rong-Nan Chien, Po-Chang Lee, Shih-Chung Chen, Ding-Shinn Chen, Sheng-Nan Lu
Publikováno v:
Journal of the Formosan Medical Association, Vol 120, Iss 7, Pp 1444-1451 (2021)
Background/Purpose: This study aims at investigating the epidemiological profile of chronic hepatitis C (CHC) regarding hepatitis C virus (HCV) genotype in Taiwan. Methods: A total of 29,087 CHC patients with advanced fibrosis who received direct-act
Externí odkaz:
https://doaj.org/article/bb77849c7df6442da1c3170f9ddfe4ae
Publikováno v:
Journal of the Formosan Medical Association, Vol 119, Iss 12, Pp 1871-1875 (2020)
Despite the excellent antiviral effects of direct acting antivirals (DAAs) for hepatitis C virus (HCV) infection with subsequent decrease of morbidity and mortality, a small proportion (5%) of the treated patients do not respond to first-line DAAs an
Externí odkaz:
https://doaj.org/article/7236bc32588c4c37a672614b8d71cba1
Autor:
Ching-Sheng Hsu, Wei-Liang Liu, Qisheng Li, Brianna Lowey, Laura Hertz, You-Chen Chao, T. Jake Liang, Ding-Shinn Chen, Jia-Horng Kao
Publikováno v:
Journal of the Formosan Medical Association, Vol 119, Iss 9, Pp 1382-1395 (2020)
Background: Patients with different hepatitis C virus (HCV) genotype infections are associated with varying metabolic disorders. Although alteration of lipid metabolism has been confirmed as a virus-induced metabolic derangement in chronic hepatitis
Externí odkaz:
https://doaj.org/article/7664b93fea174a54ac172da0de9634da
Autor:
Yu-Chan Yang, Yu-Hsiang Chen, Jia-Horng Kao, Chi Ching, I-Jung Liu, Chih-Chiang Wang, Cheng-Hsueh Tsai, Fang-Yi Wu, Chun-Jen Liu, Pei-Jer Chen, Ding-Shinn Chen, Hung-Chih Yang
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 20, Iss , Pp 480-490 (2020)
Current antiviral therapy fails to cure chronic hepatitis B virus (HBV) infection because of persistent covalently closed circular DNA (cccDNA). CRISPR/Cas9-mediated specific cleavage of cccDNA is a potentially curative strategy for chronic hepatitis
Externí odkaz:
https://doaj.org/article/dd9b1aae44ad482ba469310eb3a054bf
Autor:
Jau-Hau Horng, Wei-Hsiang Lin, Chang-Ru Wu, You-Yu Lin, Li-Ling Wu, Ding-Shinn Chen, Pei-Jer Chen
Publikováno v:
Journal of Biomedical Science, Vol 27, Iss 1, Pp 1-16 (2020)
Abstract Background Hepatitis B virus (HBV) persistently infected about 250 million people worldwide, and a curative treatment remains an unmet medical need. Among many approaches to treat chronic hepatitis B (CHB), therapeutic vaccines have been dev
Externí odkaz:
https://doaj.org/article/bc5ae5955993494189e8813b095bacfe
Autor:
Su-Ru Lin, Ta-Yu Yang, Cheng-Yuan Peng, You-Yu Lin, Chia-Yen Dai, Hurng-Yi Wang, Tung-Hung Su, Tai-Chung Tseng, I-Jung Liu, Huei-Ru Cheng, Yueh-Chi Shen, Fang-Yi Wu, Chun-Jen Liu, Ding-Shinn Chen, Pei-Jer Chen, Hung-Chih Yang, Jia-Horng Kao
Publikováno v:
JHEP Reports, Vol 3, Iss 3, Pp 100254- (2021)
Summary: Background & Aims: We aimed to investigate how viral quasispecies of the HBV whole genome evolves and diversifies in response to HBeAg seroconversion and viral control utilising next-generation sequencing (NGS). Methods: Fifty HBeAg-positive
Externí odkaz:
https://doaj.org/article/c38f959d48704517bc685f16fdabf609
Autor:
Shih-Jer Hsu, Min-Chin Chiu, Yu-Jen Fang, Tsung-Hua Yang, Jian-Jyun Yu, Chieh-Chang Chen, Chia-Chi Kuo, Ji-Yuh Lee, Chien-Hung Chen, Ding-Shinn Chen, Jia-Horng Kao
Publikováno v:
Journal of the Formosan Medical Association, Vol 118, Iss 8, Pp 1187-1192 (2019)
Background: Glecaprevir/pibrentasvir (GLE/PIB) is a pangenotypic direct-acting antiviral agent for the treatment of chronic hepatitis C virus (HCV) infection. Real-world data of GLE/PIB in Asian patients other than Japanese are limited. We thus inves
Externí odkaz:
https://doaj.org/article/c5ad001b68694cfa8668d2f2528187dd
Autor:
Ming-Lung Yu, Chao-Hung Hung, Yi-Hsiang Huang, Cheng-Yuan Peng, Chun-Yen Lin, Pin-Nan Cheng, Rong-Nan Chien, Shih-Jer Hsu, Chen-Hua Liu, Chung-Feng Huang, Chien-Wei Su, Jee-Fu Huang, Chun-Jen Liu, Jia-Horng Kao, Wan-Long Chuang, Pei-Jer Chen, Ding-Shinn Chen
Publikováno v:
Journal of the Formosan Medical Association, Vol 118, Iss 2, Pp 556-564 (2019)
Background/Purpose: Treatment with daclatasvir plus asunaprevir (DCV + ASV) for 24 weeks provided a sustained virologic response (SVR) rate of over 90% in hepatitis C virus genotype 1b (HCV-1b) infected patients without non-structural 5A (NS5A) resis
Externí odkaz:
https://doaj.org/article/f24c43ec6afd4084975cae897e35295e
Autor:
Hsing-Yu Chen, Tung-Hung Su, Tai-Chung Tseng, Wan-Ting Yang, Ting-Chih Chen, Pei-Jer Chen, Ding-Shinn Chen, Jia-Horng Kao, Chun-Jen Liu
Publikováno v:
Journal of the Formosan Medical Association, Vol 116, Iss 9, Pp 697-704 (2017)
Occult hepatitis B infection (OHB) is not rare in countries that are endemic for hepatitis B virus (HBV) and in patients with chronic hepatitis C virus (HCV) infection. Notably, OHB has been shown to play a role in the progression of liver diseases,
Externí odkaz:
https://doaj.org/article/a4f60f61afae4ef7bdacfbebc7ddd06d
Autor:
Tung-Hung Su, Chung-Wai Shiau, Ping Jao, Nian-Jie Yang, Wei-Tien Tai, Chun-Jen Liu, Tai-Chung Tseng, Hung-Chih Yang, Chen-Hua Liu, Kai-Wen Huang, Ting-Chen Hu, Yu-Jen Huang, Yao-Ming Wu, Li-Ju Chen, Pei-Jer Chen, Ding-Shinn Chen, Kuen-Feng Chen, Jia-Horng Kao
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract This study aimed to investigate the role of src-homology protein tyrosine phosphatase-1 (SHP-1)–signal transducer and activator of transcription 3 (STAT3) pathway in liver fibrogenesis and the anti-fibrotic effect of SHP-1 agonist. The ant
Externí odkaz:
https://doaj.org/article/3d50e6bc0e2648bebc05dad65df544e8