Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Ding-Quan Qian"'
Autor:
David M. Burns, Chunhong He, Yun-Long Li, Jincong Zhuo, Ding-Quan Qian, Lihua Chen, Ravi Jalluri, Sharon Diamond, Maryanne B. Covington, Yanlong Li, Richard Wynn, Peggy Scherle, Swamy Yeleswaram, Gregory Hollis, Steve Friedman, Brian Metcalf, Wenqing Yao
Publikováno v:
Bioorganicmedicinal chemistry letters. 73
11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) has been identified as the primary enzyme responsible for the activation of hepatic cortisone to cortisol in specific peripheral tissues, resulting in the concomitant antagonism of insulin action within
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbbafe40c80b68974928f2b0a5dbd9bd
https://pubmed.ncbi.nlm.nih.gov/35835377
https://pubmed.ncbi.nlm.nih.gov/35835377
Autor:
Colin, Zhang, Meizhong, Xu, Chunhong, He, Jincong, Zhuo, David M, Burns, Ding-Quan, Qian, Qiyan, Lin, Yun-Long, Li, Lihua, Chen, Eric, Shi, Costas, Agrios, Linkai, Weng, Vaqar, Sharief, Ravi, Jalluri, Yanlong, Li, Peggy, Scherle, Sharon, Diamond, Deborah, Hunter, Maryanne, Covington, Cindy, Marando, Richard, Wynn, Kamna, Katiyar, Nancy, Contel, Kris, Vaddi, Swamy, Yeleswaram, Gregory, Hollis, Reid, Huber, Steve, Friedman, Brian, Metcalf, Wenqing, Yao
Publikováno v:
SSRN Electronic Journal.
11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) has been identified as the primary enzyme responsible for the activation of hepatic cortisone to cortisol in specific peripheral tissues resulting in the concomitant antagonism of insulin action within
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3692552a04b6f880ed62ecd30b202590
https://doi.org/10.2139/ssrn.4056120
https://doi.org/10.2139/ssrn.4056120
Autor:
Maryanne Covington, Ding-Quan Qian, Robert C. Newton, Lynn Leffet, Niu Shin, Peggy Scherle, Kevin Bowman, Kathy Wang, Swamy Yeleswaram, Yanlong Li, Kristin Krug, Wenqing Yao, Jincong Zhuo, Patricia Feldman, Maxim Soloviev, Jing Zhang, Zhijing Hu, Philip Czerniak, Dan Bell, Hui Zhao, Xin He, Di Bian
Publikováno v:
European Journal of Pharmacology. 675:47-56
The histamine H₄ receptor mediates several histamine-induced cellular functions of leukocytes, including cell migration and cytokine production. Recent studies suggest that histamine signaling through the histamine H₄ receptor can also have anti-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b5659081f5ddc92d9c7720440c6ce5b4
https://doi.org/10.1016/j.ejphar.2011.11.027
https://doi.org/10.1016/j.ejphar.2011.11.027
Autor:
Costas Agrios, Brian Metcalf, Lingkai Weng, Ding-Quan Qian, David M. Burns, Yun-Long Li, Jincong Zhuo, Colin Zhang, Meizhong Xu, Qiyan Lin, Chunhong He, Eric Shi, Wenqing Yao
Publikováno v:
Synlett. 2007:0460-0464
An efficient asymmetric synthesis of conformationally constrained (2S,3S)-piperidinedicarboxylic acid derivatives starting from L-aspartic acid β-tert-butyl ester and 3-chloro-2-(chloromethyl)-1-propene is described. The key steps involve N-alkylati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ecff296c2c3f79070f2e572b0dd7cac
https://doi.org/10.1055/s-2007-968029
https://doi.org/10.1055/s-2007-968029
Autor:
Lingkai Weng, Qiyan Lin, Ravi Kumar Jalluri, Eric Shi, Maryanne Covington, Ding-Quan Qian, Peggy Scherle, Timothy Burn, Jordan S. Fridman, Kamna Katiyar, Costas Agrios, Max Pan, Kris Vaddi, Changnian Liu, Zelda Wasserman, Nancy Taylor, Eian Caulder, Wenqing Yao, Robert C. Newton, Gregory Hollis, Steven Friedman, Yanlong Li, Bing-Bing Zhou, Yun-Long Li, Michael J. Bower, Chunhong He, Xiangdong Liu, Colin Zhang, Jincong Zhuo, Meizhong Xu, Swamy Yeleswaram, David M. Burns, Cindy A. Marando, Richard Wynn, Brian Metcalf
Publikováno v:
Journal of Medicinal Chemistry. 50:603-606
The design, synthesis, evaluation, and identification of a novel class of (6S,7S)-N-hydroxy-6-carboxamide-5-azaspiro[2.5]octane-7-carboxamides as the first potent and selective inhibitors of human epidermal growth factor receptor-2 (HER-2) sheddase i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baef3a8ed08b12286d84bda86fa256d1
https://doi.org/10.1021/jm061344o
https://doi.org/10.1021/jm061344o
Autor:
Yun-Long Li, Brian Metcalf, Richard Wynn, Mark Stow, Yanlong Li, Qiyan Lin, Kamna Katiyar, Eric Shi, Costas Agrios, Vaqar Sharief, Lingkai Weng, Reid Huber, Steven M. Friedman, Peggy A. Scherle, Timothy Burn, Xiangdong Liu, Meizhong Xu, Gregory F. Hollis, Colin Zhang, David M. Burns, Dawn Ellis, Robert Newton, Phillip Liu, Cindy Marando, Maryanne B. Covington, Chunhong He, M.C. Hillman, Gengjie Yang, Jincong Zhuo, Mark Rupar, Ding-Quan Qian, Wenqing Yao, Kenneth Abremski, Jodi D. Bradley
Publikováno v:
Cancer Biology & Therapy. 5:657-664
Overexpression and activating mutations of ErbB family members have been implicated in the development and progression of a variety of tumor types. Cleavage of the HER2 receptor by an as yet unidentified ectodomain sheddase has been shown to liberate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c435ae0c30ea356f73c04aba227fa78d
https://doi.org/10.4161/cbt.5.6.2708
https://doi.org/10.4161/cbt.5.6.2708
Autor:
John H. Thurston, Bing-Jun Zhao, Ding Quan Qian, John N. Marx, Kenton H. Whitmire, Henry J. Shine, Ilse Y. Guzman-Jimenez, Teyeb Ould-Ely
Publikováno v:
The Journal of Organic Chemistry. 68:8910-8917
Phenoxathiin cation radical perchlorate (PO.+ClO4(-)) added stereospecifically to cyclopentene, cyclohexene, cycloheptene, and 1,5-cyclooctadiene to give 1,2-bis(5-phenoxathiiniumyl)cycloalkane diperchlorates (4-7) in good yield. The diaxial configur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e45bb95d27527f69adb1c72542f2edf7
https://doi.org/10.1021/jo030173h
https://doi.org/10.1021/jo030173h
Publikováno v:
Journal of Physical Organic Chemistry. 16:142-147
Reactions between 5-(aryl)thianthrenium bromides (1a–e) with aryl (Ar) groups phenyl (a), p-tolyl (b), p-anisyl (c), p-chlorophenyl (d) and p-bromophenyl (e) and sodium aryl oxides (7a–c, Ar′ONa, Ar′ = phenyl, p-tolyl and p-chlorophenyl) were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::066623978cf4409d6d09433c4d31dfe6
https://doi.org/10.1002/poc.585
https://doi.org/10.1002/poc.585
Publikováno v:
Journal of Physical Organic Chemistry. 15:139-147
A series of 5-(aryl)thianthrenium bromides (6a–e) with aryl (Ar) groups phenyl (a), p-tolyl (b), p-anisyl (c), p-chlorophenyl (d) and p-bromophenyl (e) was prepared by reaction of thianthrene 5-oxide with the appropriate Grignard reagent ArMgBr. Re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65827962fc0b6af2c731d3354776018d
https://doi.org/10.1002/poc.462
https://doi.org/10.1002/poc.462
Autor:
Sharon Diamond-Fosbenner, Maryanne B. Covington, Gregory Hollis, Wenqing Yao, Liangxing Wu, Peggy Scherle, Timothy Burn, Sindy Condon, Karen Gallagher, Darlise DiMatteo, Xiaoming Wen, Yan-ou Yang, Michael Hansbury, Richard Wynn, Liang Lu, Phillip C.C. Liu, Swamy Yeleswaram, Ding-Quan Qian, Xin He, Bruce Ruggeri, Matthew C. Stubbs, Ronald M. Klabe, Reid Huber, Kevin Bowman, Paul Collier
Publikováno v:
Cancer Research. 77:2100-2100
Aberrant signaling through Fibroblast Growth Factor Receptors (FGFR) has been reported in multiple types of human cancers. FGFR4 signaling contributes to the development and progression of subsets of cancer: in approximately 10 percent of hepatocellu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2164da163dff7d2e8c674c35d16f306
https://doi.org/10.1158/1538-7445.am2017-2100
https://doi.org/10.1158/1538-7445.am2017-2100