Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Ding Y Liu"'
Publikováno v:
Pharmacology & Toxicology. 86:228-233
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::64454fb58e8dadf4720181a122e2de62
https://doi.org/10.1034/j.1600-0773.2000.pto860506.x
https://doi.org/10.1034/j.1600-0773.2000.pto860506.x
Publikováno v:
Best Practice & Research Clinical Haematology. 15:369-384
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b04c80e86a652e512ba8ad552320c27f
https://doi.org/10.1053/beha.2002.0209
https://doi.org/10.1053/beha.2002.0209
Publikováno v:
Pharmacology and Toxicology. 86:228-233
1-(3'-Hydroxypropyl)-2-methyl-3-hydroxypyridin-4-one (CP41) has been extensively investigated as an orally effective iron chelator. In order to improve the pharmacokinetic and metabolic properties of CP41, eleven aromatic esters have been synthesised
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96d7c9d0ca8f74aac6ad1645c7aa32ec
https://doi.org/10.1034/j.1600-0773.2000.d01-40.x
https://doi.org/10.1034/j.1600-0773.2000.d01-40.x
Publikováno v:
Journal of Medicinal Chemistry. 42:4814-4823
The synthesis of a range of 2-(1'-hydroxyalkyl)-3-hydroxypyridin-4-ones as bidentate iron(III) chelators with potential for oral administration is described. The pK(a) values of the ligands and the stability constants of their iron(III) complexes hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46b21b0de95595bb52be2141775850cd
https://doi.org/10.1021/jm991080o
https://doi.org/10.1021/jm991080o
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 730:135-139
A gradient ion-pair HPLC separation of highly hydrophilic 3-hydroxypyridin-4-one (HPO) iron chelators is described. The ˚ separation of HPOs was performed using a reversed-phase polymer HPLC column (PLRP-S 100 A, 1530.46 cm ID, 5 mm). The ion-pair b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c262e5f23209d77a9ce86a3f7a2965dd
https://doi.org/10.1016/s0378-4347(99)00198-x
https://doi.org/10.1016/s0378-4347(99)00198-x
Publikováno v:
Advances in experimental medicine and biology. 509
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6e5047dcb3540c8aedbb534c3859ace5
https://pubmed.ncbi.nlm.nih.gov/12572993
https://pubmed.ncbi.nlm.nih.gov/12572993
Publikováno v:
Iron Chelation Therapy ISBN: 9780306467851
Iron overload is a serious clinical condition which can be largely prevented by the use of iron-specific chelating agents. Desferrioxamine-B(1)the most widely used iron chelator in haematology over the past thirty years, has a major disadvantage of b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6b55034a0400fc5c99a9c336c6d463d
https://doi.org/10.1007/978-1-4615-0593-8_8
https://doi.org/10.1007/978-1-4615-0593-8_8
Autor:
John W. Gorrod, Ding Y. Liu
Publikováno v:
Drug metabolism and drug interactions. 15(2-3)
The present study investigated some aspects of the enzymology of the in vitro N1-oxidation of 9-benzyladenine (BA) and isomeric 9-(nitrobenzyl)adenines (NBAs) using various potential inducers and inhibitors of cytochrome P-450 (CYP). When incubated w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe206e52ac746a142ef7f1338463af51
https://pubmed.ncbi.nlm.nih.gov/10707120
https://pubmed.ncbi.nlm.nih.gov/10707120
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 21(4)
Hydrophilic 3-hydroxypyridin-4-ones (HPOs), such as 1-(2'-carboxyethyl)-2-methyl-3-hydroxypyridin-4-one (CP38), 1-(3'-hydroxypropyl)-2-methyl-3-hydroxypyridin-4-one (CP41) and 1-(2'-hydroxyethyl)-2-ethyl-3-hydroxypyridin-4-one (CP102), are orally act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64e219d4eb018dcdc706ef4f826ed510
https://pubmed.ncbi.nlm.nih.gov/10701941
https://pubmed.ncbi.nlm.nih.gov/10701941
Autor:
John W. Gorrod, Ding Y. Liu
Publikováno v:
Life sciences. 66(1)
N1-Oxidation is a major metabolic pathway for 9-benzyladenine (BA) catalyzed by the cytochrome P450 system in animal hepatic microsomes. After normal hamster hepatic microsomes or phenobarbital induced rabbit hepatic microsomes were preincubated in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0727ba6ae3802d4ccc91070f101d59eb
https://pubmed.ncbi.nlm.nih.gov/10658926
https://pubmed.ncbi.nlm.nih.gov/10658926