Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Ding Wu Shen"'
Publikováno v:
Experimental Cell Research. 319:566-574
Cisplatin resistance in cancer cells is due to a pleiotropic phenotype transition that allows cells to resist cell death. miRNAs have been shown to be reliable markers of phenotype, critical in cell differentiation, and dysregulated in cancer and oth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9037fa21941cffdf1bd7d2ae24576cd
https://doi.org/10.1016/j.yexcr.2012.10.012
https://doi.org/10.1016/j.yexcr.2012.10.012
Autor:
Ding-Wu Shen, Michael M. Gottesman
Publikováno v:
Pharmaceutical Research. 29:643-650
To determine whether the small endosomal recycling GTPase, RAB8, plays a role in TMEM205-associated resistance to the chemotherapeutic drug cisplatin.Antibodies were used as markers for both genes; confocal microscopy was used to visualize their loca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24a55680e0221cbdb59d93d1079aefee
https://doi.org/10.1007/s11095-011-0562-y
https://doi.org/10.1007/s11095-011-0562-y
Autor:
Baoyun Sun, Juan Lu, Xueyun Gao, Jun-Jie Yin, Yuliang Zhao, Yan Wu, Yingze Wang, Lee Jia, Jie Meng, Ding-Wu Shen, Michael M. Gottesman, Genmei Xing, Chunying Chen, Haiyong He, Xing-Jie Liang, Huan Meng, Paul C. Wang
Publikováno v:
Proceedings of the National Academy of Sciences. 107:7449-7454
Cisplatin is a chemotherapeutic drug commonly used in clinics. However, acquired resistance confines its application in chemotherapeutics. To overcome the acquired resistance to cisplatin, it is reasoned, based on our previous findings of mediation o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c5151be5e86406441469c1ea54e3c32
https://doi.org/10.1073/pnas.0909707107
https://doi.org/10.1073/pnas.0909707107
Autor:
Adorjan Aszalos, Jun-Jie Yin, Ding Wu Shen, Michael M. Gottesman, Toren Finkel, Xing-Jie Liang
Publikováno v:
Molecular Cancer Research. 6:1499-1506
Tumors frequently develop resistance to cisplatin, a platinum drug used as a cornerstone of present-day chemotherapy regimens, significantly decreasing its usefulness in the clinic. Although it is known that cisplatin-resistant (CP-r) cancer cells co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82ded12dd9b590cc7233ee73a4e68ada
https://doi.org/10.1158/1541-7786.mcr-07-2130
https://doi.org/10.1158/1541-7786.mcr-07-2130
Autor:
Xing-Jie Liang, Frederick R. Maxfield, Ding-Wu Shen, Michael M. Gottesman, Sushmita Mukherjee
Publikováno v:
Cancer Research. 66:2346-2353
The clinical utility of cisplatin to treat human malignancies is often limited by the development of drug resistance. We have previously shown that cisplatin-resistant human KB adenocarcinoma cells that are cross-resistant to methotrexate and heavy m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa27cf01a6f8ef35f9eaababbf11dea9
https://doi.org/10.1158/0008-5472.can-05-3436
https://doi.org/10.1158/0008-5472.can-05-3436
Publikováno v:
Journal of Inorganic Biochemistry. 98:1599-1606
The resistance of tumors to cisplatin remains a major cause of treatment failure in cancer patients. Multiple, simultaneous alterations are frequently encountered in cancer cells selected for cisplatin resistance. To determine whether the complex phe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3e9aaeca728207b030a1ef0aea3c999
https://doi.org/10.1016/j.jinorgbio.2004.05.015
https://doi.org/10.1016/j.jinorgbio.2004.05.015
Publikováno v:
Molecular Pharmacology. 66:789-793
Cisplatin resistant (CP-r) cells often show decreased uptake of cisplatin in association with reduced cell surface proteins and decreased endocytosis. In this report, two major [14C]carboplatin-binding proteins were identified as filamin and actin by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ba5b72483da88acaa3c904c582b0df8
https://doi.org/10.1124/mol.66.4.789
https://doi.org/10.1124/mol.66.4.789
Publikováno v:
Journal of Cellular Physiology. 196:63-69
Intrinsic or acquired resistance to cisplatin in cancer cells remains a major obstacle to successful chemotherapy. The clinically relevant genetic and molecular mechanisms of resistance have not yet been identified. Cisplatin-resistant (CP-r) human K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5ff09a62df21c33bb332b81a1030b72
https://doi.org/10.1002/jcp.10320
https://doi.org/10.1002/jcp.10320
Publikováno v:
Journal of Cellular Physiology. 183:108-116
We have isolated cisplatin-resistant human liver carcinoma (7404-CP20) cells with reduced accumulation of cisplatin and other drugs (methotrexate, arsenate, and arsenite) to which these cells are cross-resistant. To determine whether the reduction of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::995cc9fdca34f827eb72b889c42e30b5
https://doi.org/10.1002/(sici)1097-4652(200004)183:1<108::aid-jcp13>3.0.co
https://doi.org/10.1002/(sici)1097-4652(200004)183:1<108::aid-jcp13>3.0.co
Publikováno v:
Experimental Cell Research. 226:133-139
The BEL7404 human hepatoma cell line was selectedin vitrofor primary cisplatin resistance. A panel of four cisplatin-resistant sublines were generated which exhibited resistance to cisplatin (up to 34-fold) but were not cross-resistant to adriamycin,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd4da2e0b8314d080f22646bdbff44be
https://doi.org/10.1006/excr.1996.0211
https://doi.org/10.1006/excr.1996.0211