Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Ding Ren Shen"'
Autor:
Alaric J. Dyckman, Lois D. Lehman-McKeeman, Huadong Sun, Hong Shi, Mary Ellen Cvijic, Ding Ren Shen, Xiaoxia Yang, Michael Yang, Tracy L. Taylor, Hai-Yun Xiao, Zili Xiao, Luisa Salter-Cid, Jian Pang, Percy H. Carter, Paul Levesque, Arvind Mathur, John L. Gilmore, Jenny Xie, T. G. Murali Dhar, Georgia Cornelius, Anthony M. Marino, Kim W. McIntyre, Bethanne M. Warrack
Publikováno v:
Journal of Medicinal Chemistry. 64:1454-1480
Sphingosine-1-phosphate (S1P) binds to a family of sphingosine-1-phosphate G-protein-coupled receptors (S1P1-5). The interaction of S1P with these S1P receptors has a fundamental role in many physiological processes in the vascular and immune systems
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c93ac373a666f79bb2e7b408fdbd2fc
https://doi.org/10.1021/acs.jmedchem.0c01109
https://doi.org/10.1021/acs.jmedchem.0c01109
Autor:
John L. Gilmore, Kim W. McIntyre, Lois D. Lehman-McKeeman, David Marcoux, Hai-Yun Xiao, Georgia Cornelius, Alaric J. Dyckman, Mary Ellen Cvijic, Jenny Xie, Yang Michael G, T. G. Murali Dhar, Zili Xiao, Tracy L. Taylor, Anthony M. Marino, Ding Ren Shen, Percy H. Carter, Paul Levesque, Arvind Mathur, Huadong Sun, Hong Shi
Publikováno v:
ACS Med Chem Lett
[Image: see text] Efforts aimed at increasing the in vivo potency and reducing the elimination half-life of 1 and 2 led to the identification of aryl ether and thioether-derived bicyclic S1P(1) differentiated modulators 3–6. The effects of analogs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::415fc075f357363f95afa2908797c5ae
https://doi.org/10.1021/acsmedchemlett.0c00333
https://doi.org/10.1021/acsmedchemlett.0c00333
Autor:
Lloyd Lecureux, Elizabeth M. Heimrich, Rochelle Thomas, Lois D. Lehman-McKeeman, Hai-Yun Xiao, Georgia Cornelius, Zheng Yang, Alaric J. Dyckman, Anuradha Gupta, Percy H. Carter, Yu-Wen Li, Paul Levesque, Tracy L. Taylor, Zili Xiao, Mary Ellen Cvijic, Arvind Mathur, John L. Gilmore, Lei Gong, Jenny Xie, Marta Dabros, Ding Ren Shen, Xiaoxia Yang, T. G. Murali Dhar, Xia D. Zhou, Yang Michael G, Bala Pragalathan, Huadong Sun, Anthony M. Marino, Hong Shi, Dauh-Rurng Wu, Richard Rampulla, Kim W. McIntyre, Cliff Chen, Luisa Salter-Cid, Bethanne M. Warrack, Celia D’Arienzo, Virna Borowski
Publikováno v:
Journal of Medicinal Chemistry. 62:2265-2285
Recently, our research group reported the identification of BMS-986104 (2) as a differentiated S1P1 receptor modulator. In comparison to fingolimod (1), a full agonist of S1P1 currently marketed for the treatment of relapse remitting multiple scleros
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15b124723f06570a19365c4eb5d204b0
https://doi.org/10.1021/acs.jmedchem.8b01695
https://doi.org/10.1021/acs.jmedchem.8b01695
Autor:
John L, Gilmore, Hai-Yun, Xiao, T G Murali, Dhar, Michael, Yang, Zili, Xiao, Xiaoxia, Yang, Tracy L, Taylor, Kim W, McIntyre, Bethanne M, Warrack, Hong, Shi, Paul C, Levesque, Anthony M, Marino, Georgia, Cornelius, Arvind, Mathur, Ding Ren, Shen, Jian, Pang, Mary Ellen, Cvijic, Lois D, Lehman-McKeeman, Huadong, Sun, Jenny, Xie, Luisa, Salter-Cid, Percy H, Carter, Alaric J, Dyckman
Publikováno v:
Journal of medicinal chemistry. 64(3)
Sphingosine-1-phosphate (S1P) binds to a family of sphingosine-1-phosphate G-protein-coupled receptors (S1P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b171f99d63546ff1524adf2df0c96fa6
https://pubmed.ncbi.nlm.nih.gov/33492963
https://pubmed.ncbi.nlm.nih.gov/33492963
Autor:
Bin Jiang, Sylwia Stachura, T. G. Murali Dhar, Carolyn A. Weigelt, Dauh Rurng Wu, Jingwu Duan, Luisa M. Salter–Cid, Javed Khan, Ding Ren Shen, Melissa Yarde, Qihong Zhao, Zhonghui Lu, Percy H. Carter, John S. Sack, Max Ruzanov
Publikováno v:
Bioorganicmedicinal chemistry letters. 30(19)
In an effort to discover oral inverse agonists of RORγt to treat inflammatory diseases, a new 2,6–difluorobenzyl ether series of cyclopentyl sulfones were found to be surprisingly more potent than the corresponding alcohol derivatives. When combin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79d78507decbe1c2b5ea2335c53b8ab6
https://pubmed.ncbi.nlm.nih.gov/32736080
https://pubmed.ncbi.nlm.nih.gov/32736080
Autor:
Alaric Dyckman, Jenny Xie, Lois D Lehman-McKeeman, Marn Ellen Cvijic, Ding Ren Shen, Dauh-Rurng Wu, Arvind Mathur, Georgia Cornelius, Anthony Marino, Paul Levesque, Hong Shi, Andres Hernandez, David Marcoux, Michael Yang, T. G. Murali Dhar, Hai-Yun Xiao, John Lodge Gilmore
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07f19bf75ab5a1d51b52f15362ce3665
https://doi.org/10.1021/scimeetings.0c02440
https://doi.org/10.1021/scimeetings.0c02440
Autor:
Celia D’Arienzo, Ananta Karmakar, Marta Dabros, Michael Galella, Jingwu Duan, John S. Sack, Dhanya Kumar Raut, David S. Weinstein, Andrew T. Pudzianowski, Ding-Ren Shen, Sylwia Stachura, Joel C. Barrish, Arun Kumar Gupta, Huadong Sun, William R. Foster, Javed Khan, Melissa Yarde, Dan Camac, Lauren Haque, Qihong Zhao, Dauh-Rurng Wu, Carolyn A. Weigelt, Faye Wang, Percy H. Carter, Luisa Salter-Cid, Hemalatha Hemagiri, Jenny Xie, T. G. Murali Dhar, Zhonghui Lu, Virna Borowski, Hua Gong, John E. Somerville
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:85-93
We disclose the optimization of a high throughput screening hit to yield benzothiazine and tetrahydroquinoline sulfonamides as potent RORγt inverse agonists. However, a majority of these compounds showed potent activity against pregnane X receptor (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc1f582e5622499ffe28a2c4e0122b0d
https://doi.org/10.1016/j.bmcl.2017.12.006
https://doi.org/10.1016/j.bmcl.2017.12.006
Autor:
Marta Dabros, Paul Levesque, Elizabeth M. Heimrich, Arvind Mathur, Percy H. Carter, Richard Rampulla, Anuradha Gupta, Lois D. Lehman-McKeeman, Huadong Sun, David Marcoux, Ding Ren Shen, Xiaoxia Yang, Xia D. Zhou, Hai-Yun Xiao, Dauh-Rurng Wu, Louis J. Lombardo, Hong Shi, Zheng Yang, Mary Ellen Cvijic, Alaric J. Dyckman, Kim W. McIntyre, Luisa Salter-Cid, Celia D’Arienzo, Anthony M. Marino, Bala Pragalathan, Georgia Cornelius, Jenny Xie, T. G. Murali Dhar, Tracy L. Taylor, Rochelle Thomas
Publikováno v:
MedChemComm. 8:725-729
Recently, our research group reported the identification of prodrug amino-alcohol 2 as a potent and efficacious S1P1 receptor modulator. This molecule is differentiated preclinically over the marketed drug fingolimod (Gilenya 1), whose active phospha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d2e68634039d58468401fb206f57908e
https://doi.org/10.1039/c6md00539j
https://doi.org/10.1039/c6md00539j
Autor:
Ding Ren Shen, Mary Ellen Cvijic, Hai-Yun Xiao, Alaric J. Dyckman, Yu-Wen Li, Bala Pragalathan, Joel C. Barrish, Georgia Cornelius, Peng Li, Tracy L. Taylor, Zili Xiao, Lois D. Lehman-McKeeman, Jianlin Feng, Dauh-Rurng Wu, John L. Gilmore, Percy H. Carter, David Marcoux, Zheng Yang, Arvind Mathur, Elizabeth M. Heimrich, Kim W. McIntyre, Bethanne M. Warrack, Anuradha Gupta, Yang Michael G, Luisa Salter-Cid, Praveen Balimane, Virna Borowski, Jenny Xie, T. G. Murali Dhar, Alda Fernandes, Anthony M. Marino
Publikováno v:
Journal of Medicinal Chemistry. 59:11138-11147
We describe a highly efficient route for the synthesis of 4a (BMS-986104). A key step in the synthesis is the asymmetric hydroboration of trisubstituted alkene 6. Particularly given the known difficulties involved in this type of transformation (6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec587a5bf6e33d17913adf16699fae01
https://doi.org/10.1021/acs.jmedchem.6b01433
https://doi.org/10.1021/acs.jmedchem.6b01433
Autor:
John S. Sack, Sylwia Stachura, Bin Jiang, Sridhar Vanteru, Percy H. Carter, Lisa Zhang, Max Ruzanov, Javed Khan, Zhonghui Lu, Jenny Xie, Jingwu Duan, Qihong Zhao, Ding-Ren Shen, Luisa Salter-Cid, T. G. Murali Dhar, Dauh-Rurng Wu, Arvind Mathur, David J. Shuster, Virna Borowski, Arun Kumar Gupta, Carolyn A. Weigelt, Michael Galella, William R. Foster, Melissa Yarde
[Image: see text] A new phenyl (3-phenylpyrrolidin-3-yl)sulfone series of RORγt inverse agonists was discovered utilizing the binding conformation of previously reported bicyclic sulfonamide 1. Through a combination of structure-based design and str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::291851fb8201f5b23025040c19f28f3e
https://europepmc.org/articles/PMC6421587/
https://europepmc.org/articles/PMC6421587/