Zobrazeno 1 - 10
of 95
pro vyhledávání: '"Dinesh V Patel"'
Autor:
Sheila Ranganath, Ashok Bhandari, Nicole Avitahl-Curtis, Jaimee McMahon, Derek Wachtel, Jenny Zhang, Christopher Leitheiser, Sylvie G Bernier, Guang Liu, Tran T Tran, Herodion Celino, Jenny Tobin, Joon Jung, Hong Zhao, Katie E Glen, Chris Graul, Aliesha Griffin, Wayne C Schairer, Carolyn Higgins, Tammi L Reza, Eva Mowe, Sam Rivers, Sonya Scott, Alex Monreal, Courtney Shea, Greg Bourne, Casey Coons, Adaline Smith, Kim Tang, Ramya A Mandyam, Jaime Masferrer, David Liu, Dinesh V Patel, Angelika Fretzen, Craig A Murphy, G Todd Milne, Mark L Smythe, Kenneth E Carlson
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0141330 (2015)
Interleukin-6 (IL-6) is an important member of the cytokine superfamily, exerting pleiotropic actions on many physiological processes. Over-production of IL-6 is a hallmark of immune-mediated inflammatory diseases such as Castleman's Disease (CD) and
Externí odkaz:
https://doaj.org/article/79b1eaa807e1438c8eaa8708c553dbc5
Autor:
Vinh Tran, Sampath K. Anandan, Dawn Chen, Zung N. Do, James Sabry, Heather K. Webb, Randall Whitcomb, Richard D. Gless, Euan MacIntyre, Dinesh V. Patel
Publikováno v:
Journal of Clinical Pharmacology
Journal of Clinical Pharmacology, Wiley, 2012, 52, pp.319-328
Journal of Clinical Pharmacology, Wiley, 2012, 52, pp.319-328
AR9281, a potent and selective inhibitor of soluble epoxide hydrolase (s-EH), is in clinical development targeting hypertension and type 2 diabetes. The safety, pharmacokinetics, and pharmacodynamics of AR9281 were evaluated in double-blind, randomiz
Autor:
Kathy White, Zung N. Do, Upasana Mehra, D. Euan MacIntyre, Joanna Waszczuk, Heather Kay Webb, Bruce D. Hammock, Basker R Aavula, James Sabry, Paul D. Jones, Dawn Chen, Sampath-Kumar Anandan, Dinesh V. Patel, Sylvaine Cases, Vinh Tran, Ying Cheng, Richard D. Gless, Jon Vincelette, Le-Ning Zhang, Yi-Xin Jim Wang, Randall Whitcomb, Kenneth R Wong
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:983-988
1-(1-Acetyl-piperidin-4-yl)-3-adamantan-1-yl-urea 14a (AR9281), a potent and selective soluble epoxide hydrolase inhibitor, was recently tested in a phase 2a clinical setting for its effectiveness in reducing blood pressure and improving insulin resi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:1066-1070
Inhibition of soluble epoxide hydrolase has been proposed as a promising new pharmaceutical target for diseases involving hypertension and vascular inflammation. The most potent sEH inhibitors reported to date contain a urea or amide moiety as the ce
Autor:
Priyadarshini Jaishankar, Dinesh V. Patel, Adam R. Renslo, Mikhail F. Gordeev, C. Hackbarth, Sara L. Lopez, Revathy Venkatachalam
Publikováno v:
Journal of Medicinal Chemistry. 48:5009-5024
The oxazolidinones are a new class of synthetic antibacterials effective against a broad range of pathogenic Gram-positive bacteria, including multi-drug-resistant strains. Linezolid is the first drug from this class to reach the market and has becom
Autor:
John S. Ward, Dinesh V. Patel, Mark R. Bray, Sampath-Kumar Anandan, Xiao-Xi Xiao, Richard Brokx
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:1969-1972
Inhibitors of histone deacetylases (HDAC) are emerging as a promising class of anti-cancer agents. A mercaptoamide functionality was designed as a bidentate zinc chelator and incorporated into the hydroxamic acid based SAHA (1) scaffold in order to i
Autor:
Janice M. Friis, Charlotte Wu, Sara E. Morin, Joaquim Trias, Bore Raju, Wade J. Adams, Ford Charles W, Ronda D. Schaadt, Stuart Lam, Joe Palandra, Dinesh V. Patel, Joseph Zhou, Maria Courtney, Mikhail F. Gordeev, Sara Lopez, Gary E. Zurenko, C J Hackbarth, Upinder Singh, Robert C. Gadwood, Zhengyu Yuan, Kathleen Mortell
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:4209-4212
Combinatorial libraries of N-acylated 5-(S)-aminomethyloxazolidinone derivatives of S-oxide and S,S-dioxide tetrahydro-4(2H)-thiopyranyl and thiomorpholine phenyloxazolidinone series have been synthesized on a solid phase and evaluated for antimicrob
Autor:
Gary W. Luehr, Jonathan M. Evans, Gage James R, Barbachyn Michael R, Joaquim Trias, Christian N. Parker, Lee S. Banitt, Gary E. Zurenko, Sara E. Morin, Dinesh V. Patel, Mikhail F. Gordeev, C. Hackbarth, Richard White, Marcela Gomez
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:4213-4216
Antimicrobial compounds incorporating oxazolidinone and quinolone pharmacophore substructures have been synthesized and evaluated. Representative analogues 2, 5, and 6 display an improved potency versus linezolid against gram-positive and fastidious
Autor:
C. Hackbarth, Wen Wang, Charlotte Wu, Rakesh K. Jain, Dinesh V. Patel, A. Sundram, Richard C. White, Sara Lopez, Joaquim Trias, Dawn Chen, Zhengyu Yuan, G. Neckermann, Beat Weidmann, Neil S. Ryder
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:4223-4228
We report the synthesis and biological activity of analogues of VRC3375 (N-hydroxy-3-R-butyl-3-[(2-S-(tert-butoxycarbonyl)-pyrrolidin-1-ylcarbonyl]propionamide), an orally active peptide deformylase inhibitor. This study explores the structure–acti
Autor:
Dinesh V. Patel, Wen Wang, Joaquim Trias, Geoffrey B. Dreyer, Charlotte Wu, Peter S. Margolis, C. Hackbarth, Zhengyu Yuan, Richard White, Zi-Jie Ni, Dawn Chen, Dennis C. Young
Publikováno v:
Biochemistry. 39:1256-1262
Peptide deformylase (PDF) is essential in prokaryotes and absent in mammalian cells, thus making it an attractive target for the discovery of novel antibiotics. We have identified actinonin, a naturally occurring antibacterial agent, as a potent PDF