Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Dinesh P, de Alwis"'
Autor:
Tara C. Gangadhar, Keaven M. Anderson, Scot Ebbinghaus, S. Peter Kang, Jin Zhang, Andrea Perrone, Dinesh P. de Alwis, Amita Patnaik, Jeffrey S. Weber, Peter Hersey, Roxana Dronca, Adil Daud, Caroline Robert, Omid Hamid, F. Stephen Hodi, Antoni Ribas, Anthony M. Joshua, Jedd D. Wolchok, Wen-Jen Hwu, Richard Kefford, Jeroen Elassaiss-Schaap, Richard W. Joseph
Supplemental Table
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26176e6e3787608edb4bcad0a45a1799
https://doi.org/10.1158/1078-0432.22468532.v1
https://doi.org/10.1158/1078-0432.22468532.v1
Autor:
Tara C. Gangadhar, Keaven M. Anderson, Scot Ebbinghaus, S. Peter Kang, Jin Zhang, Andrea Perrone, Dinesh P. de Alwis, Amita Patnaik, Jeffrey S. Weber, Peter Hersey, Roxana Dronca, Adil Daud, Caroline Robert, Omid Hamid, F. Stephen Hodi, Antoni Ribas, Anthony M. Joshua, Jedd D. Wolchok, Wen-Jen Hwu, Richard Kefford, Jeroen Elassaiss-Schaap, Richard W. Joseph
Supplemental Figure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a18324eda47ea878342d3c1bbc476eab
https://doi.org/10.1158/1078-0432.22468538
https://doi.org/10.1158/1078-0432.22468538
All data used for quantitative analysis in review, with links to references and additional details
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6339ad59a91442d5e741d5b402bf505d
https://doi.org/10.1158/1078-0432.22458371
https://doi.org/10.1158/1078-0432.22458371
Autor:
Tara C. Gangadhar, Keaven M. Anderson, Scot Ebbinghaus, S. Peter Kang, Jin Zhang, Andrea Perrone, Dinesh P. de Alwis, Amita Patnaik, Jeffrey S. Weber, Peter Hersey, Roxana Dronca, Adil Daud, Caroline Robert, Omid Hamid, F. Stephen Hodi, Antoni Ribas, Anthony M. Joshua, Jedd D. Wolchok, Wen-Jen Hwu, Richard Kefford, Jeroen Elassaiss-Schaap, Richard W. Joseph
Purpose: The purpose of this study was to assess the association of baseline tumor size (BTS) with other baseline clinical factors and outcomes in pembrolizumab-treated patients with advanced melanoma in KEYNOTE-001 (NCT01295827).Experimental Design:
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::558661f46534a160d0f58b8432cced12
https://doi.org/10.1158/1078-0432.c.6526982.v1
https://doi.org/10.1158/1078-0432.c.6526982.v1
Autor:
Tara C. Gangadhar, Keaven M. Anderson, Scot Ebbinghaus, S. Peter Kang, Jin Zhang, Andrea Perrone, Dinesh P. de Alwis, Amita Patnaik, Jeffrey S. Weber, Peter Hersey, Roxana Dronca, Adil Daud, Caroline Robert, Omid Hamid, F. Stephen Hodi, Antoni Ribas, Anthony M. Joshua, Jedd D. Wolchok, Wen-Jen Hwu, Richard Kefford, Jeroen Elassaiss-Schaap, Richard W. Joseph
Figure legends for supplemental figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c73bef84a8d535a428e2124f7d23a8e
https://doi.org/10.1158/1078-0432.22468544
https://doi.org/10.1158/1078-0432.22468544
One of the key objectives of oncology first-in-human trials has often been to establish the maximum tolerated dose (MTD). However, targeted therapies might not exhibit dose-limiting toxicities (DLT) at doses significantly higher than sufficiently act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::947f91edac40e2951651dbeff85fcedc
https://doi.org/10.1158/1078-0432.c.6523925
https://doi.org/10.1158/1078-0432.c.6523925
Autor:
Julie A. Stone, Dinesh P. de Alwis, Vikram Sinha, Scot W. Ebbinghaus, Jiannan Kang, Kapil Mayawala, Lokesh Jain, Jonathan Wesley Riess, Edward B. Garon, Andrew G. Robinson, Keaven M. Anderson, Anna G. Kondic, David C. Turner
Purpose:To investigate the relationship of pembrolizumab pharmacokinetics (PK) and overall survival (OS) in patients with advanced melanoma and non–small cell lung cancer (NSCLC).Patients and Methods:PK dependencies in OS were evaluated across thre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09f3b10f95f934a74bdc0c2752ee8535
https://doi.org/10.1158/1078-0432.c.6527232
https://doi.org/10.1158/1078-0432.c.6527232
Autor:
Julie A. Stone, Dinesh P. de Alwis, Vikram Sinha, Scot W. Ebbinghaus, Jiannan Kang, Kapil Mayawala, Lokesh Jain, Jonathan Wesley Riess, Edward B. Garon, Andrew G. Robinson, Keaven M. Anderson, Anna G. Kondic, David C. Turner
Fig S1. Kaplan-Meier plots of overall survival, stratified by pembrolizumab dose, demonstrate similarity of efficacy across a 5-fold dose range (2 to 10 mg/kg Q3W) in A) advanced ipilimumab-refractory melanoma, KEYNOTE-002 (Cox HR 0.98; 95% CI 0.94-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f910e21ebcdd3b23a856066a36bafd2
https://doi.org/10.1158/1078-0432.22469358
https://doi.org/10.1158/1078-0432.22469358
Publikováno v:
Annals of Oncology. 32:1618-1625
Background Disease progression is often considered a binary state reflecting presence or absence of response. Meaningful heterogeneity between metastatic sites of a given patient may exist, however, and may impact therapeutic outcomes. To characteriz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb146fccded421d6824f4595b75f2cb3
https://doi.org/10.1016/j.annonc.2021.09.006
https://doi.org/10.1016/j.annonc.2021.09.006
Autor:
Dinesh P. de Alwis, Rukmini Kumar, Brian Topp, Liming Liu, Kannan Thiagarajan, Kapil Mayawala, Lakshmanan Jagannathan
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 7, Pp 684-695 (2021)
CPT: Pharmacometrics & Systems Pharmacology
CPT: Pharmacometrics & Systems Pharmacology
A quantitative systems pharmacology model for metastatic melanoma was developed for immuno‐oncology with the goal of predicting efficacy of combination checkpoint therapy with pembrolizumab and ipilimumab. This literature‐based model is developed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0aeecbd1b7bbe40c43eea6c165b2034b
https://doi.org/10.1002/psp4.12637
https://doi.org/10.1002/psp4.12637