Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Dinesh M. Fernando"'
Autor:
Shivendra Singh, Ahmed Abu-Zaid, Wenwei Lin, Jonathan Low, Alireza Abdolvahabi, Hongjian Jin, Qiong Wu, Bailey Cooke, Jie Fang, John Bowling, Sivaraja Vaithiyalingam, Duane Currier, Mi-Kyung Yun, Dinesh M. Fernando, Julie Maier, Heather Tillman, Purva Bulsara, Zhaohua Lu, Sourav Das, Anang Shelat, Zhenmei Li, Brandon Young, Richard Lee, Zoran Rankovic, Andrew J. Murphy, Stephen W. White, Andrew M. Davidoff, Taosheng Chen, Jun Yang
Publikováno v:
iScience, Vol 24, Iss 1, Pp 101996- (2021)
Summary: Histone lysine demethylases (KDMs) play critical roles in oncogenesis and therefore may be effective targets for anticancer therapy. Using a time-resolved fluorescence resonance energy transfer demethylation screen assay, in combination with
Externí odkaz:
https://doaj.org/article/06c582be98bb44abbf752e112dc13534
Autor:
Ayush Kumar, Dinesh M. Fernando
Publikováno v:
Antibiotics, Vol 2, Iss 1, Pp 163-181 (2013)
Resistance-Nodulation-Division (RND) efflux pumps are one of the most important determinants of multidrug resistance (MDR) in Gram-negative bacteria. With an ever increasing number of Gram-negative clinical isolates exhibiting MDR phenotypes as a res
Externí odkaz:
https://doaj.org/article/e34c0cc9df4847b8865bdd05136b43b1
Autor:
Dinesh M Fernando, Izhar IU Khan, Rakesh Patidar, David Lapen, Guylaine Talbot, Ed Topp, Ayush Kumar
Publikováno v:
Frontiers in Microbiology, Vol 7 (2016)
Acinetobacter baumannii, a Gram-negative opportunistic pathogen, is known to cause multidrug resistant infections. This organism has primarily been isolated from clinical environments and its environmental reservoirs remain largely unknown. In the pr
Externí odkaz:
https://doaj.org/article/1399fd48e23e42648799bd484dc6748b
Autor:
Ahmed Abu-Zaid, Sivaraja Vaithiyalingam, Brandon Young, Sourav Das, Heather Tillman, Bailey Cooke, Alireza Abdolvahabi, Julie Maier, Jonathan Low, Taosheng Chen, Jun J. Yang, Andrew M. Davidoff, Zhenmei Li, John J. Bowling, Hongjian Jin, Shivendra V. Singh, Jie Fang, Purva Bulsara, Wenwei Lin, Zoran Rankovic, Duane G. Currier, Andrew J. Murphy, Zhaohua Lu, Richard E. Lee, Anang A. Shelat, Dinesh M. Fernando, Qiong Wu, Stephen W. White, Mi-Kyung Yun
Publikováno v:
iScience
iScience, Vol 24, Iss 1, Pp 101996-(2021)
iScience, Vol 24, Iss 1, Pp 101996-(2021)
Summary Histone lysine demethylases (KDMs) play critical roles in oncogenesis and therefore may be effective targets for anticancer therapy. Using a time-resolved fluorescence resonance energy transfer demethylation screen assay, in combination with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfc8fae1c6e40b2ac715a77fb2977e6c
http://europepmc.org/articles/PMC7811140
http://europepmc.org/articles/PMC7811140
Autor:
Elizabeth C. Griffith, Richard E. Lee, Rajendra P. Tangallapally, Laura A. Wilt, Christopher J. Meyer, Darcie J. Miller, Clifford T. Gee, Miranda J. Wallace, Dinesh M. Fernando
Publikováno v:
Tuberculosis (Edinb)
The peptide binding protein DppA is an ABC transporter found in prokaryotes that has the potential to be used as drug delivery tool for hybrid antibiotic compounds. Understanding the motifs and structures that bind to DppA is critical to the developm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c992e498ddea581566c3c6487c341c19
https://doi.org/10.1016/j.tube.2021.102157
https://doi.org/10.1016/j.tube.2021.102157
Autor:
Dinesh M. Fernando, Julian G Hurdle, Martin N. Cheramie, Richard E. Lee, Ravi K. R. Marreddy, Philip T. Cherian
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:3105-3112
β-Lactams are the most important class of antibiotics, for which the emergence of resistance threatens their utility. As such, we explored the extent to which the tetramic acid motif, frequently found in naturally occurring antibiotics, can be used
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71bf5ca927a080d7c564be644cccc42a
https://doi.org/10.1016/j.bmcl.2018.07.018
https://doi.org/10.1016/j.bmcl.2018.07.018
Autor:
Elizabeth C. Griffith, Miranda J. Wallace, Stephanie M. Reeve, Clifford T. Gee, Gregory A. Phelps, Robin B. Lee, John M Elmore, Jiangwei Yao, William C. Wright, Richard E. Lee, Taosheng Chen, Dinesh M. Fernando, Suresh Dharuman
Publikováno v:
ACS Infect Dis
Increasing rates of drug-resistant Gram-negative (GN) infections, combined with a lack of new GN-effective antibiotic classes, are driving the need for the discovery of new agents. Bacterial metabolism represents an underutilized mechanism of action
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2beef4800bfcf8e9dff91bd728a693b8
https://pubmed.ncbi.nlm.nih.gov/31887254
https://pubmed.ncbi.nlm.nih.gov/31887254
Autor:
Jonathan Low, Brandon Young, Jun J. Yang, John J. Bowling, Zoran Rankovic, Dinesh M. Fernando, Andrew M. Davidoff, Zhenmei Li, Bailey Cooke, Duane G. Currier, Stephen W. White, Jie Fang, Ahmed Abu-Zaid, Julie Maier, Heather Tillman, Zhaohua Lu, Sourav Das, Shivendra V. Singh, Taosheng Chen, Sivaraja Vaithiyalingam, Purva Bulsara, Wenwei Lin, Richard E. Lee, Alaa Altahan, Mi-Kyung Yun, Alireza Abdolvahabi
Histone lysine demethylases (KDMs) are emerging as therapeutic targets in cancer. Development of potent KDM inhibitors may provide additional options for epigenomics-oriented therapies. Using a Time-Resolved Fluorescence Resonance Energy Transfer (TR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c1ac2240ce64466e93c8e36ffb99c2a
Publikováno v:
Canadian Journal of Microbiology. 63:439-449
The alga Cladophora glomerata can erupt in nuisance blooms throughout the lower Great Lakes. Since bacterial abundance increases with the emergence and decay of Cladophora, we investigated the prevalence of antibiotic resistance (ABR) in Cladophora-a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92dbb353ea573b98db0a8fc7cf7770d7
https://doi.org/10.1139/cjm-2016-0803
https://doi.org/10.1139/cjm-2016-0803
Autor:
Leandro Crisostomo, Peter Pelka, Ayush Kumar, Herbert P. Schweizer, P. Malaka De Silva, Kaleigh Ducas-Mowchun, Tzu-Chiao Chao, Dinesh M. Fernando
Publikováno v:
Applied and Environmental Microbiology. 85
The purpose of this study was to create single-copy gene expression systems for use in genomic manipulations of multidrug-resistant (MDR) and extensively drug-resistant (XDR) clinical isolates of Acinetobacter baumannii. In this study, mini-Tn7 vecto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f22cdff1ebf1da399c15e8848f8e4ff
https://doi.org/10.1128/aem.00066-19
https://doi.org/10.1128/aem.00066-19