Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Dinesh K Srinivasan"'
Autor:
Opeolu O Ojo, Dinesh K Srinivasan, Bosede O Owolabi, Srividya Vasu, J Michael Conlon, Peter R Flatt, Yasser H A Abdel-Wahab
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0141549 (2015)
The frog skin host-defense peptide esculentin-2CHa (GFSSIFRGVA10KFASKGLGK D20LAKLGVDLVA30CKISKQC) displays antimicrobial, antitumor, and immunomodulatory properties. This study investigated the antidiabetic actions of the peptide and selected analogu
Externí odkaz:
https://doaj.org/article/94f88058155648b6a4b274e621e49018
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1863:2462-2467
G-protein coupled receptors (GPCRs) are regulated by numerous proteins including kinases, G-proteins, β-arrestins and accessory proteins. Several families of GPCR accessory proteins like Receptor Activity Modifying Proteins, Receptor Transporting Pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2242c05553c4a2ca8c3f083068aade3
https://doi.org/10.1016/j.bbadis.2017.05.008
https://doi.org/10.1016/j.bbadis.2017.05.008
Autor:
Yasser Abdel-Wahab, Mary K. McGahon, Peter R. Flatt, Opeolu O. Ojo, Tim M. Curtis, Dinesh K. Srinivasan, J. Michael Conlon, Bosede O. Owolabi, R. Charlotte Moffett
Publikováno v:
Biological Chemistry. 397:753-764
The frog skin host-defense peptide tigerinin-1R stimulates insulin releasein vitroand improves glucose tolerance and insulin sensitivity in animal models of type 2 diabetes. This study extends these observations by investigating the molecular mechani
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59b0cbd11b4be26197fe8b675f4a0410
https://doi.org/10.1515/hsz-2016-0120
https://doi.org/10.1515/hsz-2016-0120
Autor:
Yasser Abdel-Wahab, Dinesh K. Srinivasan, J. Michael Conlon, Peter R. Flatt, Opeolu O. Ojo, Bosede O. Owolabi
Publikováno v:
Acta Diabetologica. 53:303-315
We have previously described the insulinotropic activities of [I10W]tigerinin-1R (RVCSAIPLPWCH.NH2) in vitro. In this study, we investigated the effects of the peptide on nutrient homoeostasis in mice with diet-induced obesity and insulin resistance.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d84ea7d396b1c2eef6d90287e8c3209
https://doi.org/10.1007/s00592-015-0783-3
https://doi.org/10.1007/s00592-015-0783-3
Publikováno v:
Protein & Peptide Letters. 22:256-263
Earlier peptidomic analysis of the skin secretion of Xenopus amieti led to the identification of orthologs of magainins and other peptides. This study investigated the degradation, in vitro insulin-releasing and acute metabolic effects of magainin-AM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caa7c47604f6a4d54d50e1a7a566ed0b
https://doi.org/10.2174/0929866521666141229105757
https://doi.org/10.2174/0929866521666141229105757
Autor:
Eddie Y. K. Ng, Sourav S. Patnaik, Tejas Canchi, Dinesh K Srinivasan, Ender A. Finol, Sriram Narayanan
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 37
Background: Abdominal Aortic Aneurysms (AAA) have a high risk of mortality if they rupture, making it one of the leading causes of death in elderly men. Hence, a better prediction method is necessary to identify high rupture risk patients. Methods: R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9be5bda8dbb381d3a8d6f7e3003a227a
https://doi.org/10.1161/atvb.37.suppl_1.485
https://doi.org/10.1161/atvb.37.suppl_1.485
Publikováno v:
Biochimie. 95:429-435
Peptidomic analysis of norepinephrine-stimulated skin secretions of the tetraploid clawed frog Xenopus laevis (Pipidae) led to the identification of 10 peptides with the ability to stimulate the release of insulin from the rat BRIN-BD11 clonal β cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f246f01e39c347c6293c7f2731b5cade
https://doi.org/10.1016/j.biochi.2012.10.026
https://doi.org/10.1016/j.biochi.2012.10.026
Autor:
Dinesh K. Srinivasan, Peter R. Flatt, Yasser Abdel-Wahab, J M Conlon, Opeolu O. Ojo, Bosede O. Owolabi
Publikováno v:
Naunyn-Schmiedeberg's archives of pharmacology. 389(7)
The frog skin host-defence peptide hymenochirin-1B has been shown to stimulate insulin release in vitro from isolated pancreatic islets and BRIN-BD11 clonal β-cells. This study examines the effects of 28-day administration of a more potent analogue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e122ce4c4f5d91b671bc75a3973b3bb6
https://pubmed.ncbi.nlm.nih.gov/27068334
https://pubmed.ncbi.nlm.nih.gov/27068334
Autor:
J M Conlon, Peter R. Flatt, Yasser Abdel-Wahab, Dinesh K. Srinivasan, Opeolu O. Ojo, Bosede O. Owolabi
Publikováno v:
European journal of pharmacology. 764
The frog skin host-defense peptide CPF-SE1 has previously been shown to stimulate the in vitro release of insulin from clonal BRIN-BD11 β-cells. In this study, the in vivo effects of the peptide were investigated in male NIH Swiss mice maintained on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cc602801ce8e78b251155ca0181e743
https://pubmed.ncbi.nlm.nih.gov/26123844
https://pubmed.ncbi.nlm.nih.gov/26123844
Autor:
Yasser Abdel-Wahab, Dinesh K. Srinivasan, Peter R. Flatt, Srividya Vasu, J. Michael Conlon, Bosede O. Owolabi, Opeolu O. Ojo
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0141549 (2015)
PLoS ONE
PLoS ONE
The frog skin host-defense peptide esculentin-2CHa (GFSSIFRGVA10KFASKGLGK D20LAKLGVDLVA30CKISKQC) displays antimicrobial, antitumor, and immunomodulatory properties. This study investigated the antidiabetic actions of the peptide and selected analogu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::790c83045c3c647df2bb7a2d48a66604
http://europepmc.org/articles/PMC4626215?pdf=render
http://europepmc.org/articles/PMC4626215?pdf=render