Memantine has a nicotinic neuroprotective pathway in acute hippocampal slices after an NMDA insult

Autor: Yancy Ferrer-Acosta, Sergio Rodriguez-Massó, Dinely Pérez, Vesna A. Eterovic, P.A. Ferchmin, Antonio Henrique Martins

Publikováno v: Toxicology in vitro : an international journal published in association with BIBRA. 84

Memantine is a non-competitive antagonist with a moderate affinity to the N-methyl-d-Aspartate (NMDA) receptor. The present study assessed memantine's neuroprotective activity using electrophysiology of ex-vivo hippocampal slices. Interestingly, a ni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc4960e0050489051ae7d47b430ec079
https://pubmed.ncbi.nlm.nih.gov/35944748

γ-Aminobutyric acid type a receptor inhibition triggers a nicotinic neuroprotective mechanism

Autor: Vesna A. Eterovic, William Castro Alvarez, P.A. Ferchmin, Mario A. Penzo, Dinely Pérez, Héctor M. Maldonado

Publikováno v: Journal of Neuroscience Research. 91:416-425

Nicotinic acetylcholine receptor (nAChR)-mediated neuroprotection has been implicated in the treatment of neurodegenerative disorders such as Alzheimer's and Parkinson's diseases and hypoxic ischemic events as well as other diseases hallmarked by exc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f55dea661fec3aa9bba3856f0fa1c5f
https://doi.org/10.1002/jnr.23155

Tobacco cembranoids protect the function of acute hippocampal slices against NMDA by a mechanism mediated by α4β2 nicotinic receptors

Autor: Jiukuan Hao, Abimael D. Rodriguez, Héctor M. Maldonado, Dinely Pérez, Mario A. Penzo, P.A. Ferchmin, Maria T. Gonzalez, Jean de Vellis

Publikováno v: Journal of Neuroscience Research. 82:631-641

Nicotine has been reported to be neuroprotective in experimental and epidemiological studies. In addition to nicotine, tobacco and cigarette smoke contain cembranoids, which are antagonists of neuronal nicotinic receptors (nAChR). Exposure of hippoca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00446125fa3f1cde9b39b5c69a2be794
https://doi.org/10.1002/jnr.20666

Spermine is neuroprotective against anoxia and N-methyl-d-aspartate in hippocampal slices

Autor: Dinely Pérez, Michelle Biello, P.A. Ferchmin

Publikováno v: Brain Research. 859:273-279

Polyamines were implicated as either neurotoxic or neuroprotective in several models of stroke. Spermine augments the excitotoxicity mediated by the N-methyl-D-aspartate (NMDA) receptor because this receptor is activated at micromolar spermine concen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10d49d63f618be37d7dee7ce9648af14
https://doi.org/10.1016/s0006-8993(00)01973-9

Kinin-B2 receptor mediated neuroprotection after NMDA excitotoxicity is reversed in the presence of Kinin-B1 receptor agonists

Autor: Antonio H. Martins, Henning Ulrich, Pedro A. Ferchmin, Janaina Maria Alves, Dinely Pérez, Marimée Carrasco, Wilmarie Torres-Rivera, Vesna A. Eterovic

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
PLoS ONE
PLoS ONE, Vol 7, Iss 2, p e30755 (2012)

Background Kinins, with bradykinin and des-Arg9-bradykinin being the most important ones, are pro-inflammatory peptides released after tissue injury including stroke. Although the actions of bradykinin are in general well characterized; it remains co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d93c9040c524c33fed6b918a6a915538