Downregulation of the Glial GLT1 Glutamate Transporter and Purkinje Cell Dysfunction in a Mouse Model of Myotonic Dystrophy

Autor: Sicot, G, Servais, L, Dinca, DM, Leroy, A, Prigogine, C, Medja, F, Braz, SO, Huguet-Lachon, A, Chhuon, C, Nicole, A, Gueriba, N, Oliveira, R, Dan, B, Furling, D, Swanson, MS, Guerrera, IC, Cheron, G, Gourdon, G, Gomes-Pereira, M

Publikováno v: Cell reports, 19 (13
Cell Reports
Cell Reports, 2017, 19 (13), pp.2718-2729. ⟨10.1016/j.celrep.2017.06.006⟩
Cell Reports, Vol 19, Iss 13, Pp 2718-2729 (2017)
Cell Reports, Elsevier Inc, 2017, 19 (13), pp.2718-2729. ⟨10.1016/j.celrep.2017.06.006⟩
Cell reports

SUMMARY Brain function is compromised in myotonic dystrophy type 1 (DM1), but the underlying mechanisms are not fully understood. To gain insight into the cellular and molecular pathways primarily affected, we studied a mouse model of DM1 and brains

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::1315bc56a33857c8bdda49e8d6c61b15
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/259739

Downregulation of the Glial GLT1 Glutamate Transporter and Purkinje Cell Dysfunction in a Mouse Model of Myotonic Dystrophy.

Autor: Sicot G; Laboratory CTGDM, Inserm UMR1163, 75015 Paris, France; Institut Imagine, Université Paris Descartes-Sorbonne Paris Cité, 75015 Paris, France., Servais L; Institut I-Motion, Hôpital Armand Trousseau, 75012 Paris, France., Dinca DM; Laboratory CTGDM, Inserm UMR1163, 75015 Paris, France; Institut Imagine, Université Paris Descartes-Sorbonne Paris Cité, 75015 Paris, France., Leroy A; Laboratory of Neurophysiology and Movement Biomechanics, Université Libre de Bruxelles, 1050 Brussels, Belgium; Laboratory of Electrophysiology, University of Mons, 7000 Mons, Belgium., Prigogine C; Laboratory of Neurophysiology and Movement Biomechanics, Université Libre de Bruxelles, 1050 Brussels, Belgium; Laboratory of Electrophysiology, University of Mons, 7000 Mons, Belgium., Medja F; Laboratory CTGDM, Inserm UMR1163, 75015 Paris, France; Institut Imagine, Université Paris Descartes-Sorbonne Paris Cité, 75015 Paris, France., Braz SO; Laboratory CTGDM, Inserm UMR1163, 75015 Paris, France; Institut Imagine, Université Paris Descartes-Sorbonne Paris Cité, 75015 Paris, France., Huguet-Lachon A; Laboratory CTGDM, Inserm UMR1163, 75015 Paris, France; Institut Imagine, Université Paris Descartes-Sorbonne Paris Cité, 75015 Paris, France., Chhuon C; Proteomics Platform 3P5-Necker, Université Paris Descartes-Structure Fédérative de Recherche Necker, Inserm US24/CNRS UMS3633, 75014 Paris, France., Nicole A; Laboratory CTGDM, Inserm UMR1163, 75015 Paris, France; Institut Imagine, Université Paris Descartes-Sorbonne Paris Cité, 75015 Paris, France., Gueriba N; Laboratory CTGDM, Inserm UMR1163, 75015 Paris, France; Institut Imagine, Université Paris Descartes-Sorbonne Paris Cité, 75015 Paris, France., Oliveira R; Department of Molecular Genetics and Microbiology, Center for NeuroGenetics and the Genetics Institute, University of Florida College of Medicine, Gainesville, FL 32610, USA., Dan B; Laboratory of Neurophysiology and Movement Biomechanics, Université Libre de Bruxelles, 1050 Brussels, Belgium; Inkendaal Rehabilitation Hospital, Vlezenbeek B-1602, Belgium., Furling D; Sorbonne Universités UPMC Université Paris 06, Inserm, Centre de Recherche en Myologie UMRS974, Institut de Myologie, Groupe Hospitalier Pitié-Salpêtrière, 75013 Paris, France., Swanson MS; Department of Molecular Genetics and Microbiology, Center for NeuroGenetics and the Genetics Institute, University of Florida College of Medicine, Gainesville, FL 32610, USA., Guerrera IC; Proteomics Platform 3P5-Necker, Université Paris Descartes-Structure Fédérative de Recherche Necker, Inserm US24/CNRS UMS3633, 75014 Paris, France., Cheron G; Laboratory of Neurophysiology and Movement Biomechanics, Université Libre de Bruxelles, 1050 Brussels, Belgium; Laboratory of Electrophysiology, University of Mons, 7000 Mons, Belgium., Gourdon G; Laboratory CTGDM, Inserm UMR1163, 75015 Paris, France; Institut Imagine, Université Paris Descartes-Sorbonne Paris Cité, 75015 Paris, France. Electronic address: genevieve.gourdon@inserm.fr., Gomes-Pereira M; Laboratory CTGDM, Inserm UMR1163, 75015 Paris, France; Institut Imagine, Université Paris Descartes-Sorbonne Paris Cité, 75015 Paris, France. Electronic address: mario.pereira@inserm.fr.

Publikováno v: Cell reports [Cell Rep] 2017 Jun 27; Vol. 19 (13), pp. 2718-2729.