Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Dinara Begimbetova"'
Autor:
Dinara Begimbetova, Agata N. Burska, Aidana Baltabekova, Assiya Kussainova, Assiya Kukanova, Fatima Fazyl, Milana Ibragimova, Kenzhekyz Manekenova, Abay Makishev, Rakhmetkazhi I. Bersimbaev, Dos D. Sarbassov
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 5, p 2531 (2024)
The use of vitamin C (VC) in high doses demonstrates a potent tumor suppressive effect by mediating a glucose-dependent oxidative stress in Kirsten rat sarcoma (KRAS) mutant cancer cells. VC with arsenic trioxide (ATO) is a promising drug combination
Externí odkaz:
https://doaj.org/article/53e3a651510040e4aeb107b49bf48daa
Autor:
Assiya Kussainova, Olga Bulgakova, Akmaral Aripova, Milana Ibragimova, Alessandra Pulliero, Dinara Begimbetova, Rakhmetkazhi Bersimbaev, Alberto Izzotti
Publikováno v:
Journal of Personalized Medicine, Vol 13, Iss 11, p 1599 (2023)
Asbestos is a known carcinogen; however, the influence of chrysotile asbestos on the development of tumor-related diseases remains a subject of intense debate within the scientific community. To analyze the effect of asbestos, we conducted a study us
Externí odkaz:
https://doaj.org/article/293c24a98f474edd88063a220aae894a
Autor:
Alma Zhylkaidarova, Dilyara Kaidarova, Kanat Batyrbekov, Oxana Shatkovskaya, Dinara Begimbetova
Publikováno v:
Clinical Endoscopy, Vol 54, Iss 1, Pp 32-37 (2021)
We carried out an analysis of the total incidence of colon cancer throughout Kazakhstan. Retrospectively, according to the regional reports on endoscopic screening, the study showed an increase in the age-related incidence of colorectal cancer (CRC)
Externí odkaz:
https://doaj.org/article/f5b8ff2e99ce4233a07c02c9112d5f78
Autor:
Agata N. Burska, Bayansulu Ilyassova, Aruzhan Dildabek, Medina Khamijan, Dinara Begimbetova, Ferdinand Molnár, Dos D. Sarbassov
Publikováno v:
Cells, Vol 11, Iss 21, p 3454 (2022)
The turn-on mutations of the KRAS gene, coding a small GTPase coupling growth factor signaling, are contributing to nearly 25% of all human cancers, leading to highly malignant tumors with poor outcomes. Targeting of oncogenic KRAS remains a most cha
Externí odkaz:
https://doaj.org/article/63c40894e1334db2ad76639131414761
Autor:
Yeldar Baiken, Damira Kanayeva, Sabira Taipakova, Regina Groisman, Alexander A. Ishchenko, Dinara Begimbetova, Bakhyt Matkarimov, Murat Saparbaev
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2021)
Chemical alterations in DNA induced by genotoxic factors can have a complex nature such as bulky DNA adducts, interstrand DNA cross-links (ICLs), and clustered DNA lesions (including double-strand breaks, DSB). Complex DNA damage (CDD) has a complex
Externí odkaz:
https://doaj.org/article/fcd12374e7b34765bb48732bcff9f67f
Autor:
Timur Saliev, Dinara Baiskhanova, Dmitriy Beznosko, Dinara Begimbetova, Bauyrzhan Umbayev, Talgat Nurgozhin, Ildar Fakhradiyev, Baimakhan Tanabayev, Dainius Pavalkis
Publikováno v:
Medicina, Vol 56, Iss 12, p 663 (2020)
Background and objectives: The aim of the study was to scrutinize the ability of epsilon-aminocaproic acid (EACA) to prevent radiation-induced damage to human cells. Materials and Methods: Human peripheral blood mononuclear cells (PBMCs) were exposed
Externí odkaz:
https://doaj.org/article/3c0f10607d7b47958e2f0c4750c908c3
Publikováno v:
Central Asian Journal of Global Health, Vol 3, Iss 0 (2014)
Introduction: There are an increasing number of different xenobiotics negatively influencing population health. Therefore, it is important to find effective protectors against mutagenic and toxic effects of environmental pollutants. Naturally occurri
Externí odkaz:
https://doaj.org/article/96e3f9180df64086a213814cddf1b0ea
Publikováno v:
Materials Today: Proceedings. 71:7-12
Autor:
S. K. Abilev, Mariya Suvorova, Dinara Begimbetova, Saule Kolumbayeva, Nuriya Bekmagambetova, A. V. Lovinskaya
Publikováno v:
Acta Ecologica Sinica. 41:499-511
Introduction In this study, physicochemical, genotoxic, and mutagenic properties of water samples from 10 rivers of the Almaty region (Kazakhstan) were evaluated. Results The results of the study demonstrated an increased level of mineralization and
Autor:
Dinara Begimbetova, Assiya Kukanova, Fatima Fazyl, Kenzhekyz Manekenova, Talgat Omarov, Agata N. Burska, Medina Khamijan, Alexandr Gulyayev, Bakytgul Yermekbayeva, Abay Makishev, Timur Saliev, Kanat Batyrbekov, Chokan Aitbayev, Zhanat Spatayev, Dos Sarbassov
Publikováno v:
BioMed research international. 2022
Background. Kirsten rat sarcoma (KRAS) protein is an essential contributor to the development of pancreatic ductal adenocarcinoma (PDAC). KRAS G12D and G12V mutant tumours are significant challenges in cancer therapy due to high resistance to the tre