Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Dinakaran, Murugesan"'
Autor:
Peter C. Ray, Margaret Huggett, Penelope A. Turner, Malcolm Taylor, Laura A. T. Cleghorn, Julie Early, Anuradha Kumar, Shilah A. Bonnett, Lindsay Flint, Douglas Joerss, James Johnson, Aaron Korkegian, Steven Mullen, Abraham L. Moure, Susan H. Davis, Dinakaran Murugesan, Michael Mathieson, Nicola Caldwell, Curtis A. Engelhart, Dirk Schnappinger, Ola Epemolu, Fabio Zuccotto, Jennifer Riley, Paul Scullion, Laste Stojanovski, Lisa Massoudi, Gregory T. Robertson, Anne J. Lenaerts, Gail Freiberg, Dale J. Kempf, Thierry Masquelin, Philip A. Hipskind, Joshua Odingo, Kevin D. Read, Simon R. Green, Paul G. Wyatt, Tanya Parish
Publikováno v:
ACS Omega, Vol 6, Iss 3, Pp 2284-2311 (2021)
Externí odkaz:
https://doaj.org/article/0a27546e2eeb4807bfe33c85491f6518
Autor:
Tanya Parish, Lindsay Flint, Anuradha Kumar, Lisa M. Massoudi, Paul Scullion, Gregory T. Robertson, Shilah A. Bonnett, Simon Green, Nicola Caldwell, Jennifer Riley, Gail M. Freiberg, Philip Arthur Hipskind, Michael Mathieson, Thierry Masquelin, Laste Stojanovski, Curtis A. Engelhart, Margaret Huggett, Dinakaran Murugesan, Abraham Lopez Moure, Fabio Zuccotto, Julie V. Early, Ola Epemolu, Paul G. Wyatt, Dale J. Kempf, Kevin D. Read, Susan Davis, Laura A. T. Cleghorn, James Johnson, Steven Mullen, Malcolm Taylor, Anne J. Lenaerts, Penelope A. Turner, Peter C. Ray, Joshua Odingo, Dirk Schnappinger, Aaron Korkegian, Douglas Joerss
Publikováno v:
ACS Omega
ACS Omega, Vol 6, Iss 3, Pp 2284-2311 (2021)
ACS Omega, Vol 6, Iss 3, Pp 2284-2311 (2021)
With the emergence of multi-drug-resistant strains of Mycobacterium tuberculosis, there is a pressing need for new oral drugs with novel mechanisms of action. A number of scaffolds with potent anti-tubercular in vitro activity have been identified fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::372e1778402b9efb43904bc638481606
http://europepmc.org/articles/PMC7841955
http://europepmc.org/articles/PMC7841955
Autor:
Caroline Wilson, Peter Ray, Fabio Zuccotto, Jorge Hernandez, Anup Aggarwal, Claire Mackenzie, Nicola Caldwell, Malcolm Taylor, Margaret Huggett, Michael Mathieson, Dinakaran Murugesan, Alasdair Smith, Susan Davis, Mattia Cocco, Maloy K. Parai, Arjun Acharya, Fabio Tamaki, Paul Scullion, Ola Epemolu, Jennifer Riley, Laste Stojanovski, Eva Maria Lopez-Román, Pedro Alfonso Torres-Gómez, Ana Maria Toledo, Laura Guijarro-Lopez, Isabel Camino, Curtis A. Engelhart, Dirk Schnappinger, Lisa M. Massoudi, Anne Lenaerts, Gregory T. Robertson, Chris Walpole, David Matthews, David Floyd, James C. Sacchettini, Kevin D. Read, Lourdes Encinas, Robert H. Bates, Simon R. Green, Paul G. Wyatt
Publikováno v:
Journal of Medicinal Chemistry
With increasing drug resistance in tuberculosis (TB) patient populations, there is an urgent need for new drugs. Ideally, new agents should work through novel targets so that they are unencumbered by preexisting clinical resistance to current treatme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5566e8fcf104aad281ff69e40e769633
https://pubmed.ncbi.nlm.nih.gov/34910486
https://pubmed.ncbi.nlm.nih.gov/34910486
Autor:
Sriram, Dharmarajan, Yogeeswari, Perumal, Dinakaran, Murugesan, Banerjee, Debjani, Bhat, Pritesh, Gadhwal, Sunil
Publikováno v:
In European Journal of Medicinal Chemistry 2010 45(1):120-123
Autor:
Senthilkumar, Palaniappan, Dinakaran, Murugesan, Yogeeswari, Perumal, Sriram, Dharmarajan, China, Arnab, Nagaraja, Valakunja
Publikováno v:
In European Journal of Medicinal Chemistry 2009 44(1):345-358
Autor:
Paul G. Wyatt, Peter C. Ray, Kyu Y. Rhee, Sasha L. Lynch, Valerie Mizrahi, Clifton E. Barry, John Post, Helena I. Boshoff, Navid Nahiyaan, Anthony G. Coyne, Tom L. Blundell, Joanna C. Evans, Christina Spry, Dinakaran Murugesan, Vitor Mendes, Simon Green, Jeannine Hess, Stephen Thompson, Chris Abell, Zhe Wang
Publikováno v:
ACS Infectious Diseases
Coenzyme A (CoA) is a ubiquitous cofactor present in all living cells and estimated to be required for up to 9% of intracellular enzymatic reactions. Mycobacterium tuberculosis (Mtb) relies on its own ability to biosynthesize CoA to meet the needs of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b118e20c165cc2ee3aa60e19f743440
https://www.repository.cam.ac.uk/handle/1810/322238
https://www.repository.cam.ac.uk/handle/1810/322238
Autor:
Senthilkumar, Palaniappan, Dinakaran, Murugesan, Banerjee, Debjani, Devakaram, Ruth Vandana, Yogeeswari, Perumal, China, Arnab, Nagaraja, Valakunja, Sriram, Dharmarajan
Publikováno v:
In Bioorganic & Medicinal Chemistry 2008 16(5):2558-2569
Publikováno v:
In Biomedicine & Pharmacotherapy 2008 62(1):1-5
Autor:
Lucy Ellis, Yumi Park, Ola Epemolu, Paul G. Wyatt, Stefano Donini, Laura E. Via, Carolyn Selenski, Matthew Axtman, Thomas R. Ioerger, Menico Rizzi, Tom L. Blundell, Nian Zhou, Simon Green, Olalla Sanz, Maria Osuna-Cabello, David B. Ascher, Helena I. Boshoff, Laste Stojanovski, Travis Hartman, Dale J. Kempf, Clifton E. Barry, Joël Lelièvre, Tracy Bayliss, Zhe Wang, Fred Simeons, Claire J. MacKenzie, Hannah Pflaumer, Valerie Mizrahi, Fabio Zuccotto, James C. Sacchettini, Gracia Santos Diaz, Véronique Dartois, Angela Pacitto, Susan Davis, Kyu Y. Rhee, Laura A. T. Cleghorn, Margaret Huggett, Matthew D. Kurnick, Dinakaran Murugesan, Penelope A. Turner, Kriti Arora, Gerard Drewes, Lluis Ballell, Markus Bösche, Gail M. Freiberg, Kevin D. Read, Surendranadha Reddy Jonnala, Kirsteen I. Buchanan, Maria Jose Lafuente-Monasterio, María José Rebollo-López, Sonja Ghidelli-Disse, Peter C. Ray, Alasdair Smith, Myron Srikumaran, Ardala Breda
Publikováno v:
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
A potent, noncytotoxic indazole sulfonamide was identified by high-throughput screening of >100,000 synthetic compounds for activity against Mycobacterium tuberculosis (Mtb). This noncytotoxic compound did not directly inhibit cell wall biogenesis bu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::896be08dd9046b3b0b9f82d81de880f5
https://doi.org/10.1021/acsinfecdis.6b00103
https://doi.org/10.1021/acsinfecdis.6b00103
Autor:
Karen L. White, Paul G. Wyatt, Suzanne Norval, Marcel Kaiser, Ian H. Gilbert, Clive Yeates, Dinakaran Murugesan, Jennifer Riley, Susan A. Charman, Kevin D. Read
Publikováno v:
Chemmedchem
Previously reported pyrrolones, such as TDR32570, exhibited potential as antimalarial agents; however, while these compounds have potent antimalarial activity, they suffer from poor aqueous solubility and metabolic instability. Here, further structur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1ba3e23e5358e69e8a136a92158c3ac
http://europepmc.org/articles/PMC3963473
http://europepmc.org/articles/PMC3963473