Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Dinah W. Y. Sah"'
Autor:
Wei, Wang, Pengcheng, Zhou, Xin, Wang, Fen, Chen, Emily, Christensen, Jeffrey, Thompson, Xiaoqin, Ren, Adrian, Kells, Lisa, Stanek, Todd, Carter, Jay, Hou, Dinah W Y, Sah
Publikováno v:
Human gene therapy. 33(1-2)
Huntington's disease is a fatal neurodegenerative disorder caused by an inherited mutation in the huntingtin (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bac0214cc396af1a443cbabb55c80d70
https://pubmed.ncbi.nlm.nih.gov/34806402
https://pubmed.ncbi.nlm.nih.gov/34806402
Autor:
Richard Grondin, Pei Ge, Qingmin Chen, Jessica E Sutherland, Zhiming Zhang, Don M Gash, David K Stiles, Gregory R Stewart, Dinah W Y Sah, William F Kaemmerer
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 4, Iss C (2015)
One possible treatment for Huntington's disease involves direct infusion of a small, interfering RNA (siRNA) designed to reduce huntingtin expression into brain tissue from a chronically implanted programmable pump. Here, we studied the suppression o
Externí odkaz:
https://doaj.org/article/2560f36a757e4533913335385c14852e
Autor:
Benjamin E. Deverman, Bernard M. Ravina, Krystof S. Bankiewicz, Steven M. Paul, Dinah W. Y. Sah
Publikováno v:
Nature reviews. Drug discovery. 17(9)
Adeno-associated viral (AAV) vectors are a rapidly emerging gene therapy platform for the treatment of neurological diseases. In preclinical studies, transgenes encoding therapeutic proteins, microRNAs, antibodies or gene-editing machinery have been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e62e452efcbe84b6a01815a4bd4c6383
https://pubmed.ncbi.nlm.nih.gov/30206384
https://pubmed.ncbi.nlm.nih.gov/30206384
Autor:
Michael H. Ossipov, Frank Porreca, Ruizhong Wang, Dinah W. Y. Sah, Anthony Rossomando, Tamara King
Publikováno v:
Pain. 155:476-484
Systemic artemin promotes regeneration of dorsal roots to the spinal cord after crush injury. However, it is unclear whether systemic artemin can also promote peripheral nerve regeneration, and functional recovery after partial lesions distal to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::712f11d67d7121e8fe8e32ba41e5b772
https://doi.org/10.1016/j.pain.2013.11.007
https://doi.org/10.1016/j.pain.2013.11.007
Publikováno v:
Nature Reviews Drug Discovery. 17:767-767
Adeno-associated viral (AAV) vectors are a rapidly emerging gene therapy platform for the treatment of neurological diseases. In preclinical studies, transgenes encoding therapeutic proteins, microRNAs, antibodies or gene-editing machinery have been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e837e8cf3b6b8c551a6e5f6a113cfa1
https://doi.org/10.1038/nrd.2018.158
https://doi.org/10.1038/nrd.2018.158
Autor:
Ruizhong Wang, Frank Porreca, Anthony Rossomando, Eric Frank, Todd W. Vanderah, Michael H. Ossipov, Peter Cariani, Pamela A. Harvey, Tamara King, Dinah W. Y. Sah
Publikováno v:
Nature Neuroscience. 11:488-496
Dorsal root injury results in substantial and often irreversible loss of sensory functions as a result of the limited regenerative capacity of sensory axons and the inhibitory barriers that prevent both axonal entry into and regeneration in the spina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::260f18e1c1f6d95ff3e739396aab4784
https://doi.org/10.1038/nn2069
https://doi.org/10.1038/nn2069
Autor:
C Hession, Melissa Levesque, Zhigang He, John M. Mccoy, Bruce D. Trapp, Jufang Chang, Martin L. Scott, Greg Thill, Xinhua Lee, Svetlane Shulag-Morskaya, Dinah W. Y. Sah, Sha Mi, Zhaohui Shao, Robert H. Miller, Vincent Jung, R. Blake Pepinsky, Mingdi Zhang
Publikováno v:
Nature Neuroscience. 8:745-751
The control of myelination by oligodendrocytes in the CNS is poorly understood. Here we show that LINGO-1 is an important negative regulator of this critical process. LINGO-1 is expressed in oligodendrocytes. Attenuation of its function by dominant-n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc0ec3129a06a231953f1c4ada804fed
https://doi.org/10.1038/nn1460
https://doi.org/10.1038/nn1460
Autor:
Olivia Orozco, Paul Carmillo, Dane S. Worley, Carolyn Buckley, Lee Walus, Richard L. Cate, Carl Rosenblad, Anthony Rossomando, Lone Dagø, Dinah W. Y. Sah, Miller Stephan S, Albert Tse, Eric S. Day, Mette Grønborg, Adrian Whitty
Publikováno v:
Biochemistry. 44:2545-2554
To clarify whether glial cell line-derived neurotrophic factor (GDNF) receptor alpha-1 (GFRalpha1), the glycosylphosphatidylinositol (GPI)-linked coreceptor for GDNF, is also a functional coreceptor for artemin (ART), we have studied receptor binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28bfbe89baa46a494402500af31bc74f
https://doi.org/10.1021/bi049247p
https://doi.org/10.1021/bi049247p
Publikováno v:
Nature Reviews Drug Discovery. 2:460-472
Neuropathic pain is a chronic condition that is caused by injury to the nervous system. Unlike acute pain, which is protective, neuropathic pain persists and serves no useful purpose, and severely affects quality of life. However, present therapies h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2e2ec264bc2d738ed710da5c50f82d8
https://doi.org/10.1038/nrd1107
https://doi.org/10.1038/nrd1107
Publikováno v:
European Journal of Neuroscience. 13:2177-2182
Activation of the RET receptor tyrosine kinase by glial-derived neurotrophic factor family members is dependent on a family of coreceptors, GFRalpha1-4. GFRalpha3 preferentially binds the newest member of the glial-derived neurotrophic factor family
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d9feea1483b77e88d1660edb8359236
https://doi.org/10.1046/j.0953-816x.2001.01596.x
https://doi.org/10.1046/j.0953-816x.2001.01596.x