Zobrazeno 1 - 10 of 19 pro vyhledávání: '"Dina Segal"'
1
A Novel Postpriming Regulatory Check Point of Effector/Memory T Cells Dictated through Antigen Density Threshold-Dependent Anergy
Autor: Denkberg Galit, Oryan Makler, Gideon Rechavi, Ninette Amariglio, Kfir Oved, Yoram Reiter, Hila Novak, Omer Ziv, Chen Gefen-Dor, Sinik Keren, Roy Noy, Dina Segal, Jasmine Jacob-Hirsch
Publikováno v: The Journal of Immunology. 178:2307-2317
CTLs act as the effector arm of the cell-mediated immune system to kill undesirable cells. Two processes regulate these effector cells to prevent self reactivity: a thymic selection process that eliminates autoreactive clones and a multistage activat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3628cc093c279236c1484dd701a1743d
https://doi.org/10.4049/jimmunol.178.4.2307
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2
Antibody-mediated targeting of human single-chain class I MHC with covalently linked peptides induces efficient killing of tumor cells by tumor or viral-specific cytotoxic T lymphocytes
Autor: Kfir Oved, Roy Noy, Avital Lev, Yoram Reiter, Dina Segal
Publikováno v: Cancer Immunology, Immunotherapy. 54:867-879
Soluble forms of human MHC class I HLA-A2 were produced in which the peptide binding groove was uniformly occupied by a single tumor or viral-derived peptides attached via a covalent flexible peptide linker to the N terminus of a single-chain beta-2-
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90a842817879c8987b26c08b16e55823
https://doi.org/10.1007/s00262-005-0666-5
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3
Simultaneous monitoring of binding to and activation of tumor-specific T lymphocytes by peptide–MHC
Autor: Ella Trubniykov, Galit Denkberg, Cyril J. Cohen, Yael S. Schiffenbauer, Yoram Reiter, Dina Segal, Gideon Berke
Publikováno v: Journal of Immunological Methods. 277:39-52
The recent advent of peptide–MHC tetramers has provided a new and effective tool for studying antigen-specific T cell populations through monitoring tetramer binding to T cells by flow cytometry. Yet information regarding T cell activation induced
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afd4a87d7a0da32f63921422ff9f0b74
https://doi.org/10.1016/s0022-1759(03)00110-8
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4
Recruitment of CTL Activity by Tumor-Specific Antibody-Mediated Targeting of Single-Chain Class I MHC-Peptide Complexes
Autor: Dina Segal, Avital Lev, Hila Novak, Yoram Reiter
Publikováno v: The Journal of Immunology. 169:2988-2996
The MHC class I-restricted CD8 CTL effector arm of the adaptive immune response is uniquely equipped to recognize tumor cells as foreign and consequently initiates the cascade of events resulting in their destruction. However, tumors have developed s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55148b37cca31795b07088e39ec2c00f
https://doi.org/10.4049/jimmunol.169.6.2988
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5
Targeting multidrug resistant tumor cells with a recombinant single-chain FV fragment directed to P-glycoprotein
Autor: Esther Pirak, Yoram Reiter, Yehuda G. Assaraf, Revital Niv, Dina Segal
Publikováno v: International Journal of Cancer. 94:864-872
The MDR1 gene product P-glycoprotein (Pgp) plays a key role in multidrug resistance of cancer cells. Pgp is an ATP-driven efflux pump that extrudes a variety of dissimilar hydrophobic cytotoxic compounds. P-glycoprotein overexpression results in mult
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::666cc22176bd292c703efdd7264f57ac
https://doi.org/10.1002/ijc.1552
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6
Recombinant human single-chain MHC-peptide complexes made fromE. coli byin vitro refolding: functional single-chain MHC-peptide complexes and tetramers with tumor associated antigens
Autor: Cyril J. Cohen, Galit Denkberg, Alexei F. Kirkin, Yoram Reiter, Dina Segal
Publikováno v: European Journal of Immunology. 30:3522-3532
Soluble recombinant MHC-peptide complexes are valuable tools for molecular characterization of immune responses as well as for other functional and structural studies. In this study, soluble recombinant single-chain human MHC (scMHC)-peptide complexe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5399eaa80a49491bbfb148b4fd25ddfd
https://doi.org/10.1002/1521-4141(2000012)30:12<3522::aid-immu3522>3.0.co
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7
Selective antibody-mediated targeting of class I MHC to EGFR-expressing tumor cells induces potent antitumor CTL activity in vitro and in vivo
Autor: Dina Segal, Winfried S. Wels, Kfir Oved, Yoram Reiter, Hila Novak, Roy Noy
Publikováno v: International journal of cancer. 120(2)
Epidermal growth factor receptor (EGFR) is highly overexpressed in many tumor types. We present a new fusion molecule that can target solid tumors that express EGFR. The fusion molecule combines the advantage(s) of the well-established tumor targetin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ada199e094fc5998514af5d5e2bbdaa7
https://pubmed.ncbi.nlm.nih.gov/17066453
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9
Tumor-specific Ab-mediated targeting of MHC-peptide complexes induces regression of human tumor xenografts in vivo
Autor: Roy Noy, Avital Lev, Peter Walden, Yoram Reiter, Dina Segal, Dietmar Zehn, Hila Novak, Kfir Oved
Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 101(24)
A cancer immunotherapy strategy is described herein that combines the advantage of the well established tumor targeting capabilities of high-affinity recombinant fragments of Abs with the known efficient, specific, and potent killing ability of CD8 T
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e13d89aaea641feee6983071ee6385b
https://pubmed.ncbi.nlm.nih.gov/15184663
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