Výsledky vyhledávání - "Dina S. Coelho"

Akademický článek

Neuronal Selection Based on Relative Fitness Comparison Detects and Eliminates Amyloid-β-Induced Hyperactive Neurons in Drosophila

Autor: Dina S. Coelho, Eduardo Moreno

Publikováno v: iScience, Vol 23, Iss 9, Pp 101468- (2020)

Summary: During adult life, damaged but viable neurons can accumulate in the organism, creating increasingly heterogeneous and dysfunctional neural circuits. One intriguing example is the aberrant increased activity of cerebral networks detected in v

Externí odkaz: https://doaj.org/article/e6449cde8efc4ee89915e4b2df8e8172

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Akademický článek

Culling Less Fit Neurons Protects against Amyloid-β-Induced Brain Damage and Cognitive and Motor Decline

Autor: Dina S. Coelho, Silvia Schwartz, Marisa M. Merino, Barbara Hauert, Barbara Topfel, Colin Tieche, Christa Rhiner, Eduardo Moreno

Publikováno v: Cell Reports, Vol 25, Iss 13, Pp 3661-3673.e3 (2018)

Summary: Alzheimer’s disease (AD) is the most common form of dementia, impairing cognitive and motor functions. One of the pathological hallmarks of AD is neuronal loss, which is not reflected in mouse models of AD. Therefore, the role of neuronal

Externí odkaz: https://doaj.org/article/b10a33798f2f4a09a09739163318337c

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Akademický článek

Xbp1-Independent Ire1 Signaling Is Required for Photoreceptor Differentiation and Rhabdomere Morphogenesis in Drosophila

Autor: Dina S. Coelho, Fatima Cairrão, Xiaomei Zeng, Elisabete Pires, Ana V. Coelho, David Ron, Hyung Don Ryoo, Pedro M. Domingos

Publikováno v: Cell Reports, Vol 5, Iss 3, Pp 791-801 (2013)

The unfolded protein response (UPR) is composed by homeostatic signaling pathways that are activated by excessive protein misfolding in the endoplasmic reticulum. Ire1 signaling is an important mediator of the UPR, leading to the activation of the tr

Externí odkaz: https://doaj.org/article/2bda0850cba34dba81f767692c7e0b31

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Akademický článek

Physiological roles of Regulated Ire1 Dependent Decay

Autor: Dina S. Coelho, Pedro M. Domingos

Publikováno v: Frontiers in Genetics, Vol 5 (2014)

Ire1 is an important transducer of the Unfolded Protein Response (UPR) that is activated by the accumulation of misfolded proteins in the Endoplamic Reticulum (ER stress). Activated Ire1 mediates the splicing of an intron from the mRNA of Xbp1, causi

Externí odkaz: https://doaj.org/article/0048dc28ed204dd68decc5aff2653154

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Emerging links between cell competition and Alzheimer's disease

Autor: Eduardo Moreno, Dina S. Coelho

Publikováno v: Journal of cell science. 132(13)

Alzheimer's disease (AD) causes a progressive loss of memory and other cognitive functions, which inexorably debilitates patients. There is still no cure for AD and effective treatments to delay or revert AD are urgently needed. On a molecular level,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c5e816cfe80bfa2cb6a1191f640b16c
https://pubmed.ncbi.nlm.nih.gov/31263078

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Culling Less Fit Neurons Protects against Amyloid-β-Induced Brain Damage and Cognitive and Motor Decline

Autor: Christa Rhiner, Marisa M. Merino, Colin Tièche, Silvia Schwartz, Barbara Hauert, Dina S. Coelho, Eduardo Moreno, Barbara Topfel

Publikováno v: Cell Reports
Cell Reports, Vol 25, Iss 13, Pp 3661-3673.e3 (2018)

Summary Alzheimer’s disease (AD) is the most common form of dementia, impairing cognitive and motor functions. One of the pathological hallmarks of AD is neuronal loss, which is not reflected in mouse models of AD. Therefore, the role of neuronal d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50047fee04c3228005d67ba6d79fed7e
https://pubmed.ncbi.nlm.nih.gov/30590040

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Xbp1-Independent Ire1 Signaling Is Required for Photoreceptor Differentiation and Rhabdomere Morphogenesis in Drosophila

Autor: David Ron, Pedro Domingos, Fátima Cairrão, Ana Varela Coelho, Dina S. Coelho, Xiaomei Zeng, Elisabete Pires, Hyung Don Ryoo

Publikováno v: Cell Reports, Vol 5, Iss 3, Pp 791-801 (2013)

The Unfolded Protein Response (UPR) is composed by homeostatic signaling pathways that are activated by excessive protein misfolding in the endoplasmic reticulum (ER). Ire1 signaling is an important mediator of the UPR, leading to the activation of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f85cb3722f2edadb662028104856c074
http://www.sciencedirect.com/science/article/pii/S221112471300569X

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Physiological roles of regulated Ire1 dependent decay

Autor: Pedro Domingos, Dina S. Coelho

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Frontiers in Genetics
Frontiers in Genetics, Vol 5 (2014)

Inositol-requiring enzyme 1 (Ire1) is an important transducer of the unfolded protein response (UPR) that is activated by the accumulation of misfolded proteins in the endoplamic reticulum (ER stress). Activated Ire1 mediates the splicing of an intro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35ff45d9481268c633492c097e646009
https://hdl.handle.net/10362/92267

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Akademický článek

Ire1 mediated mRNA splicing in a C-terminus deletion mutant of Drosophila Xbp1.

Autor: Dina S Coelho, Catarina J Gaspar, Pedro M Domingos

Publikováno v: PLoS ONE, Vol 9, Iss 8, p e105588 (2014)

The Unfolded Protein Response is a homeostatic mechanism that permits eukaryotic cells to cope with Endoplasmic Reticulum (ER) stress caused by excessive accumulation of misfolded proteins in the ER lumen. The more conserved branch of the UPR relies

Externí odkaz: https://doaj.org/article/81b0aa3b9fa14533a2e7f45b06e190bb

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