Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Dina Michael"'
Double-stranded DNA (dsDNA) in the cytoplasm of eukaryotic cells is abnormal and typically indicates the presence of pathogens or mislocalized self-DNA. Multiple sensors detect cytosolic dsDNA and trigger robust immune responses via activation of typ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::468a4cc33f899e5473188125e628ec64
https://doi.org/10.21203/rs.3.rs-2264736/v1
https://doi.org/10.21203/rs.3.rs-2264736/v1
Autor:
Jihyun G. Kim, Jocelyn V. Peña, Hannah P. McQueen, Lingwei Kong, Dina Michael, Pamela R. Cook
Cancer immunotherapy holds great promise for the treatment of solid tumors, but its effectiveness is hindered by the recruitment of regulatory T cells (Tregs), which inhibit anti-tumor immune responses. We report here that cytosolic dsDNA, a characte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b4706aae528225e0e41c5763f9c519de
https://doi.org/10.1101/2022.03.08.483519
https://doi.org/10.1101/2022.03.08.483519
Autor:
Georgette Castanedo, Shirley A. Brunton, Susan Wong, James C. Marsters, Lesley J. Murray, Laurent Salphati, Karen Kotkow, Cyrus Khojasteh, Kevin Lau, Stanley Mark S, Michael F. T. Koehler, Dina Michael S, Lee L. Rubin, Wei Jia, Hank La, Daniel P. Sutherlin, Leslie Lee, Shumei Wang, Jason Halladay, Changgeng Qian, John H. A. Stibbard, Savita Ubhayaker, Janet L. Gunzner, Kirk Robarge, Stephen E. Gould, Oivin Guichert, Minli Xie, Lalonde Rebecca, Richard Goldsmith, Yong Cui, Derek Marshall
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:5576-5581
SAR for a wide variety of heterocyclic replacements for a benzimidazole led to the discovery of functionalized 2-pyridyl amides as novel inhibitors of the hedgehog pathway. The 2-pyridyl amides were optimized for potency, PK, and drug-like properties
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e862c173e6b7fb83ca5bda975f9f516c
https://doi.org/10.1016/j.bmcl.2009.08.049
https://doi.org/10.1016/j.bmcl.2009.08.049
Autor:
Robarge, Kirk D. a, ⁎, Brunton, Shirley A. b, Castanedo, Georgette M. a, Cui, Yong a, Dina, Michael S. a, Goldsmith, Richard a, Gould, Stephen E. c, Guichert, Oivin c, Gunzner, Janet L. a, Halladay, Jason a, Jia, Wei a, Khojasteh, Cyrus a, Koehler, Michael F.T. a, Kotkow, Karen c, La, Hank a, LaLonde, Rebecca L. a, Lau, Kevin a, Lee, Leslie a, Marshall, Derek a, Marsters, James C., Jr. a, Murray, Lesley J. a, Qian, Changgeng c, Rubin, Lee L. c, Salphati, Laurent a, Stanley, Mark S. a, Stibbard, John H.A. b, Sutherlin, Daniel P. a, Ubhayaker, Savita a, Wang, Shumei a, Wong, Susan a, Xie, Minli a
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 2009 19(19):5576-5581
Autor:
Rob Webb, Kirk Robarge, Dina Michael S, Weese Kenneth J, Alan G. Olivero, Todd C. Somers, Brent Blackburn, Ignacio Aliagas, Maureen H. Tischler, Thomas E. Rawson, Arthur Lee
Publikováno v:
Bioorganicmedicinal chemistry. 6(12)
Antagonists of the glycoprotein GPIIb/IIIa are a promising class of antithrombotic agents offering potential advantages over present antiplatelet agents (i.e., aspirin and ticlopidine). Novel tricyclic nonpeptidal GPIIb/IIIa antagonists have been pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d45ae6584c9f7e0e891f8921d9b3f479
https://pubmed.ncbi.nlm.nih.gov/9925295
https://pubmed.ncbi.nlm.nih.gov/9925295
Autor:
Janet L. Gunzner, Dina Michael S, Laurent Salphati, Karen Kotkow, James C. Marsters, Richard Goldsmith, Lesley J. Murray, Yong Cui, Hank La, Wei Jia, Jason Halladay, Kirk Robarge, Daniel P. Sutherlin, Lalonde Rebecca, Derek Marshall, Savita Ubhayaker, Shirley A. Brunton, Changgeng Qian, John H. A. Stibbard, Georgette Castanedo, Susan Wong, Leslie Lee, Cyrus Khojasteh, Lee L. Rubin, Shumei Wang, Stanley Mark S, Michael F. T. Koehler, Kevin Lau, Stephen E. Gould, Oivin Guichert, Minli Xie
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:771
Kirk D. Robarge *, Shirley A. Brunton , Georgette M. Castanedo , Yong Cui , Michael S. Dina , Richard Goldsmith , Stephen E. Gould , Oivin Guichert , Janet L. Gunzner , Jason Halladay , Wei Jia , Cyrus Khojasteh , Michael F. T. Koehler , Karen Kotkow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6abc5f52cbbd6cce8c4952ab00ea8953
https://doi.org/10.1016/j.bmcl.2009.11.129
https://doi.org/10.1016/j.bmcl.2009.11.129
Autor:
Robarge, Kirk D. a, ⁎, Brunton, Shirley A. b, Castanedo, Georgette M. a, Cui, Yong a, Dina, Michael S. a, Goldsmith, Richard a, Gould, Stephen E. c, Guichert, Oivin c, Gunzner, Janet L. a, Halladay, Jason a, Jia, Wei a, Khojasteh, Cyrus a, Koehler, Michael F.T. a, Kotkow, Karen c, La, Hank a, LaLonde, Rebecca L. a, Lau, Kevin a, Lee, Leslie a, Marshall, Derek a, Marsters, James C., Jr. a, Murray, Lesley J. a, Qian, Changgeng c, Rubin, Lee L. c, Salphati, Laurent a, Stanley, Mark S. a, Stibbard, John H.A. b, Sutherlin, Daniel P. a, Ubhayaker, Savita a, Wang, Shumei a, Wong, Susan a, Xie, Minli a
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 2010 20(2):771-771
Autor:
Robarge, Kirk D., Dina, Michael S., Somers, Todd C., Lee, Arthur, Rawson, Thomas E., Olivero, Alan G., Tischler, Maureen H., Webb, Robert R., Weese, Kenneth J., Aliagas, Ignacio, Blackburn, Brent K.
Publikováno v:
Bioorganic & Medicinal Chemistry; 1998, Vol. 6 Issue: 12 p2345-2381, 37p
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Akademický článek
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