Výsledky vyhledávání - "Dina M. El-Guindy"

Akademický článek

Immunohistochemical based molecular subtypes of muscle-invasive bladder cancer: association with HER2 and EGFR alterations, neoadjuvant chemotherapy response and survival

Autor: Duaa S. Helal, Sara A. Darwish, Radwa A. Awad, Dina A. Ali, Dina M. El-Guindy

Publikováno v: Diagnostic Pathology, Vol 18, Iss 1, Pp 1-13 (2023)

Abstract Muscle-invasive bladder cancers (MIBCs) is a group of molecularly heterogonous diseases that could be stratified into subtypes with distinct clinical courses and sensitivities to chemotherapy. Clinical application of molecular subtypes could

Externí odkaz: https://doaj.org/article/66bcad80921f4bd6adb1049c3b1e8d0e

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Akademický článek

Pathologic assessment of tumor-associated macrophages and their histologic localization in invasive breast carcinoma

Autor: Shorouk E. Mwafy, Dina M. El-Guindy

Publikováno v: Journal of the Egyptian National Cancer Institute, Vol 32, Iss 1, Pp 1-11 (2020)

Abstract Background Tumor-associated macrophages (TAMs) are important in regulating cross-talk between tumor cells and tumor microenvironment. TAMs are involved in multiple steps of tumor progression and invasion. This study aimed to compare CD163 ex

Externí odkaz: https://doaj.org/article/da54c26ffd804a17b90689825b169e6c

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Akademický článek

Oct4 expression in gastric carcinoma: association with tumor proliferation, angiogenesis and survival

Autor: Dina M. El-Guindy, Rania E. Wasfy, Muhammad T. Abdel Ghafar, Dina A. Ali, Asmaa M. Elkady

Publikováno v: Journal of the Egyptian National Cancer Institute, Vol 31, Iss 1, Pp 1-11 (2019)

Abstract Background Octamer-binding transcription factor 4 (Oct4) is a transcription factor that has an important role in stem cell differentiation and self-renewal. Oct4 has also been implicated in tumorigenicity of different cancers. This study aim

Externí odkaz: https://doaj.org/article/6661e2688f054dafbfae7e17c66f77c7

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Akademický článek

Programmed cell death ligand-1 (PD-L1) expression combined with CD8 tumor infiltrating lymphocytes density in non-small cell lung cancer patients

Autor: Dina M. El-Guindy, Duaa S. Helal, Nesreen M. Sabry, Mohamed Abo El-Nasr

Publikováno v: Journal of the Egyptian National Cancer Institute, Vol 30, Iss 4, Pp 125-131 (2018)

Cancer immunotherapy targeting programmed cell death-1/programmed cell death ligand-1 (PD-1/PD-L1) pathway has shown promising results in treatment of non-small cell lung cancer (NSCLC) patients. T cells play a major role in tumor-associated immune r

Externí odkaz: https://doaj.org/article/ed02ce4314854555bb050bf1bfc6dc68

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Akademický článek

Maspin expression and subcellular localization in invasive ductal carcinoma of the breast: Prognostic significance and relation to microvessel density

Autor: Duaa S. Helal, Dina M. El-Guindy

Publikováno v: Journal of the Egyptian National Cancer Institute, Vol 29, Iss 4, Pp 177-183 (2017)

Maspin (Mammary serine protease inhibitor) is a tumor suppressor serine. Its clinical significance and role in breast carcinoma are contradictory and inconclusive. Researches demonstrated that the function of maspin differs according to its subcellul

Externí odkaz: https://doaj.org/article/aef860ede71f4da58e58e1c7e1d20543

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Akademický článek

The Prognostic Significance of MACC1 Expression in Breast Cancer and Its Relationship to Immune Cells in the Tumor Microenvironment and Patient Survival

Autor: Dina A. Ali, Dina M. El-Guindy, Mohamed A. Elrashidy, Nesreen M. Sabry, Ahmed M. Kabel, Rasha A. Gaber, Rowida R. Ibrahim, Sara M. Samy, Marwa M. Shalaby, Samir A. Salama, Dina Abdelhai

Publikováno v: Medicina, Vol 57, Iss 9, p 934 (2021)

Breast cancer (BC) is one of the most prevalent malignancies among females worldwide. Globally, distant metastases were reported to be responsible for a large proportion of breast cancer-related deaths. The metastasis-associated colon cancer-1 (MACC1

Externí odkaz: https://doaj.org/article/bab9413b96fc47f6970528e3a19b691a

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Hypoxia-induced autophagy in triple negative breast cancer: association with prognostic variables, patients’ survival and response to neoadjuvant chemotherapy

Autor: Dina M. El-Guindy, Fatma MKh Ibrahim, Dina A. Ali, Hemat El-Sayed El-Horany, Nesreen M. Sabry, Rasha A. Elkholy, Wael Mansour, Duaa S. Helal

Publikováno v: Virchows Archiv. 482:823-837

Autophagy is a cellular response to diverse stresses within tumor microenvironment (TME) such as hypoxia. It enhances cell survival and triggers resistance to therapy. This study investigated the prognostic importance of HIF-1α and miR-210 in triple

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a45bc71a7940a1a5212336c70eb78faa
https://doi.org/10.1007/s00428-023-03527-4

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Potential role of tumor‐associated macrophages and CD163 / CD68 ratio in mycosis fungoides and Sézary syndrome in correlation with serum sCD163 and CCL22

Autor: Lamia H Elgarhy, Dina Adam Ali, Duaa S. Helal, Rasha A Elkholy, Dina M. El-Guindy

Publikováno v: Journal of Cutaneous Pathology. 49:261-273

Currently, there are no curative treatment options for mycosis fungoides (MF) and Sezary syndrome (SS) other than stem cell transplant. Understanding the interplay between tumor cells and tumor microenvironment could aid in the development of new the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::53615c6a4fff6488042ed8c1169d60db
https://doi.org/10.1111/cup.14155

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