Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Dina Laznik-Bogoslavski"'
Autor:
Gina Z. Lu, Mark P. Jedrychowski, Vadim N. Gladyshev, Lawrence Kazak, Steven P. Gygi, John Szpyt, Ryan Garrity, Marco Mariotti, Dina Laznik-Bogoslavski, Bruce M. Spiegelman, Michael P. Murphy, Edward T. Chouchani, Joao A. Paulo, Devin K. Schweppe
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Oxidation of cysteines by reactive oxygen species (ROS) initiates thermogenesis in brown and beige adipose tissues. Cellular selenols, where selenium replaces sulfur, exhibit enhanced reactivity with ROS. Here we developed a mass spectro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f164887ab4f31a3f6cf56d55d782b09
https://doi.org/10.1073/pnas.2001387117
https://doi.org/10.1073/pnas.2001387117
Autor:
Haopeng Xiao, Luiz H.M. Bozi, Yizhi Sun, Christopher L. Riley, Vivek M. Philip, Mandy Chen, Jiaming Li, Tian Zhang, Evanna L. Mills, Margo P. Emont, Wenfei Sun, Anita Reddy, Ryan Garrity, Jiani Long, Tobias Becher, Laura Potano Vitas, Dina Laznik-Bogoslavski, Martha Ordonez, Xinyue Liu, Xiong Chen, Yun Wang, Weihai Liu, Nhien Tran, Yitong Liu, Yang Zhang, Aaron M. Cypess, Andrew P. White, Yuchen He, Rebecca Deng, Heiko Schöder, Joao A. Paulo, Mark P. Jedrychowski, Alexander S. Banks, Yu-Hua Tseng, Paul Cohen, Linus T. Tsai, Evan D. Rosen, Samuel Klein, Maria Chondronikola, Fiona E. McAllister, Nick Van Bruggen, Edward L. Huttlin, Bruce M. Spiegelman, Gary A. Churchill, Steven P. Gygi, Edward T. Chouchani
Publikováno v:
Cell. 185:4654-4673.e28
Brown adipose tissue (BAT) regulates metabolic physiology. However, nearly all mechanistic studies of BAT protein function occur in a single inbred mouse strain, which has limited the understanding of generalizable mechanisms of BAT regulation over p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::748551ec42a3be7a69d4b8e61052022c
https://doi.org/10.1016/j.cell.2022.10.003
https://doi.org/10.1016/j.cell.2022.10.003
Autor:
John Szpyt, Bruce M. Spiegelman, Steven P. Gygi, Haopeng Xiao, Michael P. Murphy, Nhien Tran, Ryan Garrity, Evanna L. Mills, Anja V. Gruszczyk, Cathal Harmon, Gary A. Bradshaw, Edward T. Chouchani, Lydia Lynch, Hannah Prendeville, Mark P. Jedrychowski, Dina Laznik-Bogoslavski
Publikováno v:
Cell Metab
Summary Uncoupling protein 1 (UCP1) is a major regulator of brown and beige adipocyte energy expenditure and metabolic homeostasis. However, the widely employed UCP1 loss-of-function model has recently been shown to have a severe deficiency in the en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fdb71b25e4f336f6c2fb959e4865721
https://doi.org/10.1016/j.cmet.2021.11.003
https://doi.org/10.1016/j.cmet.2021.11.003
Autor:
Alexander S. Banks, Jang Hyun Choi, James C. Lo, Lawrence Kazak, Melin J. Khandekar, James P. White, Dina Laznik-Bogoslavski, Theodore M. Kamenecka, Kwok-Kin Wong, Bruce M. Spiegelman, Paul Cohen, Patrick R. Griffin
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 115(3)
The peroxisome-proliferator receptor-γ (PPARγ) is expressed in multiple cancer types. Recently, our group has shown that PPARγ is phosphorylated on serine 273 (S273), which selectively modulates the transcriptional program controlled by this prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a80acb39f78b33baa24b98f861e02f48
https://pubmed.ncbi.nlm.nih.gov/29295932
https://pubmed.ncbi.nlm.nih.gov/29295932
Autor:
Shingo Kajimura, Lawrence Kazak, Dina Laznik-Bogoslavski, Bruce M. Spiegelman, Paul Cohen, Mark P. Jedrychowski, Sebastian C. Hasenfuss, Ramalingam Vetrivelan, Kosaku Shinoda, Edward T. Chouchani, Steve P. Gygi, Brian K. Erickson, Gina Z. Lu
Publikováno v:
Cell. 163:643-655
SummaryThermogenic brown and beige adipose tissues dissipate chemical energy as heat, and their thermogenic activities can combat obesity and diabetes. Herein the functional adaptations to cold of brown and beige adipose depots are examined using qua
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2efd3ee589de5a4275cf6e24f428eb4
https://doi.org/10.1016/j.cell.2015.09.035
https://doi.org/10.1016/j.cell.2015.09.035
Autor:
Jun Wu, Bruce M. Spiegelman, Dina Laznik-Bogoslavski, Michael E. Greenberg, Di Ma, Jiandie D. Lin, John Salogiannnis, James P. White, Christiane D. Wrann
Publikováno v:
Cell Metabolism. 18(5):649-659
Summary Exercise can improve cognitive function and has been linked to the increased expression of brain-derived neurotrophic factor (BDNF). However, the underlying molecular mechanisms driving the elevation of this neurotrophin remain unknown. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7a469eee783b57e3082967b8079a9aa
Autor:
Alan J. Robinson, Mark P. Jedrychowski, John Szpyt, Ramalingam Vetrivelan, Brian K. Erickson, Gina Z. Lu, Bruce M. Spiegelman, Kerry A. Pierce, Clary B. Clish, Lawrence Kazak, Dina Laznik-Bogoslavski, Edward T. Chouchani, Steve P. Gygi
Publikováno v:
Nature
Brown and beige adipose tissues can dissipate chemical energy as heat through thermogenic respiration, which requires uncoupling protein 1 (UCP1). Thermogenesis from these adipocytes can combat obesity and diabetes, encouraging investigation of facto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca868aa46d85258a9b6fa18d016a677d
https://pubmed.ncbi.nlm.nih.gov/27281219
https://pubmed.ncbi.nlm.nih.gov/27281219
Autor:
Ivan Vuckovic, Edward T. Chouchani, Amir I. Mina, Gina Z. Lu, Song Zhang, Mark P. Jedrychowski, Manju Kumari, Alexander S. Banks, Lawrence Kazak, Petras P. Dzeja, Evan D. Rosen, Dina Laznik-Bogoslavski, Bruce M. Spiegelman, Curtis J. Bare
Publikováno v:
Cell Metabolism. 26:693
Summary Diet-induced thermogenesis is an important homeostatic mechanism that limits weight gain in response to caloric excess and contributes to the relative stability of body weight in most individuals. We previously demonstrated that creatine enha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36800debb2eb4588a98a7d972fd84b0e
https://doi.org/10.1016/j.cmet.2017.09.007
https://doi.org/10.1016/j.cmet.2017.09.007
Autor:
Peter-James H. Zushin, Dina Laznik-Bogoslavski, Fiona E. McAllister, Gerald I. Shulman, Michael J. Jurczak, Joao Paulo Camporez, Alexander S. Banks, Bruce M. Spiegelman, Steven P. Gygi
Publikováno v:
Nature
Blocking ERK/MAP kinases improves insulin sensitivity thorough a mechanism similar to the actions of the anti-diabetic thiazolidinediones drugs on PPARγ. The nuclear receptor PPARγ is required for glucose metabolism and is a drug target in diabetes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7991dd1b282b1a930b2d3073ca28a33
https://pubmed.ncbi.nlm.nih.gov/25409143
https://pubmed.ncbi.nlm.nih.gov/25409143
Autor:
Lawrence Kazak, Bruce M. Spiegelman, Brian K. Erickson, Kerry A. Pierce, Mark P. Jedrychowski, Gina Z. Lu, Dina Laznik-Bogoslavski, Edward T. Chouchani, Ramalingam Vetrivelan, John Szpyt, Steve P. Gygi, Alan J. Robinson, Clary B. Clish
Publikováno v:
Nature. 536:360-360
Nature 532, 112–116 (2016); doi:10.1038/nature17399 In this Letter, owing to a typographical error, Fig. 4h was erroneously referred to as Fig. 4j in the text and in the Fig. 4 legend. This error has been corrected online.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53e5d72e964eefc8fcaf99d21f7e39d0
https://doi.org/10.1038/nature18279
https://doi.org/10.1038/nature18279