Výsledky vyhledávání - "Dina I.A. Othman"

Akademický článek

Synthesis of novel spirochromane incorporating Schiff's bases, potential antiproliferative activity, and dual EGFR/HER2 inhibition: Cell cycle analysis and in silico study

Autor: Dina I.A. Othman, Abdelrahman Hamdi, Walaa M. Elhusseiny, Adel S. El-Azab, Ahmed H. Bakheit, Mohamed Hefnawy, Alaa A.-M. Abdel-Aziz

Publikováno v: Saudi Pharmaceutical Journal, Vol 31, Iss 11, Pp 101803- (2023)

Spirochromanes incorporating Schiff's bases and semicarbazones 4a-e and 5a-j were synthesizedand analyzed for their potential antiproliferative activity using four human cancer cell lines (MCF-7, HCT-116, PC3, and A549). Compounds 5a, 5b and 5g posse

Externí odkaz: https://doaj.org/article/4e5c3903315b4d37ba6fe518806d11e8

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Novel diaryl ether derivatives as InhA inhibitors: Design, synthesis and antimycobacterial activity

Autor: Ola A. Abdelaziz, Dina I.A. Othman, Marwa M. Abdel-Aziz, Sahar M.I. Badr, Hassan M. Eisa

Publikováno v: Bioorganic chemistry. 129

A new series of triclosan (TCL)-mimicking diaryl ether derivatives 7-25 were synthesized and evaluated as inhibitors of enoyl acyl carrier protein reductase InhA enzyme. In addition, these derivatives were screened as inhibitors of drug-susceptible (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3761d2b0da4dbc658892a00c4b0dec8d
https://pubmed.ncbi.nlm.nih.gov/36126606

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Novel 2-arylthiazolidin-4-one-thiazole hybrids with potent activity against Mycobacterium tuberculosis

Autor: Dina I.A. Othman, Abdelrahman Hamdi, Marwa M. Abdel-Aziz, Sherin M. Elfeky

Publikováno v: Bioorganic chemistry. 124

Substituted aldehydes, ethyl 2-(2-amino-thiazol-4-yl)acetate), and 2-mercaptoacetic acid, in a three-component one-pot green synthetic approach afforded 2-arylthiazolidin-4-one- thiazole hybrids(T1-T13). Compounds showed good anti-tubercular activity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea1eb3b92b1c46c4c0e2cc3a050e036a
https://pubmed.ncbi.nlm.nih.gov/35447406

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Synthesis, antitumor, and apoptosis-inducing activities of novel 5-arylidenethiazolidine-2,4-dione derivatives: Histone deacetylases inhibitory activity and molecular docking study

Autor: Abdelrahman Hamdi, Walaa M. Elhusseiny, Dina I.A. Othman, Abdullah Haikal, Ahmed H. Bakheit, Adel S. El-Azab, Mohamed H.M. Al-Agamy, Alaa A.-M. Abdel-Aziz

Publikováno v: European Journal of Medicinal Chemistry. 244:114827

The antitumor activity of the newly synthesized 5-arylidenethiazolidine-2,4-dione derivatives 18a-f and 19a-f was investigated, compared to doxorubicin (IC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::537c6a78be43367d886ec38f0d385531
https://doi.org/10.1016/j.ejmech.2022.114827

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Design, synthesis, antitumor, and VEGFR-2 inhibition activities of novel 4-anilino-2-vinyl-quinazolines: Molecular modeling studies

Autor: Abdelrahman Hamdi, Hamed W. El-Shafey, Dina I.A. Othman, Adel S. El-Azab, Nawaf A. AlSaif, Alaa A.-M. Abdel-Aziz

Publikováno v: Bioorganic Chemistry. 122:105710

The antitumor activity of newly synthesized 4-anilino-2-vinylquinazolines 8a-r was measured comparable to sorafenib as a standard drug. The 2-vinylquinazolines 8a-r were evaluated for their in vitro antitumor activity. The most active antitumor agent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2df31971256a638160cb19027dd6adb4
https://doi.org/10.1016/j.bioorg.2022.105710

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