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pro vyhledávání: '"Dina G Hassan"'
Autor:
Shashank Dadsena, Svenja Bockelmann, John G. M. Mina, Dina G. Hassan, Sergei Korneev, Guilherme Razzera, Helene Jahn, Patrick Niekamp, Dagmar Müller, Markus Schneider, Fikadu G. Tafesse, Siewert J. Marrink, Manuel N. Melo, Joost C. M. Holthuis
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Ceramides are lipids that act directly on mitochondria to trigger apoptosis, but the underlying mechanism remains largely unclear. Here authors use a photoactivatable ceramide probe combined with a computation approach and functional studies to ident
Externí odkaz:
https://doaj.org/article/161032635f8246f6afb463a1fd58d74b
Autor:
Svenja Bockelmann, JohnG.M. Mina, Sergei Korneev, Dina G. Hassan, Dagmar Müller, Angelika Hilderink, Hedwich C. Vlieg, Reinout Raijmakers, AlbertJ.R. Heck, Per Haberkant, JoostC.M. Holthuis
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 3, Pp 515-530 (2018)
Ceramides are central intermediates of sphingolipid metabolism with dual roles as mediators of cellular stress signaling and mitochondrial apoptosis. How ceramides exert their cytotoxic effects is unclear and their poor solubility in water hampers a
Externí odkaz:
https://doaj.org/article/5fbde1ea7ab742f59e3b86c8480d4684
Publikováno v:
Journal of the World Federation of Orthodontists.
Publikováno v:
Cell Stress
Ceramides are central intermediates of sphingolipid metabolism that can activate a variety of tumor suppressive cellular programs, including cell cycle arrest, senescence and apoptosis. Indeed, perturbations in ceramide generation and turnover are fr
Autor:
Dina G Hassan, Dagmar Müller, Patrick Niekamp, Siewert J. Marrink, Shashank Dadsena, Guilherme Razzera, Markus Schneider, Sergei Korneev, Manuel N. Melo, Joost C. M. Holthuis, John G. Mina, Helene Jahn, Svenja Bockelmann, Fikadu G. Tafesse
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Nature Communications, 10(1):1832. Nature Publishing Group
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Nature Communications, 10(1):1832. Nature Publishing Group
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Ceramides draw wide attention as tumor suppressor lipids that act directly on mitochondria to trigger apoptotic cell death. However, molecular details of the underlying mechanism are largely unknown. Using a photoactivatable ceramide probe, we here i