Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Dina Coertzen"'
Autor:
Jerome P. L. Ng, Yu Han, Li Jun Yang, Lyn-Marie Birkholtz, Dina Coertzen, Ho Ning Wong, Richard K. Haynes, Paolo Coghi, Vincent Kam Wai Wong
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Artemisinin, isolated from the traditional Chinese medicinal plant qīng hāo 青蒿 (Artemisia annua) and its derivatives are used for treatment of malaria. With treatment failures now being recorded for the derivatives and companion drugs used in a
Externí odkaz:
https://doaj.org/article/b5bdae38dcd7468283dd4e8dfca5fc88
Autor:
Ho Ning Wong, Vivian Padín-Irizarry, Mariëtte E. van der Watt, Janette Reader, Wilna Liebenberg, Lubbe Wiesner, Peter Smith, Korina Eribez, Elizabeth A. Winzeler, Dennis E. Kyle, Lyn-Marie Birkholtz, Dina Coertzen, Richard K. Haynes
Publikováno v:
Frontiers in Chemistry, Vol 7 (2020)
We have demonstrated previously that amino-artemisinins including artemiside and artemisone in which an amino group replaces the oxygen-bearing substituents attached to C-10 of the current clinical artemisinin derivatives dihydroartemisinin (DHA), ar
Externí odkaz:
https://doaj.org/article/9ff757caa9884186a32c1431718e41e5
Autor:
Liezl Gibhard, Dina Coertzen, Janette Reader, Mariëtte E. van der Watt, Lyn-Marie Birkholtz, Ho Ning Wong, Kevin T. Batty, Richard K. Haynes, Lubbe Wiesner
Publikováno v:
Pharmaceutics, Vol 13, Iss 12, p 2066 (2021)
Because of the need to replace the current clinical artemisinins in artemisinin combination therapies, we are evaluating fitness of amino-artemisinins for this purpose. These include the thiomorpholine derivative artemiside obtained in one scalable s
Externí odkaz:
https://doaj.org/article/961b961512034a18beeab2e2a9be0ff9
Autor:
Xolani Henry Makhoba, Adélle Burger, Dina Coertzen, Tawanda Zininga, Lyn-Marie Birkholtz, Addmore Shonhai
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0152626 (2016)
S-adenosylmethionine decarboxylase (PfAdoMetDC) from Plasmodium falciparum is a prospective antimalarial drug target. The production of recombinant PfAdoMetDC for biochemical validation as a drug target is important. The production of PfAdoMetDC in E
Externí odkaz:
https://doaj.org/article/5bc12027781646d2a84f6399a5ff3a36
Autor:
Marianna Stampolaki, Satish R. Malwal, Nadine Alvarez-Cabrera, Zijun Gao, Mohammad Moniruzzaman, Svitlana O. Babii, Nikolaos Naziris, André Rey-Cibati, Mariana Valladares-Delgado, Andreea L. Turcu, Kyung-Hwa Baek, Trong-Nhat Phan, Hyeryon Lee, Mattheo Alcaraz, Savannah Watson, Mariette van der Watt, Dina Coertzen, Natasa Efstathiou, Maria Chountoulesi, Carolyn M. Shoen, Ioannis P. Papanastasiou, Jose Brea, Michael H. Cynamon, Lyn-Marié Birkholtz, Laurent Kremer, Joo Hwan No, Santiago Vázquez, Gustavo Benaim, Costas Demetzos, Helen I. Zgurskaya, Thomas Dick, Eric Oldfield, Antonios D. Kolocouris
Publikováno v:
ACS Infectious Diseases. 9:342-364
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d90461f4e36371da98af3c8fcd49163a
https://doi.org/10.1021/acsinfecdis.2c00537
https://doi.org/10.1021/acsinfecdis.2c00537
Autor:
Dickson Mambwe, Constance M. Korkor, Amanda Mabhula, Zama Ngqumba, Cleavon Cloete, Malkeet Kumar, Paula Ladeia Barros, Meta Leshabane, Dina Coertzen, Dale Taylor, Liezl Gibhard, Mathew Njoroge, Nina Lawrence, Janette Reader, Diogo Rodrigo Moreira, Lyn-Marie Birkholtz, Sergio Wittlin, Timothy J. Egan, Kelly Chibale
Publikováno v:
Journal of Medicinal Chemistry. 65:16695-16715
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be13f3671115eb74fe7def09b01a1d32
https://doi.org/10.1021/acs.jmedchem.2c01516
https://doi.org/10.1021/acs.jmedchem.2c01516
Autor:
Janette Reader, Kelly Chibale, Mariëtte van der Watt, Lyn-Marie Birkholtz, Henrico Langeveld, Peter Mubanga Cheuka, Godwin Akpeko Dziwornu, Dina Coertzen, Meta Leshabane
Publikováno v:
Transactions of the Royal Society of South Africa. 76:225-233
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3e62252a9c125413adfd2f5da4f361c
https://doi.org/10.1080/0035919x.2021.1982792
https://doi.org/10.1080/0035919x.2021.1982792
Autor:
Marianna Stampolaki, Satish Malwal, Nadine Alvarez, Zijun Gao, Mohammad Moniruzzaman, Svitlana Babii, Nikolaos Naziris, André Rey-Cibati, Mariana Valladares-Delgado, Andreea Turcu, Kyung-Hwa Baek, Hyeryon Lee, Matthéo Alcaraz, Savannah Watson, Mariëtte van der Watt, Dina Coertzen, Natasa Efstathiou, Ioannis Stylianakis, Maria Chountoulesi, Carolyn Schoen, Ioannis Papanastasiou, José Brea, Michael Cynamon, Lyn-Marie Birkholtz, Laurent Kremer, Joo Hwan No, Santiago Vazquez, Gustavo Benaim, Costas Demetzos, Helen Zgurskaya, Thomas Dick, Eric Oldfield, Antonios Kolocouris
SQ109 is a tuberculosis drug candidate that has high potency against Mycobacterium tuberculosis and is thought to function at least in part by blocking cell wall biosynthesis by inhibiting the MmpL3 transporter. It also has activity against bacteria
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9134204720e18151a5bb4fe61122aae7
https://doi.org/10.26434/chemrxiv-2022-xm94p
https://doi.org/10.26434/chemrxiv-2022-xm94p
Autor:
Lauren B. Arendse, James M. Murithi, Tarrick Qahash, Charisse Flerida A. Pasaje, Luiz C. Godoy, Sumanta Dey, Liezl Gibhard, Sonja Ghidelli-Disse, Gerard Drewes, Marcus Bantscheff, Maria J. Lafuente-Monasterio, Stephen Fienberg, Lynn Wambua, Samuel Gachuhi, Dina Coertzen, Mariëtte van der Watt, Janette Reader, Ayesha S. Aswat, Erica Erlank, Nelius Venter, Nimisha Mittal, Madeline R. Luth, Sabine Ottilie, Elizabeth A. Winzeler, Lizette L. Koekemoer, Lyn-Marie Birkholtz, Jacquin C. Niles, Manuel Llinás, David A. Fidock, Kelly Chibale
Publikováno v:
Science Translational Medicine. 14
Compounds acting on multiple targets are critical to combating antimalarial drug resistance. Here, we report that the human “mammalian target of rapamycin” (mTOR) inhibitor sapanisertib has potent prophylactic liver stage activity, in vitro and i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::983eea505ec8dd3d5aabe3b1a5634b48
https://doi.org/10.1126/scitranslmed.abo7219
https://doi.org/10.1126/scitranslmed.abo7219
Autor:
Lyn-Marie Birkholtz, Dickson Mambwe, Dina Coertzen, Janette Reader, Dale Taylor, Malkeet Kumar, Mariëtte van der Watt, Kelly Chibale, Richard Ferger, Mathew Njoroge
Publikováno v:
ACS Med Chem Lett
[Image: see text] In the context of drug repositioning and expanding the existing structure–activity relationship around astemizole (AST), a new series of analogues were designed, synthesized, and evaluated for their antiplasmodium activity. Among
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3581afed6bad3935eddba74e720c7b3f
https://doi.org/10.1021/acsmedchemlett.1c00328
https://doi.org/10.1021/acsmedchemlett.1c00328