Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Dina Aweida"'
Autor:
Yara Eid Mutlak, Dina Aweida, Alexandra Volodin, Bar Ayalon, Nitsan Dahan, Anna Parnis, Shenhav Cohen
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Insulin receptor signaling governs central physiological functions related to cell growth and metabolism. Here the authors use protein complex purification and super-resolution microscopy to show that insulin receptor activity requires association wi
Externí odkaz:
https://doaj.org/article/6c9dbe296ba64797a1152b1bf96ac0cf
Autor:
Andriy S. Yatsenko, Mariya M. Kucherenko, Yuanbin Xie, Dina Aweida, Henning Urlaub, Renate J. Scheibe, Shenhav Cohen, Halyna R. Shcherbata
Publikováno v:
BMC Medicine, Vol 18, Iss 1, Pp 1-26 (2020)
Abstract Background Dystroglycanopathies are a group of inherited disorders characterized by vast clinical and genetic heterogeneity and caused by abnormal functioning of the ECM receptor dystroglycan (Dg). Remarkably, among many cases of diagnosed d
Externí odkaz:
https://doaj.org/article/49832caf1b204e2eb9ef64383bcaa850
Autor:
Ruth Shiloh, Yuval Gilad, Yaara Ber, Miriam Eisenstein, Dina Aweida, Shani Bialik, Shenhav Cohen, Adi Kimchi
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
DAPK2 is a calmodulin-regulated protein kinase implicated in autophagy regulation, but how physiological stress leads to its activation is yet unknown. Here, the authors show that the central metabolic sensor AMPK phosphorylates DAPK2 to promote auto
Externí odkaz:
https://doaj.org/article/551c55a627344344abff89cae54e5c69
Autor:
Dina Aweida, Shenhav Cohen
Publikováno v:
Biomolecules, Vol 11, Iss 1, p 110 (2021)
Protein degradation maintains cellular integrity by regulating virtually all biological processes, whereas impaired proteolysis perturbs protein quality control, and often leads to human disease. Two major proteolytic systems are responsible for prot
Externí odkaz:
https://doaj.org/article/8fce7de60b884a80947d4b580dedfc22
The AAA-ATPase ATAD1 and its partners promote degradation of desmin intermediate filaments in muscle
Autor:
Shenhav Cohen, Dina Aweida
Maintenance of desmin intermediate filaments (IF) is vital for muscle plasticity and function, and their perturbed integrity due to accelerated loss or aggregation causes atrophy and myopathies. Calpain-1-mediated disassembly of ubiquitinated desmin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::805a5232503c8bb64e85ccb2c27d3da8
https://doi.org/10.1101/2022.01.24.477493
https://doi.org/10.1101/2022.01.24.477493
Autor:
Mariya M. Kucherenko, Shenhav Cohen, Yuanbin Xie, Henning Urlaub, Dina Aweida, Halyna R. Shcherbata, Andriy S. Yatsenko, Renate J. Scheibe
Publikováno v:
BMC Medicine
BMC Medicine, Vol 18, Iss 1, Pp 1-26 (2020)
BMC Medicine, Vol 18, Iss 1, Pp 1-26 (2020)
Background Dystroglycanopathies are a group of inherited disorders characterized by vast clinical and genetic heterogeneity and caused by abnormal functioning of the ECM receptor dystroglycan (Dg). Remarkably, among many cases of diagnosed dystroglyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f11cac0b75364258e8b53ea6f5c110fb
http://resolver.sub.uni-goettingen.de/purl?gs-1/17143
http://resolver.sub.uni-goettingen.de/purl?gs-1/17143
Publikováno v:
The Journal of Cell Biology
Phosphorylation by protein kinase GSK3-β is essential for desmin filament depolymerization by calpain-1 and the resulting myofibril destruction in muscle atrophy.
Myofibril breakdown is a fundamental cause of muscle wasting and inevitable seque
Myofibril breakdown is a fundamental cause of muscle wasting and inevitable seque
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c237f1d37f1299e29f6f89835f22b48
https://doi.org/10.1083/jcb.201802018
https://doi.org/10.1083/jcb.201802018
Autor:
Yuval Gilad, Shani Bialik, Yaara Ber, Shenhav Cohen, Adi Kimchi, Miriam Eisenstein, Dina Aweida, Ruth Shiloh
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Nature Communications
Nature Communications
Autophagy is an intracellular degradation process essential for adaptation to metabolic stress. DAPK2 is a calmodulin-regulated protein kinase, which has been implicated in autophagy regulation, though the mechanism is unclear. Here, we show that the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d06670be48f363671e41d925f1fcff5f
https://doaj.org/article/551c55a627344344abff89cae54e5c69
https://doaj.org/article/551c55a627344344abff89cae54e5c69
Autor:
Bar Ayalon, Nitsan Dahan, Alexandra Volodin, Dina Aweida, Shenhav Cohen, Yara Eid Mutlak, Anna Parnis
Signaling through the insulin receptor governs central physiological functions related to cell growth and metabolism. Here we show by tandem native protein complex purification approach and super-resolution STED microscopy that insulin receptor activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc3b4e2255224a3583da4e591b4c503d
https://doi.org/10.1101/517789
https://doi.org/10.1101/517789