Výsledky vyhledávání - "Dina A Faddah"

Akademický článek

Single-cell multiomic profiling of human lungs reveals cell-type-specific and age-dynamic control of SARS-CoV2 host genes

Publikováno v: eLife, Vol 9 (2020)

Respiratory failure associated with COVID-19 has placed focus on the lungs. Here, we present single-nucleus accessible chromatin profiles of 90,980 nuclei and matched single-nucleus transcriptomes of 46,500 nuclei in non-diseased lungs from donors of

Externí odkaz: https://doaj.org/article/a3ede76a7aec424cbe10045fed11ea98

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Akademický článek

Systematic identification of balanced transposition polymorphisms in Saccharomyces cerevisiae.

Autor: Dina A Faddah, Eric W Ganko, Caroline McCoach, Joseph K Pickrell, Sean E Hanlon, Frederick G Mann, Joanna O Mieczkowska, Corbin D Jones, Jason D Lieb, Todd J Vision

Publikováno v: PLoS Genetics, Vol 5, Iss 6, p e1000502 (2009)

High-throughput techniques for detecting DNA polymorphisms generally do not identify changes in which the genomic position of a sequence, but not its copy number, varies among individuals. To explore such balanced structural polymorphisms, we used ar

Externí odkaz: https://doaj.org/article/7883736c185f4c3f9945529f3c23b193

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Single-Cell Analysis Reveals that Expression of Nanog Is Biallelic and Equally Variable as that of Other Pluripotency Factors in Mouse ESCs

Autor: Haoyi Wang, Dina A. Faddah, Rudolf Jaenisch, Yarden Katz, Yosef Buganim, Albert W. Cheng

Publikováno v: PMC

The homeodomain transcription factor Nanog is a central part of the core pluripotency transcriptional network and plays a critical role in embryonic stem cell (ESC) self-renewal. Several reports have suggested that Nanog expression is allelically reg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb1d4d73642b3cee4df98b104753e9bd
https://doi.org/10.1016/j.stem.2013.04.019

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Single-Cell Expression Analyses during Cellular Reprogramming Reveal an Early Stochastic and a Late Hierarchic Phase

Autor: Sandy Klemm, Kibibi Ganz, Yosef Buganim, Elena Itskovich, Alexander van Oudenaarden, Styliani Markoulaki, Dina A. Faddah, Albert W. Cheng, Rudolf Jaenisch

Publikováno v: Cell, 150(6), 1209-1222. Elsevier B.V.

SummaryDuring cellular reprogramming, only a small fraction of cells become induced pluripotent stem cells (iPSCs). Previous analyses of gene expression during reprogramming were based on populations of cells, impeding single-cell level identificatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a443e92808264d7b781dd3f8b9b6c67
https://doi.org/10.1016/j.cell.2012.08.023

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A farnesyltransferase inhibitor prevents both the onset and late progression of cardiovascular disease in a progeria mouse model

Autor: Urraca Tavarez, Hong San, Karen N. Conneely, Michelle Olive, Michael R. Erdos, Brian C. Capell, Elizabeth G. Nabel, Francis S. Collins, Renu Virmani, Xiaoyan Chen, Santhi K. Ganesh, Kan Cao, Frank D. Kolodgie, Dina A. Faddah, Xuan Qu, Hedwig Avallone

Publikováno v: Proceedings of the National Academy of Sciences. 105:15902-15907

Hutchinson-Gilford progeria syndrome (HGPS) is the most dramatic form of human premature aging. Death occurs at a mean age of 13 years, usually from heart attack or stroke. Almost all cases of HGPS are caused by a de novo point mutation in the lamin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eff2edbf962a7fcaac4004641138fe9
https://doi.org/10.1073/pnas.0807840105

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Progressive vascular smooth muscle cell defects in a mouse model of Hutchinson–Gilford progeria syndrome

Autor: Renu Virmani, Thomas N. Wight, Leslie B. Gordon, Stacie Perkins, Jun Cheng, Francis S. Collins, Frank D. Kolodgie, Michelle Olive, Michael R. Erdos, Maria Eriksson, Hong San, Xuan Qu, Elizabeth G. Nabel, Santhi K. Ganesh, Hedwig Avallone, Dina A. Faddah, Ingrid A. Harten, Renee Varga, Brian C. Capell

Publikováno v: Proceedings of the National Academy of Sciences. 103:3250-3255

Children with Hutchinson–Gilford progeria syndrome (HGPS) suffer from dramatic acceleration of some symptoms associated with normal aging, most notably cardiovascular disease that eventually leads to death from myocardial infarction and/or stroke u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfdc50f7cffcfc723d5e621b767d222b
https://doi.org/10.1073/pnas.0600012103

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Systematic Identification of Culture Conditions for Induction and Maintenance of Naive Human Pluripotency

Publikováno v: Cell Stem Cell

Summary Embryonic stem cells (ESCs) of mice and humans have distinct molecular and biological characteristics, raising the question of whether an earlier, “naive” state of pluripotency may exist in humans. Here we took a systematic approach to id

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ebd7a6d6a0a2f30a24153e6cd400e78

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Transcriptional profiling of cells sorted by RNA abundance

Autor: Alexander van Oudenaarden, Dina A. Faddah, Kay Wiebrands, Rudolf Jaenisch, Sandy Klemm, Dylan Mooijman, Stefan Semrau

Publikováno v: Nature Methods, 11(5), 549-51. Nature Publishing Group

We have developed a quantitative technique for sorting cells on the basis of endogenous RNA abundance, with a molecular resolution of 10-20 transcripts. We demonstrate efficient and unbiased RNA extraction from transcriptionally sorted cells and repo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9905c6b1ffec714489512d8101240c5b
https://pure.knaw.nl/portal/en/publications/59fa3ea2-0d2b-4cb6-83de-76257c808a01

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