Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Dina Montufar‐Solis"'
Autor:
Jack J. W. A. van Loon, Olga P. Berezovska, Theodorus J. M. Bervoets, Dina Montufar-Solis, Cor M. Semeins, Behrouz Zandieh-Doulabi, P. Natalia V. Rodionova, Jackie Duke, J. Paul Veldhuijzen
Publikováno v:
npj Microgravity, Vol 10, Iss 1, Pp 1-9 (2024)
Abstract In a previous Space Shuttle/Spacelab experiment (STS-42), we observed direct responses of isolated fetal mouse long bones to near weightlessness. This paper aimed to verify those results and study the effects of daily 1×g exposure during mi
Externí odkaz:
https://doaj.org/article/26401e664c4f47e89d84a5e313f4ac14
Autor:
Junchen Liu, Ransome van der Hoeven, Walaa E. Kattan, Jeffrey T. Chang, Dina Montufar-Solis, Wei Chen, Maurice Wong, Yong Zhou, Carlito B. Lebrilla, John F. Hancock
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
KRAS is a small GTPase that regulates cell proliferation. Here, the authors show that a subset of cell surface glycosphingolipids regulate KRAS plasma membrane localization by modulating inner leaflet lipid composition, uncovering a requirement for K
Externí odkaz:
https://doaj.org/article/7c042b78ee0049b58df0d81f70b376de
Autor:
Dina Montufar-Solis, John R Klein
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0146111 (2016)
The thyroid stimulating hormone beta-subunit (TSHβ) with TSHα form a glycoprotein hormone that is produced by the anterior pituitary in the hypothalamus-pituitary-thyroid (HPT) axis. Although TSHβ has been known for many years to be made by cells
Externí odkaz:
https://doaj.org/article/53004bfd382f4e0381f168d432746d2b
Autor:
Walaa E. Kattan, Junchen Liu, Dina Montufar-Solis, Hong Liang, Bhargavi Brahmendra Barathi, Ransome van der Hoeven, Yong Zhou, John F. Hancock
Publikováno v:
Proc Natl Acad Sci U S A
KRAS is mutated in 90% of human pancreatic ductal adenocarcinomas (PDACs). To function, KRAS must localize to the plasma membrane (PM) via a C-terminal membrane anchor that specifically engages phosphatidylserine (PtdSer). This anchor-binding specifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc2bc90be68f3b0e3ad8311cb61de91c
https://doi.org/10.1073/pnas.2114126118
https://doi.org/10.1073/pnas.2114126118
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e56436 (2013)
Roquin, an E3 ubiquitin ligase that localizes to cytosolic RNA granules, is involved in regulating mRNA stability and translation. Mice that have a M199R mutation in the Roquin protein (referred to as sanroque or Roquin(san/san) mice) develop autoimm
Externí odkaz:
https://doaj.org/article/accfff4cd7704b65bc4cee5a443a83c1
Autor:
Sabita Thapa, Zhiqing Liu, John F. Hancock, Xiaoping Ma, Jeffrey A. Frost, Dharini van der Hoeven, Jia Zhou, Haiying Chen, Wei Chen, Na Ye, Dina Montufar-Solis, Ransome van der Hoeven, Kwang-Jin Cho, Pingyuan Wang, Kristen M. Rehl
Publikováno v:
European journal of medicinal chemistry. 217
KRAS plays an essential role in regulating cell proliferation, differentiation, migration and survival. Mutated KRAS is a major driver of malignant transformation in multiple human cancers. We showed previously that fendiline (6) is an effective inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2bbddff96219f66fbe271bb58a6bdaf
https://pubmed.ncbi.nlm.nih.gov/33756124
https://pubmed.ncbi.nlm.nih.gov/33756124
Autor:
Dina Montufar-Solis, Xiaoping Ma, Wei Chen, Yan Zuo, Ransome van der Hoeven, Dharini van der Hoeven, Kwang-Jin Cho, Sarah E. Kovar, Kandice R. Levental, John F. Hancock, Jeffrey A. Frost, Ali Naji, Yong Zhou
Publikováno v:
Molecular and cellular biology. 38(3)
K-Ras must localize to the plasma membrane (PM) for biological activity. We show here that multiple acid sphingomyelinase (ASM) inhibitors, including tricyclic antidepressants, mislocalized phosphatidylserine (PtdSer) and K-RasG12V from the PM, resul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::365a965a9d4a93ad19bbb0e7fded4a7c
https://pubmed.ncbi.nlm.nih.gov/29158292
https://pubmed.ncbi.nlm.nih.gov/29158292
Publikováno v:
Biochem Biophys Res Commun
Roquin is an E3 ligase that regulates mRNA stability. Mice with a mutation in the Rc3h1 gene and Roquin protein, referred to as Roquin(san/san) or sanroque mice, develop broad-spectrum chronic inflammatory conditions and autoimmune pathologies. Our l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::340af2b42e378d342c77da20f78435a3
https://europepmc.org/articles/PMC8019515/
https://europepmc.org/articles/PMC8019515/
Publikováno v:
International Journal of Experimental Pathology. 91:276-280
Soluble gp130 (sgp130) has been shown to suppress the inflammatory response of autoimmune pathologies; however, its effects on virus infection are not known. Here, we report that intraperitoneal treatment of mice with sgp130-Fc fusion protein at the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::40b7c28c29349937cac16fa9e85a8e53
https://doi.org/10.1111/j.1365-2613.2010.00710.x
https://doi.org/10.1111/j.1365-2613.2010.00710.x
Autor:
Daniel D. Carson, Jacqueline T. Hecht, Dina Montufar-Solis, Mark B. Snuggs, Allison Scott, Tiffany Sanford, P. Jackie Duke, Deborah Hogue, William G. Cole, Mark A. Bernard, W. Barry Van Winkle
Publikováno v:
Journal of Bone and Mineral Research. 15:442-450
The EXT genes are a group of putative tumor suppressor genes that previously have been shown to participate in the development of hereditary multiple exostoses (HME), HME-associated and isolated chondrosarcomas. Two HME disease genes, EXT1 and EXT2,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::681f6db02e7dc425357f740c8f31ba70
https://doi.org/10.1359/jbmr.2000.15.3.442
https://doi.org/10.1359/jbmr.2000.15.3.442