Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Dina, De Sousa"'
Autor:
Walter Maetzler, Leonor Correia Guedes, Kirsten Nele Emmert, Jennifer Kudelka, Hanna Luise Hildesheim, Emma Paulides, Hayley Connolly, Kristen Davies, Valentina Dilda, Teemu Ahmaniemi, Luisa Avedano, Raquel Bouça-Machado, Michael Chambers, Meenakshi Chatterjee, Peter Gallagher, Johanna Graeber, Corina Maetzler, Hanna Kaduszkiewicz, Norelee Kennedy, Victoria Macrae, Laura Carrasco Marín, Anusha Moses, Alessandro Padovani, Andrea Pilotto, Natasha Ratcliffe, Ralf Reilmann, Madalena Rosario, Stefan Schreiber, Dina De Sousa, Geert Van Gassen, Lori Ann Warring, Klaus Seppi, C. Janneke van der Woude, Joaquim J. Ferreira, Wan-Fai Ng
Publikováno v:
Digital Biomarkers, Vol 8, Iss 1, Pp 30-39 (2024)
Background: Fatigue is a prominent symptom in many diseases and is strongly associated with impaired daily function. The measurement of daily function is currently almost always done with questionnaires, which are subjective and imprecise. With the r
Externí odkaz:
https://doaj.org/article/660828ad7ec546d1a6dc10a64e7a913d
Autor:
Martha V. Koerner, Kashyap Chhatbar, Shaun Webb, Justyna Cholewa-Waclaw, Jim Selfridge, Dina De Sousa, Bill Skarnes, Barry Rosen, Mark Thomas, Joanna Bottomley, Ramiro Ramirez-Solis, Christopher Lelliott, David J. Adams, Adrian Bird
Publikováno v:
Epigenomes, Vol 3, Iss 1, p 7 (2019)
Most human genes are associated with promoters embedded in non-methylated, G + C-rich CpG islands (CGIs). Not all CGIs are found at annotated promoters, however, raising the possibility that many serve as promoters for transcripts that do not code fo
Externí odkaz:
https://doaj.org/article/36c594723aaf41e0a98ad45949e822cf
Autor:
Zaynab Umakhanova, Paul A. De Sousa, Michaela Winkelmann, Rob Haselberg, Astri Arnesen, Marina Tretyakova, Danuta Lis, Beatrice De Schepper, Vladimír Václavík, Hans Gommans, Filipa Júlio, Emilie Hermant, Marios Papantoniou, Svein Olaf Olsen, Josè Perez Casanova, Cristina Ferreira, Ferdinando Squitieri, Ruth Blanco, Barbara D’Alessio, Sabrina Maffi, Dina De Sousa
Publikováno v:
F: Clinical studies: case reports, observational studies and trials.
Background The development of effective therapies for Huntington’s disease (HD) requires an active, informed, and lasting commitment from HD families to research. Specifically, those traditionally less involved in studies should be heard and engage
Autor:
Filipa Júlio, Ruth Blanco, Josè Perez Casanova, Barbara D’Alessio, Beatrice De Schepper, Dina De Sousa, Paul De Sousa, Cristina Ferreira, Hans Gommans, Rob Haselberg, Emilie Hermant, Danuta Lis, Sabrina Maffi, Svein Olaf Olsen, Marios Papantoniou, Ferdinando Squitieri, Marina Tretyakova, Zaynab Umakhanova, Vladimír Václavík, Michaela Winkelmann, Astri Arnesen, on behalf of the European Huntington Association
Publikováno v:
Journal of Personalized Medicine, Vol 11, Iss 815, p 815 (2021)
Journal of Personalized Medicine
Volume 11
Issue 8
Journal of Personalized Medicine
Volume 11
Issue 8
There has been great progress in Huntington’s disease (HD) research. Yet, effective treatments to halt disease before the onset of disabling symptoms are still unavailable. Scientific breakthroughs require an active and lasting commitment from fami
Publikováno v:
PLoS ONE, Vol 5, Iss 4, p e9937 (2010)
Differentiation of embryonic stem (ES) cells is accompanied by silencing of the Oct-4 gene and de novo DNA methylation of its regulatory region. Previous studies have focused on the requirements for promoter region methylation. We therefore undertook
Externí odkaz:
https://doaj.org/article/953033e4ec004449b1692e08e8a028a1
Autor:
Rebekah Tillotson, Dina De Sousa, Martha V. Koerner, Jacky Guy, Matthew J. Lyst, Mitchell A. Lazar, Jim Selfridge, Laura FitzPatrick, Alastair R.W. Kerr, Zheng Sun, Adrian Bird
Publikováno v:
Koerner, M V, Fitzpatrick, L, Selfridge, J, Guy, J, De Sousa, D, Tillotson, R, Kerr, A, Sun, Z, Lazar, M A, Lyst, M J & Bird, A 2018, ' Toxicity of overexpressed MeCP2 is independent of HDAC3 activity ', Genes & Development, vol. 32, no. 23-24, pp. 1514-1524 . https://doi.org/10.1101/gad.320325.118
Duplication of the X-linked MECP2 gene causes a severe neurological syndrome whose molecular basis is poorly understood. To determine the contribution of known functional domains to overexpression toxicity, we engineered a mouse model that expresses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f9e9a5b5c6aff5436cc29cf6104de48
https://www.pure.ed.ac.uk/ws/files/80488137/Toxicity_of_overexpressed_PUB_OA_CC_BY_Genes_Dev._2018_Koerner_1514_24.pdf
https://www.pure.ed.ac.uk/ws/files/80488137/Toxicity_of_overexpressed_PUB_OA_CC_BY_Genes_Dev._2018_Koerner_1514_24.pdf
Autor:
Santos, Dina de Sousa e1 (AUTHOR) dina.santos@fareham.ac.uk
Publikováno v:
Mobilities. Nov2009, Vol. 4 Issue 3, p407-426. 20p.
Publikováno v:
Human Molecular Genetics. 21:3806-3814
Rett Syndrome is a neurological disorder caused by mutations in the X-linked MECP2 gene. Mouse models where Mecp2 is inactivated or mutated recapitulate several features of the disorder and have demonstrated a requirement for the protein to ensure br
Autor:
Dina de Sousa e Santos
Publikováno v:
Mobilities. 4:407-426
This paper discusses mobility and migration, focusing mainly on the cases of Afro‐Cuban jineteras who seek relationships with Europeans. Healthy (educated) hookers or decadent women? While Cuban government officials condemn the actions of Cuban jin
Publikováno v:
Suzuki, M M, Kerr, A R W, De Sousa, D & Bird, A 2007, ' CpG methylation is targeted to transcription units in an invertebrate genome ', Genome Research, vol. 17, no. 5, pp. 625-631 . https://doi.org/10.1101/gr.6163007
DNA is methylated at the dinucleotide CpG in genomes of a wide range of plants and animals. Among animals, variable patterns of genomic CpG methylation have been described, ranging from undetectable levels (e.g., in Caenorhabditis elegans) to high le