Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Din-Chi Chiu"'
Autor:
Hongyan Sun, Adnan Shami Shah, Din-Chi Chiu, Alessandro Bonfini, Nicolas Buchon, Jeremy M. Baskin
Publikováno v:
iScience, Vol 27, Iss 6, Pp 110113- (2024)
Summary: The gut epithelium is subject to constant renewal, a process reliant upon intestinal stem cell (ISC) proliferation that is driven by Wnt/β-catenin signaling. Despite the importance of Wnt signaling within ISCs, the relevance of Wnt signalin
Externí odkaz:
https://doaj.org/article/6951fd67c3bd40f6ad3a1771009e6aa1
Autor:
Din-Chi Chiu, Jeremy M. Baskin
Publikováno v:
Accounts of Chemical Research. 55:3088-3098
ConspectusMembranes are multifunctional supramolecular assemblies that encapsulate our cells and the organelles within them. Glycerophospholipids are the most abundant component of membranes. They make up the majority of the lipid bilayer and play bo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7b3defa1b705efd9b9a0ccbe9fb5cd2
https://doi.org/10.1021/acs.accounts.2c00510
https://doi.org/10.1021/acs.accounts.2c00510
Autor:
Keng-Chang Tsai, Yih-Shyun E. Cheng, Jim-Min Fang, Ting-Jen Cheng, Jia-Tsrong Jan, Peng-Hao Hsu, Kuan-Lin Wu, Din-Chi Chiu, Pei-Shan Lee
Publikováno v:
European Journal of Medicinal Chemistry. 154:314-323
Zanamivir (ZA) and guanidino-oseltamivir carboxylic acid (GOC) are very potent inhibitors against influenza neuraminidase (NA). The guanidinium moiety plays an important role in NA binding; however, its polar cationic nature also hinders the use of Z
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31d34b949b18166e79ce837ea141333e
https://doi.org/10.1016/j.ejmech.2018.05.030
https://doi.org/10.1016/j.ejmech.2018.05.030
Autor:
Ting-Ting Li, Wen-I Huang, Keng-Chang Tsai, Din-Chi Chiu, Yin-Chen Tseng, Jia-Tsrong Jan, Peng-Cheng Wang, Ting-Jen Cheng, Jim-Min Fang
Publikováno v:
European Journal of Medicinal Chemistry. 145:224-234
Peramivir is an efficacious neuraminidase (NA) inhibitor for treatment of influenza by intravenous administration. However, the efficacy of peramivir toward the H275Y mutant is appreciably reduced. To address this drawback, conjugation of peramivir w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30bd60e97a9905875a6b439e13657b73
https://doi.org/10.1016/j.ejmech.2017.12.072
https://doi.org/10.1016/j.ejmech.2017.12.072
Publikováno v:
Organic & Biomolecular Chemistry. 15:9910-9922
Peramivir is an effective anti-influenza drug in the clinical treatment of influenza, but its efficacy toward the H275Y mutant is reduced. The previously reported cocrystal structures of inhibitors in the mutant neuraminidase (NA) suggest that the hy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b0ea2a4f2c030eb24ecf1cc4872d559
https://doi.org/10.1039/c7ob02374j
https://doi.org/10.1039/c7ob02374j