Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Dimple Harit"'
Autor:
Alison Schaefer, Bing Yang, Holly A. Schroeder, Dimple Harit, Mike S. Humphry, Larry Zeitlin, Kevin J. Whaley, Jacques Ravel, William A. Fischer, Samuel K. Lai
Publikováno v:
Emerging Microbes and Infections, Vol 13, Iss 1 (2024)
ABSTRACTVaginal transmission from semen of male Ebola virus (EBOV) survivors has been implicated as a potential origin of Ebola virus disease (EVD) outbreaks. While EBOV in semen must traverse cervicovaginal mucus (CVM) to reach target cells, the beh
Externí odkaz:
https://doaj.org/article/0b91368b024b4ae7a579ea704274de58
Publikováno v:
mBio, Vol 11, Iss 1 (2020)
ABSTRACT Despite their exceptional potencies, the broad tropism of most commonly used lentivirus (LV) vectors limits their use for targeted gene delivery in vivo. We hypothesized that we could improve the specificity of LV targeting by coupling (i) r
Externí odkaz:
https://doaj.org/article/ec5128a80ad04306b61419331c297045
Autor:
Kenetta L. Nunn, Ying-Ying Wang, Dimple Harit, Michael S. Humphrys, Bing Ma, Richard Cone, Jacques Ravel, Samuel K. Lai
Publikováno v:
mBio, Vol 6, Iss 5 (2015)
ABSTRACT Cervicovaginal mucus (CVM) can provide a barrier that precludes HIV and other sexually transmitted virions from reaching target cells in the vaginal epithelium, thereby preventing or reducing infections. However, the barrier properties of CV
Externí odkaz:
https://doaj.org/article/f06f90e916ed4739aa583d2db6aa6288
Autor:
Alex Chen, Scott A McKinley, Feng Shi, Simi Wang, Peter J Mucha, Dimple Harit, M Gregory Forest, Samuel K Lai
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0131351 (2015)
Secretory immunoglobulin A (sIgA), a dimeric antibody found in high quantities in the gastrointestinal mucosa, is broadly associated with mucosal immune protection. A distinguishing feature of sIgA is its ability to crosslink pathogens, thereby creat
Externí odkaz:
https://doaj.org/article/c9d34f21d91c46c8aa31f53f7da85e53
Publikováno v:
mBio, Vol 11, Iss 1 (2020)
mBio, Vol 11, Iss 1, p e02990-19 (2020)
mBio
mBio, Vol 11, Iss 1, p e02990-19 (2020)
mBio
The goal of gene therapy is specific delivery and expression of therapeutic genes to target cells and tissues. Common lentivirus (LV) vectors are efficient gene delivery vehicles but offer little specificity. Here, we report an effective and versatil
Autor:
Dimple Harit, Scott A. McKinley, Alison Schaefer, Samuel K. Lai, Ying Ying Wang, William A. Fischer, Phoebe T. Lee, Justin D. McCallen, Kevin J. Whaley, Bing Yang, Jay M. Newby, Priya A. Kumar, Harendra Arora, Larry Zeitlin
Publikováno v:
The Journal of infectious diseases. 218(6)
Filoviruses, including Ebola, have the potential to be transmitted via virus-laden droplets deposited onto mucus membranes. Protecting against such emerging pathogens will require understanding how they may transmit at mucosal surfaces and developing
Autor:
Bing Ma, Samuel K. Lai, Richard A. Cone, Michael S. Humphrys, Ying Ying Wang, Jacques Ravel, Dimple Harit, Kenetta L. Nunn
Publikováno v:
mBio, Vol 6, Iss 5 (2015)
Cervicovaginal mucus (CVM) can provide a barrier that precludes HIV and other sexually transmitted virions from reaching target cells in the vaginal epithelium, thereby preventing or reducing infections. However, the barrier properties of CVM differ
Publikováno v:
Journal of controlled release : official journal of the Controlled Release Society. 220
Tracking the dynamic motion of individual nanoparticles or viruses offers quantitative insights into their real-time behavior and fate in different biological environments. Indeed, particle tracking is a powerful tool that has facilitated the develop
Autor:
Samuel K. Lai, Priya A. Kumar, Harendra Arora, Ying Ying Wang, Durai B. Subramani, Dimple Harit
Publikováno v:
European Respiratory Journal. 49:1601709
Airway mucus is thought to serve as a dynamic filter that can trap respiratory viruses in the dense mucin network [1], and quickly eliminate them along with airway mucus from the respiratory tract. Nevertheless, viruses must penetrate airway mucus to
Autor:
Scott A. McKinley, Dimple Harit, Peter J. Mucha, M. Gregory Forest, Feng Shi, Samuel K. Lai, Simi Wang, Alex Chen
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0131351 (2015)
PLoS ONE
PLoS ONE
Secretory immunoglobulin A (sIgA), a dimeric antibody found in high quantities in the gastrointestinal mucosa, is broadly associated with mucosal immune protection. A distinguishing feature of sIgA is its ability to crosslink pathogens, thereby creat