Zobrazeno 1 - 10
of 174
pro vyhledávání: '"Dimo, Dietrich"'
Autor:
Friederike Hoffmann, Alina Franzen, Luka de Vos, Lennert Wuest, Zsófi Kulcsár, Simon Fietz, Alexander Philippe Maas, Sarah Hollick, Marie Yatou Diop, Jennis Gabrielpillai, Timo Vogt, Pia Kuster, Romina Zarbl, Joern Dietrich, Glen Kristiansen, Peter Brossart, Jennifer Landsberg, Sebastian Strieth, Dimo Dietrich
Publikováno v:
Clinical Epigenetics, Vol 15, Iss 1, Pp 1-13 (2023)
Abstract Background The majority of patients with recurrent or metastasized head and neck squamous cell carcinoma (HNSCC) do not benefit from immune checkpoint blockade (ICB) while several patients experience severe and persistent immune-mediated sid
Externí odkaz:
https://doaj.org/article/2828807dfb384e6996689ecfb93a477e
Autor:
Damian J. Ralser, Emmanuelle Herr, Luka de Vos, Zsófi Kulcsár, Romina Zarbl, Niklas Klümper, Gerrit H. Gielen, Alexander Philippe Maas, Friederike Hoffmann, Jörn Dietrich, Pia Kuster, Alexander Mustea, Nicole Glodde, Glen Kristiansen, Sebastian Strieth, Jennifer Landsberg, Dimo Dietrich
Publikováno v:
Biomarker Research, Vol 11, Iss 1, Pp 1-17 (2023)
Abstract Background Inducible T cell costimulator ICOS is an emerging target in immuno-oncology. The aim of this study was to investigate the epigenetic regulation of ICOS in melanoma by DNA methylation. Methods We comprehensively investigate ICOS DN
Externí odkaz:
https://doaj.org/article/e3bb36e51ff44e6f9b8d700fc99a8755
Autor:
Niklas Klümper, Lennert Wüst, Jonas Saal, Damian J. Ralser, Romina Zarbl, Jonas Jarczyk, Johannes Breyer, Danijel Sikic, Bernd Wullich, Christian Bolenz, Florian Roghmann, Michael Hölzel, Manuel Ritter, Sebastian Strieth, Arndt Hartmann, Philipp Erben, Ralph M. Wirtz, Jennifer Landsberg, Dimo Dietrich, Markus Eckstein
Publikováno v:
OncoImmunology, Vol 12, Iss 1 (2023)
ABSTRACTPD-L1 status assessed by immunohistochemistry (IHC) has failed to reliably predict outcomes for patients with metastatic urothelial carcinoma (mUC) on immune checkpoint blockade (ICB). PD-L1 promoter methylation is an epigenetic mechanism tha
Externí odkaz:
https://doaj.org/article/db84a83835784401bcaeca4a8df3487d
Autor:
Luka de Vos, Ingela Grünwald, Emma Grace Bawden, Jörn Dietrich, Kathrin Scheckenbach, Constanze Wiek, Romina Zarbl, Friedrich Bootz, Jennifer Landsberg, Dimo Dietrich
Publikováno v:
Epigenetics, Vol 15, Iss 11, Pp 1195-1212 (2020)
CTLA-4 blocking therapeutic antibodies are currently under investigation in head and neck squamous cell carcinoma (HNSCC). A better understanding of the epigenetic regulation of the CD28 superfamily members CD28, CTLA-4, and ICOS and their B7 ligands
Externí odkaz:
https://doaj.org/article/57166499a8bc49da998576e00116f167
Autor:
Dimo Dietrich, Lutz Trojan, Niklas Klümper, Damian J Ralser, Romina Zarbl, Glen Kristiansen, Marieta Toma, Manuel Ritter, Michael Hölzel, Jörg Ellinger, Markus Eckstein, Danijel Sikic, Katrin Schlack, Andres Jan Schrader, Marc Rehlinghaus, Michèle J Hoffmann, Günter Niegisch, Annemarie Uhlig, Julie Steinestel, Konrad Steinestel, Ralph M Wirtz, Sebastian Strieth
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 8 (2021)
Externí odkaz:
https://doaj.org/article/6e349fc1c30b4c718dcf71148fb36faf
Autor:
Verena Sailer, Ulrike Sailer, Emma Grace Bawden, Romina Zarbl, Constanze Wiek, Timo J. Vogt, Joern Dietrich, Sophia Loick, Ingela Grünwald, Marieta Toma, Carsten Golletz, Andreas Gerstner, Glen Kristiansen, Friedrich Bootz, Kathrin Scheckenbach, Jennifer Landsberg, Dimo Dietrich
Publikováno v:
EBioMedicine, Vol 48, Iss , Pp 341-352 (2019)
Background: The immune checkpoint, indoleamine 2,3-dioxygenase 1, is under investigation as target of novel immunotherapies for cancers, including head and neck squamous cell carcinomas (HNSCC). The aim of our study was to analyze DNA methylation of
Externí odkaz:
https://doaj.org/article/19f13459f3a443e282ec3bbaa5759ff0
Autor:
Madeleine Sassenberg, Johanna Droop, Wolfgang A. Schulz, Dimo Dietrich, Sophia Marie Loick, Constanze Wiek, Kathrin Scheckenbach, Nadine T. Gaisa, Michèle J. Hoffmann
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-14 (2019)
Abstract Background Few diagnostic and prognostic biomarkers are available for head-and-neck squamous cell carcinoma (HNSCC). Long non-coding RNAs (lncRNAs) have shown promise as biomarkers in other cancer types and in some cases functionally contrib
Externí odkaz:
https://doaj.org/article/115d49ac3a2c49debea39eedcc596b40
Autor:
Friederike Hoffmann, Anne Fröhlich, Judith Sirokay, Luka de Vos, Romina Zarbl, Jörn Dietrich, Sebastian Strieth, Jennifer Landsberg, Dimo Dietrich
Publikováno v:
Melanoma Research. 33:116-125
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5400316b9cba2a590b78fbd019199d7c
https://doi.org/10.1097/cmr.0000000000000879
https://doi.org/10.1097/cmr.0000000000000879
Autor:
Anne Fröhlich, Judith Sirokay, Simon Fietz, Timo J. Vogt, Jörn Dietrich, Romina Zarbl, Mike Florin, Pia Kuster, Gonzalo Saavedra, Susana Ramírez Valladolid, Friederike Hoffmann, Lukas Flatz, Sandra S. Ring, Carsten Golletz, Torsten Pietsch, Sebastian Strieth, Peter Brossart, Gerrit H. Gielen, Glen Kristiansen, Friedrich Bootz, Jennifer Landsberg, Dimo Dietrich
Publikováno v:
EBioMedicine, Vol 59, Iss , Pp 102962- (2020)
Background: The co-receptor lymphocyte-activation gene-3 (LAG3, LAG-3, CD223) is a potential target for immune checkpoint inhibition immunotherapies. However, little is known about the biological and clinical significance of LAG3 DNA methylation in m
Externí odkaz:
https://doaj.org/article/e0df1f7dff7f4d3890cfd8c1b6d74e95
Autor:
Anne Fröhlich, Sophia Loick, Emma Grace Bawden, Simon Fietz, Jörn Dietrich, Eric Diekmann, Gonzalo Saavedra, Holger Fröhlich, Dennis Niebel, Judith Sirokay, Romina Zarbl, Gerrit H. Gielen, Glen Kristiansen, Friedrich Bootz, Jennifer Landsberg, Dimo Dietrich
Publikováno v:
EBioMedicine, Vol 52, Iss , Pp - (2020)
Background: Immunotherapy, including checkpoint inhibition, has remarkably improved prognosis in advanced melanoma. Despite this success, acquired resistance is still a major challenge. The T cell costimulatory receptor TNFRSF9 (also known as 4-1BB a
Externí odkaz:
https://doaj.org/article/6d94cbfe2baa48b3be285fced529a34c