A Large-Scale Genome-Wide Study of Gene-Sleep Duration Interactions for Blood Pressure in 811,405 Individuals from Diverse Populations.

Autor: Nagarajan P; Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Winkler TW; Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany., Bentley AR; Center for Research on Genomics and Global Health, National Human Genome Research Institute, US National Institutes of Health, Bethesda, MD, USA., Miller CL; Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesvil le, VA, USA.; Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville ,VA, USA., Kraja AT; University of Mississippi Medical Center, Jackson, MS, USA., Schwander K; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA., Lee S; Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, USA., Wang W; Department of Human Genetics, Leiden University Medical Center, Leiden, Netherlands., Brown MR; Human Genetics Center, Department of Epidemiology, University of Texas Health Science Center at Houston School of Public Health, Houston, TX, USA., Morrison JL; Division of Biostatistics, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, USA., Giri A; Division of Quantitative Sciences, Department of Obstetrics & Gynecology, Vanderbilt University Medical Center, Nashville, TN, USA.; Biomedical Laboratory Research and Development, Tennessee Valley Healthcare System (626), Department of Veterans Affairs/ Nashville, TN, USA., O'Connell JR; Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., Bartz TM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.; Department of Biostatistics, University of Washington, Seattle, WA, USA., de las Fuentes L; Cardiovascular Division, Department of Medicine, Washington University School of Medicine in St. Louis, MO, USA.; Center for Biostatistics and Data Science, Institute for Informatics, Data Science, and Biostatistics, Washington University in St. Louis, School of Medicine, St. Louis, MO, USA., Gudmundsdottir V; Icelandic Heart Association, Kopavogur, Iceland.; Faculty of Medicine, Department of Health Sciences, University of Iceland, Reykjavik, Iceland., Guo X; The Institute for Translational Genomics and Population Sciences, Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Harris SE; Department of Psychology, The University of Edinburgh, Edinburgh, UK., Huang Z; Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, US., Kals M; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia., Kho M; Graduate School of Data Science, Seoul National University, Seoul, South Korea., Lefevre C; Department of Data Sciences, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia., Luan J; MRC Epidemiology Unit, University of Cambridge, Cambridge, UK., Lyytikäinen LP; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.; Finnish Cardiovascular Research Center - Tampere, Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere, Finland., Mangino M; Department of Twin Research, King's College London, London, UK.; National Heart & Lung Institute, Cardiovascular Genomics and Precision Medicine, Imperial College London, London, UK., Milaneschi Y; Department of Psychiatry, Amsterdam UMC/Vrije universiteit, Amsterdam, Netherlands.; GGZ inGeest, Amsterdam, Netherlands., Palmer ND; Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, NC, USA., Rao V; Division of Nephrology, Department of Medicine, University of Illinois Chicago, Chicago, USA., Rauramaa R; Kuopio Research Institute of Exercise Medicine, Kuopio, Finland., Shen B; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, Maryland., Stadler S; Department of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany., Sun Q; Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Tang J; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Thériault S; Department of Molecular Biology, Medical Biochemistry and Pathology, Université Laval, Quebec City, Qc, Canada., van der Graaf A; Statistical Genetics Group, Department of Computational Biology, University of Lausanne, Lausanne, Switzerland., van der Most PJ; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands., Wang Y; Department of Epidemiology, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Weiss S; Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany., Westerman KE; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Clinical and Translational Epidemiology Unit, Mongan Institute, Massachusetts General Hospital, Boston, MA, USA., Yang Q; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Yasuharu T; Graduate School of Public Health, Shizuoka Graduate University of Public Health, Shizuoka, Japan.; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Zhao W; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Zhu W; Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Altschul D; Department of Psychology, The University of Edinburgh, Edinburgh, UK., Ansari MAY; Department of Data Science, University of Mississippi Medical Center, Jackson, MS, USA., Anugu P; Jackson Heart Study, University of Mississippi Medical Center, Jackson, MS, USA., Argoty-Pantoja AD; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands., Arzt M; Department of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany., Aschard H; Department of Computational Biology, F-75015 Paris, France Institut Pasteur, Université Paris Cité, Paris, France.; Department of Epidemiology, Harvard TH School of Public Health, Boston, MA, USA., Attia JR; School of Medicine and Public Health, College of Health Medicine and Wellbeing, University of Newcastle, New Lambton Heights, NSW, Australia., Bazzanno L; Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, US., Breyer MA; Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Brody JA; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Cade BE; Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Chen HH; Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Ida Chen YD; The Institute for Translational Genomics and Population Sciences, Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Chen Z; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands., de Vries PS; Human Genetics Center, Department of Epidemiology, University of Texas Health Science Center at Houston School of Public Health, Houston, TX, USA., Dimitrov LM; Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, NC, USA., Do A; Center for Biostatistics and Data Science, Institute for Informatics, Data Science, and Biostatistics, Washington University in St. Louis, School of Medicine, St. Louis, MO, USA., Du J; Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Dupont CT; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA., Edwards TL; Biomedical Laboratory Research and Development, Tennessee Valley Healthcare System (626), Department of Veterans Affairs/ Nashville, TN, USA.; Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, US A., Evans MK; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, Maryland., Faquih T; Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Felix SB; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.; Cardiology, Pneumology, Infectious Diseases, Intensive Care Medicine, Department of Internal Medicine B, Un iversity Medicine Greifswald, Greifswald, Germany., Fisher-Hoch SP; School of Public Health, The University of Texas Health Science Center at Houston (UTHealth), Brownsville, TX, USA., Floyd JS; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA., Graff M; Department of Epidemiology, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Gu C; Center for Biostatistics and Data Science, Institute for Informatics, Data Science, and Biostatistics, Washington University in St. Louis, School of Medicine, St. Louis, MO, USA., Gu D; Shenzhen Key Laboratory of Cardiovascular Health and Precision Medicine, Southern University of Science an d Technology, Shenzhen, China., Hairston KG; Department of Endocrinology, Wake Forest University School of Medicine, Winston-Salem, NC, USA., Hanley AJ; Department of Nutritional Sciences, University of Toronto, Toronto, ON, Canada., Heid IM; Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany., Heikkinen S; Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, Kuopio., Highland HM; Department of Epidemiology, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Hood MM; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Kähönen M; Finnish Cardiovascular Research Center - Tampere, Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere, Finland.; Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland., Karvonen-Gutierrez CA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Kawaguchi T; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Kazuya S; Graduate School of Public Health, Shizuoka Graduate University of Public Health, Shizuoka, Japan., Kelly TN; Division of Nephrology, Department of Medicine, University of Illinois Chicago, Chicago, USA., Komulainen P; Kuopio Research Institute of Exercise Medicine, Kuopio, Finland., Levy D; Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.; Framingham Heart Study, Framingham, MA, USA., Lin HJ; The Institute for Translational Genomics and Population Sciences, Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Liu PY; The Institute for Translational Genomics and Population Sciences, Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Marques-Vidal P; Department of Medicine, Internal Medicine, Lausanne University Hospital (CHUV), Lausanne, Switzerland.; Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland., McCormick JB; School of Public Health, The University of Texas Health Science Center at Houston (UTHealth), Brownsville, TX, USA., Mei H; Department of Data Science, University of Mississippi Medical Center, Jackson, MS, USA., Meigs JB; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA., Menni C; Department of Twin Research, King's College London, London, UK., Nam K; Graduate School of Data Science, Seoul National University, Seoul, South Korea., Nolte IM; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands., Pacheco NL; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, Maryland., Petty LE; Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Polikowsky HG; Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Province MA; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA., Psaty BM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA., Raffield LM; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA., Raitakari OT; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.; Research Centre of Applied and Preventive Cardiovascular Medicine, and Department of Clinical Physiology and Nuclear Medicine, University of Turku, and Turku University Hospital, Turku, Finland.; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland., Rich SS; Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.; Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA., Riha RL; Department of Sleep Medicine, The University of Edinburgh, Edinburgh, UK., Risch L; Faculty of Medical Sciences , Institute for Laboratory Medicine, Private University in the Principality of Liecht enstein, Vaduz, Liechtenstein.; Center of Laboratory Medicine, Institute of Clinical Chemistry, University of Bern and Inselspital, Bern, Switze rland., Risch M; Central Laboratory, Cantonal Hospital Graubünden, Chur, Switzerland.; Medical Laboratory, Dr. Risch Anstalt, Vaduz, Liechtenstein., Ruiz-Narvaez EA; Department of Nutritional Sciences, University of Michigan, Ann Arbor, MI, USA., Scott RJ; School of Biomedical Sciences and Pharmacy, College of Health Medicine and Wellbeing, University of Newcastle, New Lambton Heights, NSW, Australia., Sitlani CM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Smith JA; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Sofer T; Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; CardioVascular Institute (CVI), Beth Israel Deaconess Medical Center, Boston, MA, USA., Teder-Laving M; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia., Völker U; Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany., Vollenweider P; Department of Medicine, Internal Medicine, Lausanne University Hospital (CHUV), Lausanne, Switzerland.; Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland., Wang G; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA., van Dijk KW; Department of Human Genetics, Leiden University Medical Center, Leiden, Netherlands.; Department of Internal Medicine, Division of Endocrinology, Leiden, Netherlands., Wilson OD; Biomedical Laboratory Research and Development, Tennessee Valley Healthcare System (626), Department of Veterans Affairs/ Nashville, TN, USA.; Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Xia R; Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, USA., Yao J; The Institute for Translational Genomics and Population Sciences, Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Young KL; Department of Epidemiology, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Zhang R; Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, US., Zhu X; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, Ohio, USA., Below JE; Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Böger CA; Department of Nephrology, University Hospital Regensburg, Regensburg, Germany.; Department of Nephrology and Rheumatology, Kliniken Südostbayern, Traunstein, Germany.; KfH Kidney Centre Traunstein, Traunstein, Germany., Conen D; Population Health Research Institute, Medicine, McMaster University, Hamilton, On, Canada., Cox SR; Department of Psychology, The University of Edinburgh, Edinburgh, UK., Dörr M; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.; Cardiology, Pneumology, Infectious Diseases, Intensive Care Medicine, Department of Internal Medicine B, Un iversity Medicine Greifswald, Greifswald, Germany., Feitosa MF; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA., Fox ER; Jackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA., Franceschini N; Department of Epidemiology, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Gharib SA; Pulmonary, Critical Care and Sleep Medicine, Medicine, University of Washington, Seattle, WA, USA., Gudnason V; Icelandic Heart Association, Kopavogur, Iceland.; Faculty of Medicine, Department of Health Sciences, University of Iceland, Reykjavik, Iceland., Harlow SD; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., He J; Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, US.; Tulane University Translational Sciences Institute, New Orleans, LA , USA., Holliday EG; School of Medicine and Public Health, College of Health Medicine and Wellbeing, University of Newcastle, New Lambton Heights, NSW, Australia., Kutalik Z; Statistical Genetics Group, Department of Computational Biology, University of Lausanne, Lausanne, Switzerland.; Center for Primary Care and Public Health, University of Lausanne, Lausanne, Switzerland., Lakka TA; Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, Kuopio.; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland.; Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland., Lawlor DA; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Lee S; Graduate School of Data Science, Seoul National University, Seoul, South Korea., Lehtimäki T; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.; Finnish Cardiovascular Research Center - Tampere, Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere, Finland., Li C; Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, US., Liu CT; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Mägi R; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia., Matsuda F; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Morrison AC; Human Genetics Center, Department of Epidemiology, University of Texas Health Science Center at Houston School of Public Health, Houston, TX, USA., Penninx BW; Department of Psychiatry, Amsterdam UMC/Vrije universiteit, Amsterdam, Netherlands.; GGZ inGeest, Amsterdam, Netherlands., Peyser PA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Rotter JI; The Institute for Translational Genomics and Population Sciences, Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Snieder H; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands., Spector TD; Department of Twin Research, King's College London, London, UK., Wagenknecht LE; Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, USA., Wareham NJ; MRC Epidemiology Unit, University of Cambridge, Cambridge, UK., Zonderman AB; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, Maryland., North KE; Department of Epidemiology, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Fornage M; Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, USA.; Human Genetics Center, Department of Epidemiology, University of Texas Health Science Center at Houston School of Public Health, Houston, TX, USA., Hung AM; Biomedical Laboratory Research and Development, Tennessee Valley Healthcare System (626), Department of Veterans Affairs/ Nashville, TN, USA.; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, Ohio, USA., Manning AK; Clinical and Translational Epidemiology Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Metabolism Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Gauderman J; Division of Biostatistics, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, USA., Chen H; Human Genetics Center, Department of Epidemiology, University of Texas Health Science Center at Houston School of Public Health, Houston, TX, USA.; Center for Precision Health, McWilliams School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX, USA., Munroe PB; Clinical Pharmacology and Precision Medicine, Queen Mary University of London, London, UK., Rao DC; Center for Biostatistics and Data Science, Institute for Informatics, Data Science, and Biostatistics, Washington University in St. Louis, School of Medicine, St. Louis, MO, USA., van Heemst D; Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Lei den, Netherlands., Redline S; Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Noordam R; Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Lei den, Netherlands., Wang H; Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.

Publikováno v: MedRxiv : the preprint server for health sciences [medRxiv] 2024 Mar 08. Date of Electronic Publication: 2024 Mar 08.

Multiethnic Genome-Wide Association Study of Diabetic Retinopathy Using Liability Threshold Modeling of Duration of Diabetes and Glycemic Control.

Autor: Pollack S; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA., Igo RP Jr; Department of Population and Quantitative Health Sciences, Case Western University, Cleveland, OH., Jensen RA; Cardiovascular Health Research Unit, Department of Medicine, Epidemiology and Health Services, University of Washington, Seattle, WA., Christiansen M; Cardiovascular Health Research Unit, Department of Medicine, Epidemiology and Health Services, University of Washington, Seattle, WA., Li X; Institute for Translational Genomics and Population Sciences, LA BioMed and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA., Cheng CY; Duke-NUS Medical School, Singapore.; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore., Ng MCY; Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, NC.; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC., Smith AV; Department of Medicine, University of Iceland, Reykjavík, Iceland., Rossin EJ; Massachusetts Eye and Ear Department of Ophthalmology, Harvard Medical School, Boston, MA., Segrè AV; Massachusetts Eye and Ear Department of Ophthalmology, Harvard Medical School, Boston, MA., Davoudi S; Massachusetts Eye and Ear Department of Ophthalmology, Harvard Medical School, Boston, MA., Tan GS; Duke-NUS Medical School, Singapore.; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore., Chen YI; Institute for Translational Genomics and Population Sciences, LA BioMed and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA., Kuo JZ; Institute for Translational Genomics and Population Sciences, LA BioMed and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA.; Medical Affairs, Ophthalmology, Sun Pharmaceutical Industries, Inc., Princeton, NJ., Dimitrov LM; Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, NC.; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC., Stanwyck LK; Massachusetts Eye and Ear Department of Ophthalmology, Harvard Medical School, Boston, MA., Meng W; Division of Population Health Sciences, Ninewells Hospital and Medical School, University of Dundee School of Medicine, Scotland, U.K., Hosseini SM; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada., Imamura M; Laboratory for Endocrinology, Metabolism and Kidney Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Department of Advanced Genomic and Laboratory Medicine, Graduate School of Medicine, University of the Ryukyus, Nishihara, Japan.; Division of Clinical Laboratory and Blood Transfusion, University of the Ryukyus Hospital, Nishihara, Japan., Nousome D; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA., Kim J; Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX., Hai Y; Institute for Translational Genomics and Population Sciences, LA BioMed and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA., Jia Y; Institute for Translational Genomics and Population Sciences, LA BioMed and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA., Ahn J; Department of Ophthalmology, SMG-SNU Boramae Medical Center, Seoul National University College of Medicine, Seoul, Korea., Leong A; Endocrine Unit and Diabetes Unit, Division of General Internal Medicine, Massachusetts General Hospital, Boston, MA., Shah K; Section of Genetic Medicine, University of Chicago, Chicago, IL., Park KH; Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea., Guo X; Institute for Translational Genomics and Population Sciences, LA BioMed and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA., Ipp E; Section of Diabetes and Metabolism, Harbor-UCLA Medical Center, University of California, Los Angeles, Los Angeles, CA., Taylor KD; Institute for Translational Genomics and Population Sciences, LA BioMed and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA., Adler SG; Department of Nephrology and Hypertension, Los Angeles Biomedical Research Institute at Harbor-University of California, Torrance, CA., Sedor JR; Department of Medicine, Case Western Reserve University, Cleveland, OH.; Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH.; Division of Nephrology, MetroHealth System, Cleveland, OH., Freedman BI; Section on Nephrology, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC., Lee IT; Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.; School of Medicine, Chung Shan Medical University, Taichung, Taiwan.; School of Medicine, National Yang-Ming University, Taipei, Taiwan., Sheu WH; Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.; School of Medicine, Chung Shan Medical University, Taichung, Taiwan.; School of Medicine, National Yang-Ming University, Taipei, Taiwan.; School of Medicine, National Defense Medical Center, Taipei, Taiwan., Kubo M; RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Takahashi A; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan.; Department of Genomic Medicine, Research Institute, National Cerebral and Cardiovascular Center, Osaka, Japan., Hadjadj S; CHU de Poitiers, Centre d'Investigation Clinique, Poitiers, France.; Université de Poitiers, UFR Médecine Pharmacie, Centre d'Investigation Clinique 1402, Poitiers, France.; INSERM, Centre d'Investigation Clinique 1402, Poitiers, France.; L'Institut du Thorax, INSERM, CNRS, CHU Nantes, Nantes, France., Marre M; Université Paris Diderot, Sorbonne Paris Cité, Paris, France.; Department of Diabetology, Endocrinology and Nutrition, Assistance Publique-Hôpitaux de Paris, Bichat Hospital, DHU FIRE, Paris, France.; INSERM U1138, Centre de Recherche des Cordeliers, Paris, France., Tregouet DA; Team Genomics & Pathophysiology of Cardiovascular Diseases, UPMC, Sorbonne Universités, INSERM, UMR_S 1166, Paris, France.; Institute of Cardiometabolism and Nutrition, Paris, France., Mckean-Cowdin R; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA.; Department of Ophthalmology, USC Roski Eye Institute, Keck School of Medicine of the University of Southern California, Los Angeles, CA., Varma R; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA.; Department of Ophthalmology, USC Roski Eye Institute, Keck School of Medicine of the University of Southern California, Los Angeles, CA., McCarthy MI; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, U.K.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, U.K.; NIHR Oxford Biomedical Research Centre, Churchill Hospital, Oxford, U.K., Groop L; Department of Clinical Sciences, Faculty of Medicine, Lund University, Malmö, Sweden., Ahlqvist E; Department of Clinical Sciences, Faculty of Medicine, Lund University, Malmö, Sweden., Lyssenko V; Department of Clinical Sciences, Faculty of Medicine, Lund University, Malmö, Sweden.; Department of Clinical Science, KG Jebsen Center for Diabetes Research, University of Bergen, Bergen, Norway., Agardh E; Department of Clinical Sciences, Faculty of Medicine, Lund University, Malmö, Sweden., Morris A; Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, U.K., Doney ASF; Molecular and Clinical Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, U.K., Colhoun HM; Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh, Edinburgh, U.K., Toppila I; Folkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.; Abdominal Center, Nephrology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland., Sandholm N; Folkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.; Abdominal Center, Nephrology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland., Groop PH; Folkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.; Abdominal Center, Nephrology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland.; Department of Diabetes, Central Clinical School, Monash University, Melbourne, Victoria, Australia., Maeda S; Laboratory for Endocrinology, Metabolism and Kidney Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Department of Advanced Genomic and Laboratory Medicine, Graduate School of Medicine, University of the Ryukyus, Nishihara, Japan.; Division of Clinical Laboratory and Blood Transfusion, University of the Ryukyus Hospital, Nishihara, Japan., Hanis CL; Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX., Penman A; Department of Preventive Medicine, John D. Bower School of Population Health, University of Mississippi Medical Center, Jackson, MS., Chen CJ; Department of Ophthalmology, University of Mississippi Medical Center, Jackson, MS., Hancock H; Department of Ophthalmology, University of Mississippi Medical Center, Jackson, MS., Mitchell P; Centre for Vision Research, Westmead Institute for Medical Research, The University of Sydney, Sydney, New South Wales, Australia., Craig JE; Department of Ophthalmology, Flinders University, Bedford Park, South Australia, Australia., Chew EY; Division of Epidemiology and Clinical Applications, National Eye Institute, National Institutes of Health, Bethesda, MD., Paterson AD; Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada.; Program in Genetics & Genome Biology, Hospital for Sick Children, Toronto, Ontario, Canada.; Epidemiology and Biostatistics, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada., Grassi MA; Grassi Retina, Naperville, IL.; Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL., Palmer C; Pat MacPherson Centre for Pharmacogenetics and Pharmacogenomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, U.K., Bowden DW; Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, NC.; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC., Yaspan BL; Genentech, Inc., South San Francisco, CA., Siscovick D; Institute for Urban Health, New York Academy of Medicine, New York, NY., Cotch MF; Division of Epidemiology and Clinical Applications, National Eye Institute, National Institutes of Health, Bethesda, MD., Wang JJ; Duke-NUS Medical School, Singapore.; Centre for Vision Research, Westmead Institute for Medical Research, The University of Sydney, Sydney, New South Wales, Australia., Burdon KP; Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia., Wong TY; Duke-NUS Medical School, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Klein BEK; Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI., Klein R; Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI., Rotter JI; Institute for Translational Genomics and Population Sciences, LA BioMed and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA., Iyengar SK; Department of Population and Quantitative Health Sciences, Case Western University, Cleveland, OH., Price AL; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA., Sobrin L; Massachusetts Eye and Ear Department of Ophthalmology, Harvard Medical School, Boston, MA lucia_sobrin@meei.harvard.edu.

Publikováno v: Diabetes [Diabetes] 2019 Feb; Vol. 68 (2), pp. 441-456. Date of Electronic Publication: 2018 Nov 28.

A genome-wide linkage and association analysis of imputed insertions and deletions with cardiometabolic phenotypes in Mexican Americans: The Insulin Resistance Atherosclerosis Family Study.

Autor: Gao C; Molecular Genetics and Genomics Program, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America.; Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America.; Center for Public Health Genomics, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America., Hsu FC; Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America., Dimitrov LM; Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America., Okut H; Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America., Chen YI; Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, United States of America.; Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, United States of America., Taylor KD; Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, United States of America.; Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, United States of America., Rotter JI; Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, United States of America.; Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, United States of America., Langefeld CD; Center for Public Health Genomics, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America.; Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America., Bowden DW; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America.; Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America., Palmer ND; Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America.; Center for Public Health Genomics, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America.; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America.; Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America.

Publikováno v: Genetic epidemiology [Genet Epidemiol] 2017 May; Vol. 41 (4), pp. 353-362. Date of Electronic Publication: 2017 Apr 05.