Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Dimitris Korovesis"'
Oxidative Stress in Age-Related Neurodegenerative Diseases: An Overview of Recent Tools and Findings
Publikováno v:
Antioxidants, Vol 12, Iss 1, p 131 (2023)
Reactive oxygen species (ROS) have been described to induce a broad range of redox-dependent signaling reactions in physiological conditions. Nevertheless, an excessive accumulation of ROS leads to oxidative stress, which was traditionally considered
Externí odkaz:
https://doaj.org/article/34f77faab4e347708924d61b8dbded49
Photoaffinity labeling followed by tandem mass spectrometry is an often used strategy to identify protein targets of small molecule drugs or drug candidates, which -- under ideal conditions -- enables the identification of the actual drug binding sit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef65527513179b214ba706ae3cc16ca9
https://doi.org/10.26434/chemrxiv-2023-fvrjl
https://doi.org/10.26434/chemrxiv-2023-fvrjl
Autor:
Jian Yang, Dimitris Korovesis, Shanping Ji, Jan Pascal Kahler, Roeland Vanhoutte, Steven H. L. Verhelst
Publikováno v:
Israel Journal of Chemistry. 63
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6195b85acb13c7a9add41082a36d094
https://doi.org/10.1002/ijch.202200094
https://doi.org/10.1002/ijch.202200094
Publikováno v:
ACS Chemical Biology. 15:3106-3111
Inositol-requiring enzyme 1α (IRE1α) is one of three endoplasmic reticulum stress sensors. Upon activation of its kinase domain, IRE1α splices the mRNA substrate XBP1, which activates the unfolded protein response. IRE1α has emerged as a therapeu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55afe163bdb72b4d19cc9761fd91d285
https://doi.org/10.1021/acschembio.0c00802
https://doi.org/10.1021/acschembio.0c00802
Autor:
Sofie Van Eygen, Rita Derua, Dimitris Korovesis, Thomas Sauter, Monica Vara-Perez, Leonidas G. Alexopoulos, Lasse Sinkkonen, Francesca Finotello, Nicole Rufo, Jan Rožanc, Michael Dewaele, Patrizia Agostinis, Abhishek D. Garg, Sophie Janssens, Peter de Witte, Steven H. L. Verhelst
Publikováno v:
Cell Death and Differentiation
CELL DEATH AND DIFFERENTIATION
CELL DEATH AND DIFFERENTIATION
Mounting evidence indicates that immunogenic therapies engaging the unfolded protein response (UPR) following endoplasmic reticulum (ER) stress favor proficient cancer cell-immune interactions, by stimulating the release of immunomodulatory/proinflam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e250130d194566c9e02cd034ace4c3c5
https://lirias.kuleuven.be/handle/123456789/679916
https://lirias.kuleuven.be/handle/123456789/679916
Protein kinases, one of the largest enzyme superfamilies, regulate many physiological and pathological processes. They are drug targets for multiple human diseases, including various cancer types. Probes for the photoaffinity labelling of kinases are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bb142472c6adcd27d53dec5ddd1f7e8
https://lirias.kuleuven.be/handle/123456789/671252
https://lirias.kuleuven.be/handle/123456789/671252
Publikováno v:
Molecular omics. 17(2)
Covalent chemical probes are important tools in chemical biology. They range from post-translational modification (PTM)-derived metabolic probes, to activity-based probes and photoaffinity labels. Identification of the probe targets is often performe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e572bfd865c7b29cdec5a9f51d1e6b9d
https://pubmed.ncbi.nlm.nih.gov/33507200
https://pubmed.ncbi.nlm.nih.gov/33507200
Autor:
Patrizia Agostinis, Thomas Sauter, Nicole Rufo, Lasse Sinkkonen, Francesca Finotello, Michael Dewaele, Sophie Janssens, Abhishek D. Garg, Jan Rozanc, Monica Vara Perez, Peter de Witte, Rita Derua, Dimitris Korovesis, Leonidas G. Alexopoulos, Sofie Van Eygen, Steven H. L. Verhelst
Cellular stress evoked by immunogenic anticancer treatments engaging the unfolded protein response (UPR) can elicit inflammation with conflicting therapeutic outcomes. To define cell-autonomous mechanisms coupling the UPR to molecular mediators of in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eef3a3a7fc376d3f543c617d87f5a2ff
https://doi.org/10.1101/2020.12.24.424330
https://doi.org/10.1101/2020.12.24.424330