Zobrazeno 1 - 10
of 148
pro vyhledávání: '"Dimitris Anastassiou"'
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 7, p e1009228 (2021)
During the last ten years, many research results have been referring to a particular type of cancer-associated fibroblasts associated with poor prognosis, invasiveness, metastasis and resistance to therapy in multiple cancer types, characterized by a
Externí odkaz:
https://doaj.org/article/5c5566e401cb4860abc940ba5c8ea226
Publikováno v:
PLoS ONE, Vol 14, Iss 1, p e0211213 (2019)
Tumors are heterogeneous in the sense that they consist of multiple subpopulations of cells, referred to as subclones, each of which is characterized by a distinct profile of genomic variations such as somatic mutations. Inferring the underlying clon
Externí odkaz:
https://doaj.org/article/85201775e3704092af018e7acd2de579
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0167994 (2016)
Exploring linkage disequilibrium (LD) patterns among the single nucleotide polymorphism (SNP) sites can improve the accuracy and cost-effectiveness of genomic association studies, whereby representative (tag) SNPs are identified to sufficiently repre
Externí odkaz:
https://doaj.org/article/bad3cbb70f234cd1ae77515c4bf67a2d
Publikováno v:
Cancer Informatics, Vol 2012, Iss 11, Pp 61-75 (2012)
Externí odkaz:
https://doaj.org/article/156ecac0cdb84a11bc21dfba14ff23fa
Publikováno v:
EURASIP Journal on Advances in Signal Processing, Vol 2004, Iss 1, Pp 29-42 (2004)
We performed frequency-domain analysis in the genomes of various organisms using tricolor spectrograms, identifying several types of distinct visual patterns characterizing specific DNA regions. We relate patterns and their frequency characteristics
Externí odkaz:
https://doaj.org/article/3595daf56dc34ccc83fb6cf1bd567470
Publikováno v:
PLoS Computational Biology, Vol 9, Iss 2, p e1002920 (2013)
Mining gene expression profiles has proven valuable for identifying signatures serving as surrogates of cancer phenotypes. However, the similarities of such signatures across different cancer types have not been strong enough to conclude that they re
Externí odkaz:
https://doaj.org/article/f82e2c5716b641e0a03dc3b953f2efe2
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e34705 (2012)
A stage-associated gene expression signature of coordinately expressed genes, including the transcription factor Slug (SNAI2) and other epithelial-mesenchymal transition (EMT) markers has been found present in samples from publicly available gene exp
Externí odkaz:
https://doaj.org/article/db3a4d2d9ac04b7f96cfa7979fd0bfe5
Autor:
Vinay Varadan, Dimitris Anastassiou
Publikováno v:
PLoS Computational Biology, Vol 2, Iss 6, p e68 (2006)
Computational analysis of gene expression data from microarrays has been useful for medical diagnosis and prognosis. The ability to analyze such data at the level of biological modules, rather than individual genes, has been recognized as important f
Externí odkaz:
https://doaj.org/article/400ad2a402c94e94909b10e88dbf3514
Autor:
C. Anthony Blau, Nicole D. Urban, J. David Beatty, Dimitris Anastassiou, Tai-Hsien Ou Yang, Wei-Yi Cheng, Catherine M. Coy, Amanda N. Kortum, Jason D. Thorpe, Chris P. Miller
Janus kinase-2 (JAK2) supports breast cancer growth, and clinical trials testing JAK2 inhibitors are under way. In addition to the tumor epithelium, JAK2 is also expressed in other tissues including immune cells; whether the JAK2 mRNA levels in breas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e8cbd1edff5bcc6d122f666659709d8
https://doi.org/10.1158/2326-6066.c.6548077
https://doi.org/10.1158/2326-6066.c.6548077
Autor:
C. Anthony Blau, Nicole D. Urban, J. David Beatty, Dimitris Anastassiou, Tai-Hsien Ou Yang, Wei-Yi Cheng, Catherine M. Coy, Amanda N. Kortum, Jason D. Thorpe, Chris P. Miller
PDF file - 188K, Supplementary Figure S1. JAK2 mRNA quantification in primary breast tumors. Supplementary Figure S2. Evaluating JAK2 mRNA and protein levels in human breast cancer cell lines. Supplementary Figure S3. Validating the specificity of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b23c79f554dc186d00f792002a99c1d
https://doi.org/10.1158/2326-6066.22536226
https://doi.org/10.1158/2326-6066.22536226