Výsledky vyhledávání - "Dimitris, Athineos"

Akademický článek

Apoptotic stress-induced FGF signalling promotes non-cell autonomous resistance to cell death

Autor: Florian J. Bock, Egor Sedov, Elle Koren, Anna L. Koessinger, Catherine Cloix, Désirée Zerbst, Dimitris Athineos, Jayanthi Anand, Kirsteen J. Campbell, Karen Blyth, Yaron Fuchs, Stephen W. G. Tait

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)

Abstract Damaged or superfluous cells are typically eliminated by apoptosis. Although apoptosis is a cell-autonomous process, apoptotic cells communicate with their environment in different ways. Here we describe a mechanism whereby cells under apopt

Externí odkaz: https://doaj.org/article/415af44f66154f70b3f34ec84435ad64

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Akademický článek

Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)

Dietary serine and glycine starvation has emerged as a potential therapy for cancer. Here, the authors show that inhibition of PHGDH, which mediates the first step in the serine synthesis pathway, improves the therapeutic efficacy of serine depletion

Externí odkaz: https://doaj.org/article/4b3a136e97e9418588502ed7dece3071

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Akademický článek

Loss of RAF kinase inhibitor protein is involved in myelomonocytic differentiation and aggravates RAS-driven myeloid leukemogenesis

Publikováno v: Haematologica, Vol 105, Iss 2 (2020)

RAS-signaling mutations induce the myelomonocytic differentiation and proliferation of hematopoietic stem and progenitor cells. Moreover, they are important players in the development of myeloid neoplasias. RAF kinase inhibitor protein (RKIP) is a ne

Externí odkaz: https://doaj.org/article/8c224b13657644bab272a39a821900d5

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Akademický článek

Increased formate overflow is a hallmark of oxidative cancer

Autor: Johannes Meiser, Anne Schuster, Matthias Pietzke, Johan Vande Voorde, Dimitris Athineos, Kristell Oizel, Guillermo Burgos-Barragan, Niek Wit, Sandeep Dhayade, Jennifer P. Morton, Emmanuel Dornier, David Sumpton, Gillian M. Mackay, Karen Blyth, Ketan J. Patel, Simone P. Niclou, Alexei Vazquez

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)

Serine catabolism to formate supplies one-carbon units for biosynthesis. Here the authors show that formate production in murine cancers with high oxidative metabolism exceeds the biosynthetic demand and that high formate levels promotes invasion of

Externí odkaz: https://doaj.org/article/3791b6fce2b1446482c02c147ec6dfd2

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Sensitisation of cancer cells to radiotherapy by serine and glycine starvation

Autor: Mattia Falcone, Alejandro Huerta Uribe, Vasileios Papalazarou, Alice C. Newman, Dimitris Athineos, Katrina Stevenson, Charles-Etienne Gabriel Sauvé, Yajing Gao, Jin K. Kim, Michael Del Latto, Maria Kierstead, Chao Wu, J. Joshua Smith, Paul B. Romesser, Anthony J. Chalmers, Karen Blyth, Oliver D. K. Maddocks

Publikováno v: British Journal of Cancer. 127:1773-1786

Background Cellular metabolism is an integral component of cellular adaptation to stress, playing a pivotal role in the resistance of cancer cells to various treatment modalities, including radiotherapy. In response to radiotherapy, cancer cells enga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1385c6eef7b39544a8e10a2a4128d740
https://doi.org/10.1038/s41416-022-01965-6

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Akademický článek

Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)

Cutaneous squamous cell carcinomas is a growing problem but the driver genes causing this remain poorly defined. Here, the authors demonstrate that inactivating driver mutations in TGFBR1 and TGFBR2occur in vemurafenib-induced and sporadic cutaneous

Externí odkaz: https://doaj.org/article/007e4295faa9467ba2f947c4d342dc0a

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